Vijay S Chauhan

Vijay S Chauhan, MD, FRCPC

Ventricular tachyarrhythmias are an important mode of sudden death in patients with cardiomyopathy. Animal studies suggest that abnormal ventricular repolarization can lead to ventricular arrhythmias. In humans, the relevance of cardiac repolarization as a substrate for arrhythmogenesis is not well understood. Our laboratory is characterizing the spatiotemporal distribution of ventricular repolarization in patients with cardiomyopathy and defining the dynamic range of repolarization in response to physiologic stress that can trigger ventricular arrhythmias. The experiments involve body surface and intracardiac recordings of repolarization under varying physiological conditions. Using linear and nonlinear dynamics, several aspects of cardiac repolarization are quantified including spatiotemporal heterogeneity, restitution, memory and alternans. The knowledge gained from our experiments will provide better understanding of the pathogenesis of lethal ventricular arrhythmias in cardiomyopathic patients which may lead to the development of novel antiarrhythmic therapies.
HeartRhythm Case Rep. 2017 Jan;3(1):22-26
Porta-Sánchez A, Ha ACT, Nayyar S, Dalvi R, Chauhan VS
Pacing Clin Electrophysiol. 2017 Feb 03;:
Weissler-Snir A, Gollob MH, Chauhan V, Care M, Spears DA
Circ Arrhythm Electrophysiol. 2016 Nov;9(11):
Nayyar S, Nair K, Chauhan VS
Am J Cardiol. 2016 Jul 29;
Weissler-Snir A, Chan RH, Adler A, Care M, Chauhan V, Gollob MH, Ziv-Baran T, Fourey D, Hindieh W, Rakowski H, Spears DA
Comput Biol Med. 2016 Jul 8;77:1-8
Hasan MA, Chauhan VS, Krishnan S
Circ Arrhythm Electrophysiol. 2016 Apr;9(4)
Herman AR, Cheung C, Gerull B, Simpson CS, Birnie DH, Klein GJ, Champagne J, Healey JS, Gibbs K, Talajic M, Gardner M, Bennett MT, Steinberg C, Janzen M, Gollob MH, Angaran P, Yee R, Leather R, Chakrabarti S, Sanatani S, Chauhan VS, Krahn AD
Nat Commun. 2016;7:11303
Orr N, Arnaout R, Gula LJ, Spears DA, Leong-Sit P, Li Q, Tarhuni W, Reischauer S, Chauhan VS, Borkovich M, Uppal S, Adler A, Coughlin SR, Stainier DY, Gollob MH
Pacing Clin Electrophysiol. 2016 Mar 30;
Viswanathan K, Suszko AM, DAS M, Jackson N, Gollob M, Cameron D, Spears D, Woo A, Rakowski H, Khurana M, Chauhan VS
Indian Pacing Electrophysiol J. 2015 May-Jun;15(3):168-71
Roshan J, Gizurarson S, Das M, Chauhan VS
Circ Arrhythm Electrophysiol. 2016 Jan;9(1)
Herman AR, Cheung C, Gerull B, Simpson CS, Birnie DH, Klein GJ, Champagne J, Healey JS, Gibbs K, Talajic M, Gardner M, Bennett MT, Steinberg C, Janzen M, Gollob MH, Angaran P, Yee R, Leather R, Chakrabarti S, Sanatani S, Chauhan VS, Krahn AD

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Associate Professor, Department of Physiology, University of Toronto