Vijay S Chauhan, MD, FRCPC

Ventricular tachyarrhythmias are an important mode of sudden death in patients with cardiomyopathy. Animal studies suggest that abnormal ventricular repolarization can lead to ventricular arrhythmias. In humans, the relevance of cardiac repolarization as a substrate for arrhythmogenesis is not well understood. Our laboratory is characterizing the spatiotemporal distribution of ventricular repolarization in patients with cardiomyopathy and defining the dynamic range of repolarization in response to physiologic stress that can trigger ventricular arrhythmias. The experiments involve body surface and intracardiac recordings of repolarization under varying physiological conditions. Using linear and nonlinear dynamics, several aspects of cardiac repolarization are quantified including spatiotemporal heterogeneity, restitution, memory and alternans. The knowledge gained from our experiments will provide better understanding of the pathogenesis of lethal ventricular arrhythmias in cardiomyopathic patients which may lead to the development of novel antiarrhythmic therapies.
J Interv Card Electrophysiol. 2018 Oct 08;:
Burstein B, Barbosa RS, Samuel M, Kalfon E, Philippon F, Birnie D, Mangat I, Redfearn D, Sandhu R, Macle L, Sapp J, Verma A, Healey JS, Becker G, Chauhan V, Coutu B, Roux JF, Leong-Sit P, Andrade JG, Veenhuyzen GD, Joza J, Bernier M, Essebag V
J Electrocardiol. 2018 Jul - Aug;51(4):720-722
Sud M, Chauhan VS, Madan M
PLoS One. 2018;13(6):e0199637
Nayyar S, Suszko A, Porta-Sanchez A, Dalvi R, Chauhan VS
PLoS One. 2018;13(5):e0197273
Liu J, Bayer JD, Aschar-Sobbi R, Wauchop M, Spears D, Gollob M, Vigmond EJ, Tsushima R, Backx PH, Chauhan VS
JACC Clin Electrophysiol. 2017 Nov;3(11):1220-1228
Kochhäuser S, Verma A, Dalvi R, Suszko A, Alipour P, Sanders P, Champagne J, Macle L, Nair GM, Calkins H, Wilber DJ, Chauhan VS
JACC Clin Electrophysiol. 2017 Apr;3(4):374-381
Porta-Sánchez A, Spillane DR, Harris L, Xue J, Dorsey P, Care M, Chauhan V, Gollob MH, Spears DA
Circ Arrhythm Electrophysiol. 2017 Sep;10(9):
Haldar SK, Magtibay K, Porta-Sanchez A, Massé S, Mitsakakis N, Lai PFH, Azam MA, Asta J, Kusha M, Dorian P, Ha ACT, Chauhan V, Deno DC, Nanthakumar K
Curr Cardiol Rep. 2017 Aug 16;19(9):88
Care M, Chauhan V, Spears D
Circ Arrhythm Electrophysiol. 2017 Jul;10(7):
Das M, Suszko AM, Nayyar S, Viswanathan K, Spears DA, Tomlinson G, Pinter A, Crystal E, Dalvi R, Krishnan S, Chauhan VS
HeartRhythm Case Rep. 2017 Jan;3(1):22-26
Porta-Sánchez A, Ha ACT, Nayyar S, Dalvi R, Chauhan VS

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Associate Professor, Department of Physiology, University of Toronto