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I lead a translational genomics program with the goals of 1) linking cancer genome alterations to clinical outcome; 2) monitoring shifts in cancer and immune cell populations during treatment; and 3) enabling comprehensive genomics as a routine medical test. To achieve these goals, we profile tumours and blood using cell-free DNA, immune repertoire, single-cell and whole-genome sequencing. We also develop software to share these data around the world. Our work advances the knowledgebase and infrastructure necessary to deliver genomic medicine to cancer patients worldwide.



Cell-free DNA in Hereditary And High- Risk Malignancies (CHARM)2: Evaluating the Performance of a cfDNA Blood Test for Early Cancer Detection


Study Status: active

Institute: Princess Margaret Cancer Centre

Health Conditions: Cancer

Infographic summary describing how an experimental blood test could detect cancer early.

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For a list of Dr. Pugh's publications, please visit PubMed, Scopus, Europe PMC or ORCID.




    • Assistant Professor, Department of Medical Biophysics, University of Toronto
    • Lead, Clinical Genomics Program, Princess Margaret Cancer Centre