The Kislinger Laboratory is located at the Princess Margaret Cancer Research Tower of the Princess Margaret Cancer Centre, the largest oncology treatment and research facility in Canada. The major goal of our lab is to apply proteomics technologies to cancer and cardiovascular research. Our research interests include technology development, using the latest generation of mass spectrometry instrumentation, basic cell biology and translational cancer research.
N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression.
J Biol Chem. 1999 Oct 29;274(44):31740-9
Barbiturate induced benzophenanthridine alkaloid formation proceeds by gene transcript accumulation in the California poppy.
Biochem Biophys Res Commun. 1997 Dec 18;241(2):606-10
Senior Scientist, Princess Margaret Cancer Centre