Suzanne Trudel

Suzanne Trudel, MSc, MD

My area of research concerns new drug development for the treatment of mature B cell malignancies based on molecular targets. This encompasses drug discovery and pharmacological profiling of candidate compounds, pre-clinical studies to validate the target and determine potential therapeutic mechanisms of action, the establishment of appropriate animal models for drug testing, and the development of Phase I/II clinical trials.

Chromosomal translocations are present in approximately 50% of multiple myeloma patients and probably represent the first and defining genetic event that leads to the development of this disease. Characterization of these translocations has led to the identification of critical dysregulated oncogenes (FGFR3 and MMSET, c-maf and mafB, cyclin D1 and D3) that are potential molecular targets for anti-cancer agents.

We have recently validated FGFR3 as molecular therapeutic target in t(4;14) myeloma and have identified CHIR-258 as an active drug against FGFR3 expressing myeloma cells in pre-clinical studies. We are about to launch the first ever, clinical trial of FGFR3 inhibition in myeloma and are focusing our efforts on the development and implementation of relevant biological endpoints for this novel class of anti-tumor drug. Validation of additional molecular targets in myeloma such as MMSET and the maf and cyclin family of genes is also under development.
Clin Lymphoma Myeloma Leuk. 2017 Jul 04;:
van Beers EH, van Vliet MH, Kuiper R, de Best L, Anderson KC, Chari A, Jagannath S, Jakubowiak A, Kumar SK, Levy JB, Auclair D, Lonial S, Reece D, Richardson P, Siegel DS, Stewart AK, Trudel S, Vij R, Zimmerman TM, Fonseca R
J Cancer. 2017;8(8):1417-1424
Darmon I, Morisse MC, Coutte A, Blonski M, Rhun EL, Taillandier L, Roufai DB, Desenclos C, Trudel S, Faivre JC, Blanchard N, Chauffert B, Boone M
Nat Commun. 2017 May 11;8:15086
Kis O, Kaedbey R, Chow S, Danesh A, Dowar M, Li T, Li Z, Liu J, Mansour M, Masih-Khan E, Zhang T, Bratman SV, Oza AM, Kamel-Reid S, Trudel S, Pugh TJ
Cancer Med. 2016 Nov 18;:
Kotchetkov R, Masih-Khan E, Chu CM, Atenafu EG, Chen C, Kukreti V, Trudel S, Tiedemann R, Reece DE
Clin Cancer Res. 2016 Nov 17;:
Petrova PS, Viller NN, Wong M, Pang X, Lin GH, Dodge K, Chai V, Chen H, Lee V, House V, Vigo NT, Jin D, Mutukura T, Charbonneau M, Truong T, Viau S, Johnson LD, Linderoth E, Sievers EL, Maleki Vareki S, Figueredo R, Pampillo M, Koropatnick J, Trudel S,...
Clin Lymphoma Myeloma Leuk. 2016 Jul;16(7):387-94
Reece DE, Trieu Y, Masih-Khan E, Atenafu EG, Chen C, Prica A, Tiedemann R, Trudel S, Kukreti V
JCI Insight. 2016;1(3)
Yu C, Liu Y, Chan JT, Tong J, Li Z, Shi M, Davani D, Parsons M, Khan S, Zhan W, Kyu S, Grunebaum E, Campisi P, Propst EJ, Jaye DL, Trudel S, Moran MF, Ostrowski M, Herrin BR, Lee FE, Sanz I, Cooper MD, Ehrhardt GR
Chem Commun (Camb). 2016 Jan 21;
Korpany KV, Mottillo C, Bachelder J, Cross SN, Dong P, Trudel S, Friščić T, Blum AS

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Associate Professor, Department of Medical Biophysics, University of Toronto