Sonya MacParland

Sonya MacParland, PhD

The liver is a unique immunological organ and home to cells of the innate and adaptive immune system. Immune dysregulation in the liver is a contributing factor to many disease processes including viral hepatitis, autoimmune hepatitis, liver cancer and inflammatory liver damage leading to fibrosis.

Dr. MacParland's research program is focused on translating fundamental knowledge about the immune biology of the liver into clinical applications. Dr. MacParland and her research team will investigate how liver immune dysregulation drives liver diseases, including chronic viral infection and inflammatory liver fibrosis. They will also examine how the liver immune environment can be therapeutically manipulated using nanoparticles to slow or reverse ongoing damage.
Circ Res. 2017 Aug 04;121(4):354-367
Cheng HS, Besla R, Li A, Chen Z, Shikatani EA, Nazari-Jahantigh M, Hammoutène A, Nguyen MA, Geoffrion M, Cai L, Khyzha N, Li T, MacParland SA, Husain M, Cybulsky MI, Boulanger CM, Temel RE, Schober A, Rayner KJ, Robbins CS, Fish JE
ACS Nano. 2017 Mar 28;11(3):2428-2443
MacParland SA, Tsoi KM, Ouyang B, Ma XZ, Manuel J, Fawaz A, Ostrowski MA, Alman BA, Zilman A, Chan WC, McGilvray ID
Can J Gastroenterol Hepatol. 2016;2016:7603526
van Buuren N, Fradette L, Grebely J, King A, Krajden M, MacParland SA, Marshall A, Saeed S, Wilson J, Klein MB, Sagan SM
Nat Mater. 2016 Nov;15(11):1212-1221
Tsoi KM, MacParland SA, Ma XZ, Spetzler VN, Echeverri J, Ouyang B, Fadel SM, Sykes EA, Goldaracena N, Kaths JM, Conneely JB, Alman BA, Selzner M, Ostrowski MA, Adeyi OA, Zilman A, McGilvray ID, Chan WC
Can J Gastroenterol Hepatol. 2016;2016:5743521
Sagan SM, Dupont B, Grebely J, Krajden M, MacParland SA, Raven JF, Saeed S, Feld JJ, Tyrrell DL, Wilson JA
PLoS One. 2016;11(4):e0154433
MacParland SA, Fadel SM, Mihajlovic V, Fawaz A, Kim C, Rahman AK, Liu J, Kaul R, Kovacs C, Grebely J, Dore GJ, Wong DK, Ostrowski MA
J Virol. 2016 Jun 15;90(12):5549-60
MacParland SA, Ma XZ, Chen L, Khattar R, Cherepanov V, Selzner M, Feld JJ, Selzner N, McGilvray ID
Virol J. 2015 Jun 19;12:93
MacParland SA, Chen AY, Corkum CP, Pham TN, Michalak TI
Can J Gastroenterol Hepatol. 2014 Oct;28(9):481-7
MacParland SA, Bilodeau M, Grebely J, Bruneau J, Cooper C, Klein M, Sagan S, Choucha N, Balfour L, Bialystok F, Krajden M, Raven J, Roberts E, Russell R, Houghton M, Tyrrell DL, Feld JJ, National CIHR Research Training Program in Hepatitis C

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Assistant Professor, Departments of Laboratory Medicine and Pathobiology (LMP) and Immunology, University of Toronto