Sarah Q. Crome, PhD

A fundamental feature of the immune system is the ability to maintain immune homeostasis. Loss of tolerance to self or innocuous foreign antigens can result in autoimmune diseases or transplant rejection, respectively. On the other hand, inappropriate tolerance to antigens such as those present in tumor cells or viruses, can result in loss of tumor immunity or an inability to resolve infectious diseases. Immune responses are tightly regulated at the molecular level, through cellular interactions, and by the microenvironment. Identifying these mechanisms offers the potential to develop more precise immunotherapies for a wide range of dysregulated immune responses. The Crome Lab is focused on delineating regulatory mechanisms which control T cell responses, with a particular focus on innate lymphoid cells and regulatory T cells.

Current projects in the Crome Lab are focused on:
1. Development and engineering of regulatory populations of innate lymphoid cells
2. Mechanism used by innate lymphoid cells to regulate T cell responses
3. Studying tissue-resident lymphocytes in humans
4. Development of immunotherapies for transplantation

J Immunother Cancer. 2018 Nov 19;6(1):121
Crome SQ, Ohashi PS
Nat Med. 2017 Mar;23(3):368-375
Crome SQ, Nguyen LT, Lopez-Verges S, Yang SY, Martin B, Yam JY, Johnson DJ, Nie J, Pniak M, Yen PH, Milea A, Sowamber R, Katz SR, Bernardini MQ, Clarke BA, Shaw PA, Lang PA, Berman HK, Pugh TJ, Lanier LL, Ohashi PS
Cell Death Differ. 2014 Jul;21(7):1050-60
Grusdat M, McIlwain DR, Xu HC, Pozdeev VI, Knievel J, Crome SQ, Robert-Tissot C, Dress RJ, Pandyra AA, Speiser DE, Lang E, Maney SK, Elford AR, Hamilton SR, Scheu S, Pfeffer K, Bode J, Mittrücker HW, Lohoff M, Huber M, Häussinger D, Ohashi PS, Mak TW,...
Trends Immunol. 2013 Jul;34(7):342-9
Crome SQ, Lang PA, Lang KS, Ohashi PS
J Immunol. 2011 Dec 01;187(11):5615-26
Cohen CJ, Crome SQ, MacDonald KG, Dai EL, Mager DL, Levings MK
Eur J Immunol. 2011 Feb;41(2):306-12
Himmel ME, Crome SQ, Ivison S, Piccirillo C, Steiner TS, Levings MK
Cancer Immunol Immunother. 2011 Mar;60(3):381-8
Wang AY, Crome SQ, Jenkins KM, Medin JA, Bramson JL, Levings MK
J Immunol. 2010 Oct 01;185(7):3814-8
Marwaha AK, Crome SQ, Panagiotopoulos C, Berg KB, Qin H, Ouyang Q, Xu L, Priatel JJ, Levings MK, Tan R
J Immunol. 2010 Sep 15;185(6):3199-208
Crome SQ, Clive B, Wang AY, Kang CY, Chow V, Yu J, Lai A, Ghahary A, Broady R, Levings MK
Eur J Immunol. 2010 Aug;40(8):2174-81
Maggi L, Santarlasci V, Capone M, Peired A, Frosali F, Crome SQ, Querci V, Fambrini M, Liotta F, Levings MK, Maggi E, Cosmi L, Romagnani S, Annunziato F

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Assistant Professor, Department of Immunology, Faculty of Medicine, University of Toronto