Richard D Weisel, BA, MD

I have three major areas of research interests: cell transplantation, myocardial protection and vascular biology.
  • Cell Transplantation
    Over the last ten years, we have carefully evaluated alternative techniques to regenerate the heart after injury. We employed heart cells and adult bone marrow stem cells to regenerate the heart. We also investigated techniques to induce angiogenesis for patients who are unable to have conventional coronary bypass surgery. Finally, we have developed techniques to replace portions of the heart with tissue-engineered autologous cell-seeded grafts.
  • Myocardial Protection
    We have evaluated adenosine, insulin and L-arginine as agents which protect the myocardium from ischemic and reperfusion injury. We have performed studies in cell cultures, small and large animals and in patients undergoing coronary bypass surgery.
  • Vascular Biology
    We evaluated a variety of agents which will prevent intimal hyperplasia and restore normal endothelial function after coronary interventions.

Related Links

 
Am J Physiol Heart Circ Physiol. 2018 Jun 27;:
Alibhai FJ, Tobin SW, Yeganeh A, Weisel RD, Li RK
Theranostics. 2018;8(10):2752-2764
Cui Z, Ni NC, Wu J, Du GQ, He S, Yau TM, Weisel RD, Sung HW, Li RK
Am J Physiol Heart Circ Physiol. 1998 Nov 01;275(5):H1673-H1681
Merante F, Mickle DAG, Weisel RD, Li RK, Tumiati LC, Rao V, Williams WG, Robinson BH
Theranostics. 2018;8(7):1766-1781
Li J, Li SH, Wu J, Weisel RD, Yao A, Stanford WL, Liu SM, Li RK
J Heart Lung Transplant. 2017 Dec 20;:
He S, Song H, Wu J, Li SH, Weisel RD, Sung HW, Li J, Li RK
Ann Thorac Surg. 2017 Dec 06;:
Perrault LP, Kirkwood KA, Chang HL, Mullen JC, Gulack BC, Argenziano M, Gelijns AC, Ghanta RK, Whitson BA, Williams DL, Sledz-Joyce NM, Lima B, Greco G, Fumakia N, Rose EA, Puskas JD, Blackstone EH, Weisel RD, Bowdish ME
J Thorac Cardiovasc Surg. 2017 Dec;154(6):1938-1956
O'Gara PT, Sundt TM, Acker MA, David TE, Michler RE, Borger MA, Ailawadi G, Thourani VH, Gillinov AM, Damiano RJ, Mack MJ, Lee R, Rose EA, Gardner TJ, Miller MA, Weisel RD, Gelijns AC
J Thorac Cardiovasc Surg. 2017 Nov;154(5):1475-1476
Weisel RD
JAMA. 2017 Aug 08;318(6):536-547
Mack MJ, Acker MA, Gelijns AC, Overbey JR, Parides MK, Browndyke JN, Groh MA, Moskowitz AJ, Jeffries NO, Ailawadi G, Thourani VH, Moquete EG, Iribarne A, Voisine P, Perrault LP, Bowdish ME, Bilello M, Davatzikos C, Mangusan RF, Winkle RA, Smith PK,...
Ann Thorac Surg. 2017 Apr;103(4):1350-1356
Bakaeen FG, Svensson LG, Mitchell JD, Keshavjee S, Patterson GA, Weisel RD

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Professor of Cardiac Surgery, University of Toronto