I have three major areas of research interests: cell transplantation, myocardial protection and vascular biology.
- Cell TransplantationOver the last ten years, we have carefully evaluated alternative techniques to regenerate the heart after injury. We employed heart cells and adult bone marrow stem cells to regenerate the heart. We also investigated techniques to induce angiogenesis for patients who are unable to have conventional coronary bypass surgery. Finally, we have developed techniques to replace portions of the heart with tissue-engineered autologous cell-seeded grafts.
- Myocardial ProtectionWe have evaluated adenosine, insulin and L-arginine as agents which protect the myocardium from ischemic and reperfusion injury. We have performed studies in cell cultures, small and large animals and in patients undergoing coronary bypass surgery.
- Vascular BiologyWe evaluated a variety of agents which will prevent intimal hyperplasia and restore normal endothelial function after coronary interventions.
J Thorac Cardiovasc Surg. 2019 Sep;158(3):820-821
Long-term repopulation of aged bone marrow stem cells using young Sca-1 cells promotes aged heart rejuvenation.
Aging Cell. 2019 Aug 05;:e13026
J Mol Cell Cardiol. 2019 Apr 29;:
J Mol Cell Cardiol. 2019 Apr 29;132:71-83
Intramyocardial Injection of Mesenchymal Precursor Cells and Successful Temporary Weaning From Left Ventricular Assist Device Support in Patients With Advanced Heart Failure: A Randomized Clinical Trial.
JAMA. 2019 03 26;321(12):1176-1186
The Aggressive Cholesterol Therapy to Inhibit Vein Graft Events trial: To continue or not? How to answer the question.
J Thorac Cardiovasc Surg. 2018 Oct 09;:
Young bone marrow Sca-1 cells protect aged retina from ischaemia-reperfusion injury through activation of FGF2.
J Cell Mol Med. 2018 Sep 25;:
Aged Human Multipotent Mesenchymal Stromal Cells Can Be Rejuvenated by Neuron-Derived Neurotrophic Factor and Improve Heart Function After Injury.
JACC Basic Transl Sci. 2017 Dec;2(6):702-716
Am J Physiol Heart Circ Physiol. 2018 Jun 27;:
Polypyrrole-chitosan conductive biomaterial synchronizes cardiomyocyte contraction and improves myocardial electrical impulse propagation.
Emeritus Scientist, Toronto General Hospital Research Institute (TGHRI)
Professor of Cardiac Surgery, University of Toronto