Richard D Weisel, BA, MD

I have three major areas of research interests: cell transplantation, myocardial protection and vascular biology.
  • Cell Transplantation
    Over the last ten years, we have carefully evaluated alternative techniques to regenerate the heart after injury. We employed heart cells and adult bone marrow stem cells to regenerate the heart. We also investigated techniques to induce angiogenesis for patients who are unable to have conventional coronary bypass surgery. Finally, we have developed techniques to replace portions of the heart with tissue-engineered autologous cell-seeded grafts.
  • Myocardial Protection
    We have evaluated adenosine, insulin and L-arginine as agents which protect the myocardium from ischemic and reperfusion injury. We have performed studies in cell cultures, small and large animals and in patients undergoing coronary bypass surgery.
  • Vascular Biology
    We evaluated a variety of agents which will prevent intimal hyperplasia and restore normal endothelial function after coronary interventions.

Related Links

 
J Mol Cell Cardiol. 2019 Apr 29;:
Yin W, Guo J, Zhang C, Alibhai FJ, Li SH, Billia P, Wu J, Yau TM, Weisel RD, Li RK
J Mol Cell Cardiol. 2019 Apr 29;132:71-83
Tobin SW, Alibhai FJ, Lee MM, Yeganeh A, Wu J, Li SH, Guo J, Tsang K, Tumiati L, Rocha R, Butany J, Yau TM, Ouzounian M, David TE, Weisel RD, Li RK
JAMA. 2019 03 26;321(12):1176-1186
Yau TM, Pagani FD, Mancini DM, Chang HL, Lala A, Woo YJ, Acker MA, Selzman CH, Soltesz EG, Kern JA, Maltais S, Charbonneau E, Pan S, Marks ME, Moquete EG, O'Sullivan KL, Taddei-Peters WC, McGowan LK, Green C, Rose EA, Jeffries N, Parides MK, Weisel RD,...
J Thorac Cardiovasc Surg. 2018 Oct 09;:
Moffatt-Bruce SD, D'Amico TA, Weisel RD, Sade RM
J Cell Mol Med. 2018 Sep 25;:
Shao Z, Wu J, Du G, Song H, Li SH, He S, Li J, Wu J, Weisel RD, Yuan H, Li RK
JACC Basic Transl Sci. 2017 Dec;2(6):702-716
Song HF, He S, Li SH, Yin WJ, Wu J, Guo J, Shao ZB, Zhai XY, Gong H, Lu L, Wei F, Weisel RD, Xie J, Li RK
Am J Physiol Heart Circ Physiol. 2018 Jun 27;:
Alibhai FJ, Tobin SW, Yeganeh A, Weisel RD, Li RK
Theranostics. 2018;8(10):2752-2764
Cui Z, Ni NC, Wu J, Du GQ, He S, Yau TM, Weisel RD, Sung HW, Li RK
Am J Physiol Heart Circ Physiol. 1998 Nov 01;275(5):H1673-H1681
Merante F, Mickle DAG, Weisel RD, Li RK, Tumiati LC, Rao V, Williams WG, Robinson BH
Theranostics. 2018;8(7):1766-1781
Li J, Li SH, Wu J, Weisel RD, Yao A, Stanford WL, Liu SM, Li RK

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Professor of Cardiac Surgery, University of Toronto