Richard D Weisel

Richard D Weisel, BA, MD

I have three major areas of research interests: cell transplantation, myocardial protection and vascular biology.
  • Cell Transplantation
    Over the last ten years, we have carefully evaluated alternative techniques to regenerate the heart after injury. We employed heart cells and adult bone marrow stem cells to regenerate the heart. We also investigated techniques to induce angiogenesis for patients who are unable to have conventional coronary bypass surgery. Finally, we have developed techniques to replace portions of the heart with tissue-engineered autologous cell-seeded grafts.
  • Myocardial Protection
    We have evaluated adenosine, insulin and L-arginine as agents which protect the myocardium from ischemic and reperfusion injury. We have performed studies in cell cultures, small and large animals and in patients undergoing coronary bypass surgery.
  • Vascular Biology
    We evaluated a variety of agents which will prevent intimal hyperplasia and restore normal endothelial function after coronary interventions.

Related Links

 
JAMA. 2017 Aug 08;318(6):536-547
Mack MJ, Acker MA, Gelijns AC, Overbey JR, Parides MK, Browndyke JN, Groh MA, Moskowitz AJ, Jeffries NO, Ailawadi G, Thourani VH, Moquete EG, Iribarne A, Voisine P, Perrault LP, Bowdish ME, Bilello M, Davatzikos C, Mangusan RF, Winkle RA, Smith PK,...
Ann Thorac Surg. 2017 Apr;103(4):1350-1356
Bakaeen FG, Svensson LG, Mitchell JD, Keshavjee S, Patterson GA, Weisel RD
J Thorac Cardiovasc Surg. 2017 Apr;153(4):999-1005
Bakaeen FG, Svensson LG, Mitchell JD, Keshavjee S, Patterson GA, Weisel RD
FASEB J. 2017 Mar 23;:
Tobin SW, Li SH, Li J, Wu J, Yeganeh A, Yu P, Weisel RD, Li RK
Semin Thorac Cardiovasc Surg. 2016 Autumn;28(3):609-610
Rosengart TK, Austin EH, Pass HI, Weisel RD
Sci Rep. 2017 Jan 31;7:41756
Li SH, Sun L, Yang L, Li J, Shao Z, Du GQ, Wu J, Weisel RD, Li RK
J Thorac Cardiovasc Surg. 2017 Feb;153(2):S2
Coselli JS, Weisel RD
J Thorac Cardiovasc Surg. 2017 Jan;153(1):1
Weisel RD
J Tissue Eng Regen Med. 2016 Sep 30;
Iijima M, Aubin H, Steinbrink M, Schiffer F, Assmann A, Weisel RD, Matsui Y, Li RK, Lichtenberg A, Akhyari P
Acta Biomater. 2016 Sep 12;
Rodness J, Mihic A, Miyagi Y, Wu J, Weisel RD, Li RK

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Professor of Cardiac Surgery, University of Toronto