I have three major areas of research interests: cell transplantation, myocardial protection and vascular biology.
Richard D Weisel
- Cell TransplantationOver the last ten years, we have carefully evaluated alternative techniques to regenerate the heart after injury. We employed heart cells and adult bone marrow stem cells to regenerate the heart. We also investigated techniques to induce angiogenesis for patients who are unable to have conventional coronary bypass surgery. Finally, we have developed techniques to replace portions of the heart with tissue-engineered autologous cell-seeded grafts.
- Myocardial ProtectionWe have evaluated adenosine, insulin and L-arginine as agents which protect the myocardium from ischemic and reperfusion injury. We have performed studies in cell cultures, small and large animals and in patients undergoing coronary bypass surgery.
- Vascular BiologyWe evaluated a variety of agents which will prevent intimal hyperplasia and restore normal endothelial function after coronary interventions.
Bio-active coating of decellularized vascular grafts with a temperature-sensitive VEGF-conjugated hydrogel accelerates autologous endothelialization in vivo.
J Tissue Eng Regen Med. 2016 Sep 30;
Acta Biomater. 2016 Sep 12;
Can J Anaesth. 1992 May;39(Suppl 1):A3-A151
J Am Coll Cardiol. 2016 Jun 28;67(25):2965-77
Class II transactivator knockdown limits major histocompatibility complex II expression, diminishes immune rejection, and improves survival of allogeneic bone marrow stem cells in the infarcted heart.
FASEB J. 2016 May 24;
Eur J Cardiothorac Surg. 2016 May 4;
N Engl J Med. 2016 Apr 4;
N Engl J Med. 2016 Apr 3;
Mast cells promote proliferation and migration and inhibit differentiation of mesenchymal stem cells through PDGF.
J Mol Cell Cardiol. 2016 Mar 17;
J Thorac Cardiovasc Surg. 2016 Jan 23;
Physician, Monthly Stipend, Toronto General Research Institute (TGRI)
Professor of Cardiac Surgery, University of Toronto