Richard D Weisel

Richard D Weisel, BA, MD

I have three major areas of research interests: cell transplantation, myocardial protection and vascular biology.
  • Cell Transplantation
    Over the last ten years, we have carefully evaluated alternative techniques to regenerate the heart after injury. We employed heart cells and adult bone marrow stem cells to regenerate the heart. We also investigated techniques to induce angiogenesis for patients who are unable to have conventional coronary bypass surgery. Finally, we have developed techniques to replace portions of the heart with tissue-engineered autologous cell-seeded grafts.
  • Myocardial Protection
    We have evaluated adenosine, insulin and L-arginine as agents which protect the myocardium from ischemic and reperfusion injury. We have performed studies in cell cultures, small and large animals and in patients undergoing coronary bypass surgery.
  • Vascular Biology
    We evaluated a variety of agents which will prevent intimal hyperplasia and restore normal endothelial function after coronary interventions.

Related Links

 
Acta Biomater. 2016 Sep 12;
Rodness J, Mihic A, Miyagi Y, Wu J, Weisel RD, Li RK
Can J Anaesth. 1992 May;39(Suppl 1):A3-A151
Michèle S, Alain B, Oliver WS, Hung OR, Hope CE, Laney G, Whynot SC, Coonan TJ, Malloy DS, Patterson S, Gelb A, Manninen P, Strum D, Glosten B, Spellman MJ, Eger EI, Craen RA, Gelb AW, Murkin JM, Chong KY, Penning DH, El-Behairy H, Brien JF, Coh JW,...
J Am Coll Cardiol. 2016 Jun 28;67(25):2965-77
Wu J, Song HF, Li SH, Guo J, Tsang K, Tumiati L, Butany J, Yau TM, Ouzounian M, Fu S, David TE, Weisel RD, Li RK
Eur J Cardiothorac Surg. 2016 May 4;
Weisel RD
N Engl J Med. 2016 Apr 4;
Gillinov AM, Bagiella E, Moskowitz AJ, Raiten JM, Groh MA, Bowdish ME, Ailawadi G, Kirkwood KA, Perrault LP, Parides MK, Smith Ii RL, Kern JA, Dussault G, Hackmann AE, Jeffries NO, Miller MA, Taddei-Peters WC, Rose EA, Weisel RD, Williams DL, Mangusan...
N Engl J Med. 2016 Apr 3;
Michler RE, Smith PK, Parides MK, Ailawadi G, Thourani V, Moskowitz AJ, Acker MA, Hung JW, Chang HL, Perrault LP, Gillinov AM, Argenziano M, Bagiella E, Overbey JR, Moquete EG, Gupta LN, Miller MA, Taddei-Peters WC, Jeffries N, Weisel RD, Rose EA,...
J Mol Cell Cardiol. 2016 Mar 17;
Nazari M, Ni NC, Ludke A, Li SH, Guo J, Weisel RD, Li RK
J Thorac Cardiovasc Surg. 2016 Jan 23;
Svensson LG, Gillinov AM, Weisel RD, Keshavjee S, Bacha EA, Moon MR, Cameron DE, Sugarbaker DJ, Adams DH, Gaynor JW, Coselli JS, Del Nido PJ, Jones D, Sundt TM, Cohn LH, Pomar JL, Lytle BW, Schaff HV
Semin Thorac Cardiovasc Surg. 2015;27(4):339-40
Rosengart TK, Austin EH, Pass HI, Weisel RD

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Professor of Cardiac Surgery, University of Toronto