Ralph S. DaCosta, PhD

Scientist, Princess Margaret Cancer Centre
Research Faculty, Techna Institute for the Advancement of Technology for Health (Techna)
Keywords: image-guided radiotherapy, image-guided therapy, medical imaging, fluorescence imaging, photodynamic therapy, optical technologies
  • Monitoring tumour response to radiation therapy in real-time
  • Detecting cancers earlier with fluorescence endoscopy
  • Detecting bacterial infection in chronic wounds with light
  • Optical molecular imaging applied to stem cell and regenerative medicine
  • Optical molecular imaging applied to neuroscience and neutological disease
  • New technologies for image-guided and minimally-invasive surgery
  • New advances in 3D fluorescence image-guided cancer surgery
Intravital imaging for tracking of angiogenesis and cellular events around surgical bone implants.
Tissue Eng Part C Methods. 2018 Oct 03;:
Khosravi N, Mendes VV, Nirmal G, Majeed S, DaCosta RS, Davies JE
Nanosurfaces modulate the mechanism of peri-implant endosseous healing by regulating neovascular morphogenesis.
Commun Biol. 2018;1:72
Khosravi N, Maeda A, DaCosta RS, Davies JE
Improved detection of clinically relevant wound bacteria using autofluorescence image-guided sampling in diabetic foot ulcers.
Int Wound J. 2017 Feb 28;:
Ottolino-Perry K, Chamma E, Blackmore KM, Lindvere-Teene L, Starr D, Tapang K, Rosen CF, Pitcher B, Panzarella T, Linden R, DaCosta RS
The Necrosis-Avid Small Molecule HQ4-DTPA as a Multimodal Imaging Agent for Monitoring Radiation Therapy-Induced Tumor Cell Death.
Front Oncol. 2016;6:221
Stammes MA, Maeda A, Bu J, Scollard DA, Kulbatski I, Medeiros PJ, Sinisi R, Dubikovskaya EA, Snoeks TJ, van Beek ER, Chan AB, Löwik CW, DaCosta RS
In Vivo Imaging Reveals Significant Tumor Vascular Dysfunction and Increased Tumor Hypoxia-Inducible Factor-1α Expression Induced by High Single-Dose Irradiation in a Pancreatic Tumor Model.
Int J Radiat Oncol Biol Phys. 2016 Sep 14;:
Maeda A, Chen Y, Bu J, Mujcic H, Wouters BG, DaCosta RS
Hybrid manganese dioxide nanoparticles potentiate radiation therapy by modulating tumor hypoxia.
Cancer Res. 2016 Oct 6;:
Abbasi AZ, Gordijo CR, Amini MA, Maeda A, Rauth AM, DaCosta RS, Wu XY
Can Imaging Put the "Advanced" Back in Advanced Wound Care?
Adv Wound Care (New Rochelle). 2016 Aug 1;5(8):329-331
DaCosta RS, Ottolino-Perry K, Banerjee J
Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis Imaging.
Mol Imaging Biol. 2016 Jun 8;
Stammes MA, Knol-Blankevoort VT, Cruz LJ, Feitsma HR, Mezzanotte L, Cordfunke RA, Sinisi R, Dubikovskaya EA, Maeda A, DaCosta RS, Bierau K, Chan A, Kaijzel EL, Snoeks TJ, van Beek ER, Löwik CW
Emerging Applications for Optically Enabled Intravital Microscopic Imaging in Radiobiology.
Mol Imaging. 2015 Sep 1;14:452-74
Maeda A, Kulbatski I, DaCosta RS
Optically-tracked handheld fluorescence imaging platform for monitoring skin response in the management of soft tissue sarcoma.
J Biomed Opt. 2015 Jul 1;20(7):76011
Chamma E, Qiu J, Lindvere-Teene L, Blackmore KM, Majeed S, Weersink R, Dickie CI, Griffin AM, Wunder JS, Ferguson PC, DaCosta RS

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Scientist, Princess Margaret Cancer Centre
Research Faculty, Techna Institute for the Advancement of Technology for Health (Techna)

Cancer Care Ontario Research Chair in Cancer Imaging
UHN Biophotonics Program
Member, Radiation Medicine Program
Member, Spatio-Temporal Targeted and Amplification of Radiation Response (STTARR) Innovation Center​