Ralph S. DaCosta

Ralph S. DaCosta, PhD

Scientist, Princess Margaret Cancer Centre
Keywords: image-guided radiotherapy, image-guided therapy, medical imaging, fluorescence imaging, photodynamic therapy, optical technologies
  • Monitoring tumour response to radiation therapy in real-time
  • Detecting cancers earlier with fluorescence endoscopy
  • Detecting bacterial infection in chronic wounds with light
  • Optical molecular imaging applied to stem cell and regenerative medicine
  • Optical molecular imaging applied to neuroscience and neutological disease
  • New technologies for image-guided and minimally-invasive surgery
  • New advances in 3D fluorescence image-guided cancer surgery
Can Imaging Put the "Advanced" Back in Advanced Wound Care?
Adv Wound Care (New Rochelle). 2016 Aug 1;5(8):329-331
DaCosta RS, Ottolino-Perry K, Banerjee J
Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis Imaging.
Mol Imaging Biol. 2016 Jun 8;
Stammes MA, Knol-Blankevoort VT, Cruz LJ, Feitsma HR, Mezzanotte L, Cordfunke RA, Sinisi R, Dubikovskaya EA, Maeda A, DaCosta RS, Bierau K, Chan A, Kaijzel EL, Snoeks TJ, van Beek ER, Löwik CW
Emerging Applications for Optically Enabled Intravital Microscopic Imaging in Radiobiology.
Mol Imaging. 2015 Sep 1;14:452-74
Maeda A, Kulbatski I, DaCosta RS
Optically-tracked handheld fluorescence imaging platform for monitoring skin response in the management of soft tissue sarcoma.
J Biomed Opt. 2015 Jul 1;20(7):76011
Chamma E, Qiu J, Lindvere-Teene L, Blackmore KM, Majeed S, Weersink R, Dickie CI, Griffin AM, Wunder JS, Ferguson PC, DaCosta RS
Handheld fluorescence imaging device detects subclinical wound infection in an asymptomatic patient with chronic diabetic foot ulcer: a case report.
Int Wound J. 2015 Apr 22;
Wu YC, Smith M, Chu A, Lindvere-Teene L, Starr D, Tapang K, Shekhman R, Wong O, Linden R, DaCosta RS
Point-of-Care Autofluorescence Imaging for Real-Time Sampling and Treatment Guidance of Bioburden in Chronic Wounds: First-in-Human Results.
PLoS One. 2015;10(3):e0116623
DaCosta RS, Kulbatski I, Lindvere-Teene L, Starr D, Blackmore K, Silver JI, Opoku J, Wu YC, Medeiros PJ, Xu W, Xu L, Wilson BC, Rosen C, Linden R
Dual In Vivo Photoacoustic and Fluorescence Imaging of HER2 Expression in Breast Tumors for Diagnosis, Margin Assessment, and Surgical Guidance.
Mol Imaging. 2014 Nov 1;13(0):1-9
Maeda A, Bu J, Chen J, Zheng G, DaCosta RS
Autofluorescence imaging device for real-time detection and tracking of pathogenic bacteria in a mouse skin wound model: preclinical feasibility studies.
J Biomed Opt. 2014 Aug;19(8):085002
Wu YC, Kulbatski I, Medeiros PJ, Maeda A, Bu J, Xu L, Chen Y, DaCosta RS
Multifunctional albumin-MnO₂ nanoparticles modulate solid tumor microenvironment by attenuating hypoxia, acidosis, vascular endothelial growth factor and enhance radiation response.
ACS Nano. 2014 Apr 22;8(4):3202-12
Prasad P, Gordijo CR, Abbasi AZ, Maeda A, Ip A, Rauth AM, DaCosta RS, Wu XY
Tumor vascularization is critical for oncolytic vaccinia virus treatment of peritoneal carcinomatosis.
Int J Cancer. 2014 Feb 1;134(3):717-30
Ottolino-Perry K, Tang N, Head R, Ng C, Arulanandam R, Angarita FA, Acuna SA, Chen Y, Bell J, Dacosta RS, McCart JA

Pages
Scientist, Princess Margaret Cancer Centre

Cancer Care Ontario Research Chair in Cancer Imaging
UHN Biophotonics Program
Member, Radiation Medicine Program
Member, Spatio-Temporal Targeted and Amplification of Radiation Response (STTARR) Innovation Center​