Pamela S Ohashi, PhD, FRSC


My lab has focused on understanding the mechanisms that determine whether T cells are activated or tolerized in vivo. We use a variety of transgenic and gene knock out mouse models to evaluate the molecular pathways that govern T cell fate. In particular, we examine how to promote T cell responses to tissues, with a goal to understand and control autoimmune and anti-tumor immune responses.

Our recent studies have examined novel ways that dendritic cells are programmed to influence T cell function in vivo. In addition we are focused on how the tissue or tumor microenvironment can have a significant impact on T cell responses.

Importantly, my interests have also expanded to establishing an immune therapy platform. My group has developed the ability to grow tumor infiltrating T cells and characterize their properties. We have also coordinated clinical trials and are building towards a comprehensive program in immune therapy.
 
Cell Rep. 2018 Jul 31;24(5):1123-1135
Dimitriou ID, Lee K, Akpan I, Lind EF, Barr VA, Ohashi PS, Samelson LE, Rottapel R
Clin Cancer Res. 2018 Jul 31;:
Toker A, Nguyen LT, Stone SC, Yang C, Katz SR, Shaw PA, Clarke BA, Ghazarian DA, Al Habeeb AS, Easson AM, Leong W, McCready D, Reedijk M, Guidos CJ, Pugh TJ, Bernardini MQ, Ohashi PS
ACS Nano. 2018 Jul 13;:
Stapleton S, Dunne M, Milosevic M, Tran CW, Gold MJ, Vedadi A, McKee T, Ohashi PS, Allen C, Jaffray DA
Lancet. 2018 May 10;:
Pagès F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, Lugli A, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Börger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grützmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Léonard D, Remue C,...
Eur J Cancer. 2018 Apr 06;95:38-51
Iafolla MAJ, Selby H, Warner K, Ohashi PS, Haibe-Kains B, Siu LL
J Immunol. 2017 Dec 01;199(11):3717-3720
Mittrücker HW, Matsuyama T, Grossman A, Kündig TM, Potter J, Shahinian A, Wakeham A, Patterson B, Ohashi PS, Mak TW
J Immunol. 2017 Nov 06;:
Tran CW, Saibil SD, Le Bihan T, Hamilton SR, Lang KS, You H, Lin AE, Garza KM, Elford AR, Tai K, Parsons ME, Wigmore K, Vainberg MG, Penninger JM, Woodgett JR, Mak TW, Ohashi PS
Cancer Discov. 2017 Aug 08;:
Shen Q, Cohen B, Zheng W, Rahbar R, Martin B, Murakami K, Lamorte S, Thompson P, Berman H, Zúñiga-Pflücker JC, Ohashi PS, Reedijk M
Eur J Nucl Med Mol Imaging. 2017 Apr 10;:
Lheureux S, Denoyelle C, Ohashi PS, De Bono JS, Mottaghy FM
Science. 2017 Mar 31;355(6332):1373-1374
Clouthier DL, Ohashi PS

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Canada Research Chair in Autoimmunity and Tumour Immunity
Professor, Department of Immunology, Faculty of Medicine, University of Toronto
Professor, Department of Medical Biophysics, Faculty of Medicine, University of Toronto