My lab is focused on understanding the mechanisms that regulate T cell activation and function. As an overarching theme, we examine ways to promote T cell responses to tissues, with a goal to understand and control autoimmune and antitumour immune responses. My group has developed the ability to grow tumour-infiltrating T cells, characterize their properties and develop therapies based on this population of cells. This expertise and technology has also led to the identification of novel cell subsets as well as providing a platform to identify and generate novel tools for immunotherapy. We are also characterizing the immune status of various tumours to understand how best to tailor combination therapies in clinical trials. Recently, we have been the first to identify a novel population of Innate lymphoid cells that play a key role in immunoregulation and limit the expansion of tumour-infiltrating lymphocytes.
Senior Scientist, Princess Margaret Cancer Centre
Canada Research Chair in Autoimmunity and Tumour Immunity
Director, Tumor Immunotherapy Program
Professor, Department of Immunology, Faculty of Medicine, University of Toronto
Professor, Department of Medical Biophysics, Faculty of Medicine, University of Toronto