Pamela S Ohashi

Pamela S Ohashi, PhD, FRSC


My lab has focused on understanding the mechanisms that determine whether T cells are activated or tolerized in vivo. We use a variety of transgenic and gene knock out mouse models to evaluate the molecular pathways that govern T cell fate. In particular, we examine how to promote T cell responses to tissues, with a goal to understand and control autoimmune and anti-tumor immune responses.

Our recent studies have examined novel ways that dendritic cells are programmed to influence T cell function in vivo. In addition we are focused on how the tissue or tumor microenvironment can have a significant impact on T cell responses.

Importantly, my interests have also expanded to establishing an immune therapy platform. My group has developed the ability to grow tumor infiltrating T cells and characterize their properties. We have also coordinated clinical trials and are building towards a comprehensive program in immune therapy.
 
J Immunother Cancer. 2016;4:37
Kaufman HL, Butterfield LH, Coulie PG, Demaria S, Ferris RL, Galon J, Khleif SN, Mellman I, Ohashi PS, Overwijk WW, Topalian SL, Marincola FM
Oncoimmunology. 2016;5(1):e1050575
Rahbar R, Ohashi PS
Nat Immunol. 2016 Jan 19;17(2):115-116
Millar DG, Ohashi PS
J Immunol. 2015 Oct 12;
Ng D, Maître B, Cummings D, Lin A, Ward LA, Rahbar R, Mossman KL, Ohashi PS, Gommerman JL
J Immunol. 2015 Oct 7;
Lind EF, Millar DG, Dissanayake D, Savage JC, Grimshaw NK, Kerr WG, Ohashi PS
Cell Death Differ. 2015 Apr 17;
Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF, Brenner D, Harris IS, Chio II, Afzal S, Cairns RA, Cescon DW, Elford AR, Ye J, Lang PA, Li WY, Wakeham A, Duncan GS, Haight J, You-Ten A, Snow B, Yamamoto K, Ohashi PS, Mak TW
J Immunol. 2015 Mar 11;
Bornancin F, Renner F, Touil R, Sic H, Kolb Y, Touil-Allaoui I, Rush JS, Smith PA, Bigaud M, Junker-Walker U, Burkhart C, Dawson J, Niwa S, Katopodis A, Nuesslein-Hildesheim B, Weckbecker G, Zenke G, Kinzel B, Traggiai E, Brenner D, Brüstle A, St Paul...
J Virol. 2015 Feb 11;
Xu HC, Huang J, Khairnar V, Duhan V, Pandyra AA, Grusdat M, Shinde P, McIlwain DR, Maney SK, Gommerman J, Löhning M, Ohashi PS, Mak TW, Pieper K, Sic H, Speletas M, Eibel H, Ware CF, Tumanov AV, Kruglov AA, Nedospasov SA, Häusinger D, Recher M, Lang KS...
Nat Rev Immunol. 2014 Dec 23;15(1):45-56
Nguyen LT, Ohashi PS
Cancer Immunol Res. 2014 Dec 19;
Rahbar R, Lin A, Ghazarian M, Loo Yau H, Paramathas S, Lang P, Schildknecht A, Elford A, Garcia-Batres C, Martin B, Berman HK, Leong W, McCready D, Reedijk MJ, Done SJ, Miller N, Youngson B, Suh W, Mak TW, Ohashi PS

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Canada Research Chair in Autoimmunity and Tumour Immunity
Professor, Department of Immunology, Faculty of Medicine, University of Toronto
Professor, Department of Medical Biophysics, Faculty of Medicine, University of Toronto