Pamela S Ohashi

Pamela S Ohashi, PhD, FRSC


My lab has focused on understanding the mechanisms that determine whether T cells are activated or tolerized in vivo. We use a variety of transgenic and gene knock out mouse models to evaluate the molecular pathways that govern T cell fate. In particular, we examine how to promote T cell responses to tissues, with a goal to understand and control autoimmune and anti-tumor immune responses.

Our recent studies have examined novel ways that dendritic cells are programmed to influence T cell function in vivo. In addition we are focused on how the tissue or tumor microenvironment can have a significant impact on T cell responses.

Importantly, my interests have also expanded to establishing an immune therapy platform. My group has developed the ability to grow tumor infiltrating T cells and characterize their properties. We have also coordinated clinical trials and are building towards a comprehensive program in immune therapy.
 
J Immunol. 2017 Dec 01;199(11):3717-3720
Mittrücker HW, Matsuyama T, Grossman A, Kündig TM, Potter J, Shahinian A, Wakeham A, Patterson B, Ohashi PS, Mak TW
J Immunol. 2017 Nov 06;:
Tran CW, Saibil SD, Le Bihan T, Hamilton SR, Lang KS, You H, Lin AE, Garza KM, Elford AR, Tai K, Parsons ME, Wigmore K, Vainberg MG, Penninger JM, Woodgett JR, Mak TW, Ohashi PS
Cancer Discov. 2017 Aug 08;:
Shen Q, Cohen B, Zheng W, Rahbar R, Martin B, Murakami K, Lamorte S, Thompson P, Berman H, Zúñiga-Pflücker JC, Ohashi PS, Reedijk M
Eur J Nucl Med Mol Imaging. 2017 Apr 10;:
Lheureux S, Denoyelle C, Ohashi PS, De Bono JS, Mottaghy FM
Science. 2017 Mar 31;355(6332):1373-1374
Clouthier DL, Ohashi PS
Clin Cancer Res. 2017 Mar 21;:
MacGregor HL, Ohashi PS
PLoS One. 2017;12(3):e0173176
Ono N, Murakami K, Chan O, Hall H, Elford AR, Yen P, Calzascia T, Spencer DM, Ohashi PS, Dhanji S
Nat Med. 2017 Feb 06;:
Crome SQ, Nguyen LT, Lopez-Verges S, Yang SY, Martin B, Yam JY, Johnson DJ, Nie J, Pniak M, Yen PH, Milea A, Sowamber R, Katz SR, Bernardini MQ, Clarke BA, Shaw PA, Lang PA, Berman HK, Pugh TJ, Lanier LL, Ohashi PS
Nat Commun. 2017 Jan 13;8:14003
Hao Z, Sheng Y, Duncan GS, Li WY, Dominguez C, Sylvester J, Su YW, Lin GH, Snow BE, Brenner D, You-Ten A, Haight J, Inoue S, Wakeham A, Elford A, Hamilton S, Liang Y, Zúñiga-Pflücker JC, He HH, Ohashi PS, Mak TW
Nat Cell Biol. 2016 Oct 03;:
Zheng W, Umitsu M, Jagan I, Tran CW, Ishiyama N, BeGora M, Araki K, Ohashi PS, Ikura M, Muthuswamy SK

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Canada Research Chair in Autoimmunity and Tumour Immunity
Professor, Department of Immunology, Faculty of Medicine, University of Toronto
Professor, Department of Medical Biophysics, Faculty of Medicine, University of Toronto