Nizar N Mahomed, MPH, ScD, MD, FRCSC

Senior Scientist, Krembil Research Institute (Krembil)
Keywords: clinical trials, arthritis, total joint arthroplasty, knee joint, hip
The primary focus of research is the evaluation of process of care and outcomes of total joint arthroplasty. Residents will be given an opportunity to either develop a new study in collaboration with the research team or get involved with ongoing projects listed below:
  • Impact of rehabilitation post-total joint arthroplasty
  • Variations in regional rehabilitation services following total joint arthroplasty
  • Epidemiology of primary and revision arthroplasty
  • Determinants and impact of surgical volume on the outcomes of total joint arthroplasty; patient expectations regarding revision hip arthroplasty
  • Prospective randomized controlled trial of cemented vs. hybrid total hip arthroplasty
  • Prospective randomized controlled trial of PCL retaining vs. sacrificing total knee arthroplasty
  • Evaluations of the psychometric properties of hip rating systems
  • Determinants of outcomes following revision hip arthroplasty
  • Determinants of discharge destination post-total joint arthroplasty

Related Links

Associated Program(s)
microRNA-181a-5p antisense oligonucleotides attenuate osteoarthritis in facet and knee joints.
Ann Rheum Dis. 2018 Oct 04;:
Nakamura A, Rampersaud YR, Nakamura S, Sharma A, Zeng F, Rossomacha E, Ali SA, Krawetz R, Haroon N, Perruccio AV, Mahomed NN, Gandhi R, Rockel JS, Kapoor M
Presurgery osteoarthritis severity over 10 years in 2 Ontario prospective total knee replacement cohorts: a cohort study.
CMAJ Open. 2018 Jul-Sep;6(3):E269-E275
Davis AM, Ibrahim S, Hogg-Johnson S, Beaton DE, Chesworth BM, Gandhi R, Mahomed NN, Perruccio AV, Rajgopal V, Wong R, Waddell JP
Factors associated with the orthopaedic surgeon's decision to recommend total joint replacement in hip and knee osteoarthritis: an international cross-sectional study of 1905 patients.
Osteoarthritis Cartilage. 2018 Jul 11;:
Huynh C, Puyraimond-Zemmour D, Maillefert JF, Conaghan PG, Davis AM, Gunther KP, Hawker G, Hochberg MC, Kloppenburg M, Lim K, Lohmander LS, Mahomed NN, March L, Pavelka K, Punzi L, Roos EM, Sanchez-Riera L, Singh JA, Suarez-Almazor ME, Dougados M,...
Neuropathic pain in end-stage hip and knee osteoarthritis: differential associations with patient-reported pain at rest and pain on activity.
Osteoarthritis Cartilage. 2018 Jan 08;:
Power JD, Perruccio AV, Gandhi R, Veillette C, Davey JR, Syed K, Mahomed NN, Rampersaud YR
Understanding the Relationship Between 3-Month and 2-Year Pain and Function Scores After Total Knee Arthroplasty for Osteoarthritis.
J Arthroplasty. 2017 Dec 06;:
Gandhi R, Mahomed NN, Cram P, Perruccio AV
High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature.
Sci Rep. 2017 Aug 15;7(1):8205
Datta P, Zhang Y, Parousis A, Sharma A, Rossomacha E, Endisha H, Wu B, Kacprzak I, Mahomed NN, Gandhi R, Rockel JS, Kapoor M
Rate of and risk factors for intermediate-term reoperation after ankle fracture fixation: a population based, cohort study.
J Orthop Trauma. 2017 May 31;:
Pincus D, Veljkovic A, Zochowski T, Mahomed N, Ogilivie-Harris D, Wasserstein D
Systemic inflammation and painful joint burden in osteoarthritis: A Matter of Sex?
Osteoarthritis Cartilage. 2016 Aug 18;
Perruccio AV, Chandran V, Power JD, Kapoor M, Mahomed NN, Gandhi R
Study protocol for a pilot, randomised, double-blinded, placebo controlled trial of perineural local anaesthetics and steroids for chronic post-traumatic neuropathic pain in the ankle and foot: the PREPLANS study.
BMJ Open. 2016;6(6):e012293
Bhatia A, Bril V, Brull RT, Perruccio A, Wijeysundera D, Alvi S, Lau J, Gandhi R, Mahomed N, Davis AM
Identification of synovial fluid microRNA signature in knee osteoarthritis: differentiating early- and late-stage knee osteoarthritis.
Osteoarthritis Cartilage. 2016 Apr 30;
Li YH, Tavallaee G, Tokar T, Nakamura A, Sundararajan K, Weston A, Sharma A, Mahomed NN, Gandhi R, Jurisica I, Kapoor M

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Senior Scientist, Krembil Research Institute (Krembil)

Professor of Surgery, University of Toronto
Director, Arthritis Program, University Health Network
Managing Director, Altum Health, University Health Network