Michael Hoffman creates predictive computational models to understand interactions between genome, epigenome, and phenotype in human cancers. He implemented the genome annotation method Segway, which simplifies interpretation of large multivariate genomic datasets, and was a linchpin of the NIH ENCODE Project analysis. He is a principal investigator at the Princess Margaret Cancer Centre and Assistant Professor in the Departments of Medical Biophysics and Computer Science, University of Toronto. He was named a CIHR New Investigator and has received several awards for his academic work, including the NIH K99/R00 Pathway to Independence Award, and the Ontario Early Researcher Award. 

The Hoffman group develops machine learning techniques to better understand chromatin biology. These models and algorithms transform high-dimensional functional genomics data into interpretable patterns and lead to new biological insight.


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Genome Biol. 2019 08 28;20(1):180
Libbrecht MW, Rodriguez OL, Weng Z, Bilmes JA, Hoffman MM, Noble WS
J Cheminform. 2019 Apr 23;11(1):30
Sood AJ, Viner C, Hoffman MM
Inf Fusion. 2019 Oct;50:71-91
Zitnik M, Nguyen F, Wang B, Leskovec J, Goldenberg A, Hoffman MM
Nature. 2018 Nov 14;:
Shen SY, Singhania R, Fehringer G, Chakravarthy A, Roehrl MHA, Chadwick D, Zuzarte PC, Borgida A, Wang TT, Li T, Kis O, Zhao Z, Spreafico A, Medina TDS, Wang Y, Roulois D, Ettayebi I, Chen Z, Chow S, Murphy T, Arruda A, O'Kane GM, Liu J, Mansour M,...
Nucleic Acids Res. 2018 Aug 30;:
Karimzadeh M, Ernst C, Kundaje A, Hoffman MM
J R Soc Interface. 2018 Apr;15(141):
Ching T, Himmelstein DS, Beaulieu-Jones BK, Kalinin AA, Do BT, Way GP, Ferrero E, Agapow PM, Zietz M, Hoffman MM, Xie W, Rosen GL, Lengerich BJ, Israeli J, Lanchantin J, Woloszynek S, Carpenter AE, Shrikumar A, Xu J, Cofer EM, Lavender CA, Turaga SC,...
Proc Natl Acad Sci U S A. 2018 Feb 12;:
Denisko D, Hoffman MM
Bioinformatics. 2017 Sep 22;:
Chan RCW, Libbrecht MW, Roberts EG, Bilmes JA, Noble WS, Hoffman MM
Genome Biol. 2017 Jan 16;18(1):5
Chicco D, Hoffman MM
Brief Bioinform. 2017 Jan 14;:
Karimzadeh M, Hoffman MM



Assistant Professor, Department of Medical Biophysics, University of Toronto
Assistant Professor, Department of Computer Science, University of Toronto
Faculty Affiliate, Vector Institute
Member, Collaborative Graduate Program in Genome Biology and Bioinformatics, University of Toronto