Margaret S Herridge

Margaret S Herridge, BSc, MSc, MPH, MD, FRCPC

Scientist, Toronto General Research Institute (TGRI)
Keywords: quality of life, ICU-acquired weakness, neuropsychological dysfunction, clinical outcomes, critical illness, critical care
Our group is committed to evaluating and improving long-term patient and family caregiver outcomes after critical illness. To date, our research group's interests have included a study on the 5-year outcomes after the acute respiratory distress syndrome (ARDS), one-year outcomes in survivors of the severe acute respiratory syndrome (SARS) and long-stay, ventilated critically ill patients and their family caregivers. We are currently leading a 4-year multi-centre CIHR-funded study "Towards RECOVER" which will evaluate patient and caregiver outcomes to two years after prolonged mechanical ventilation and will help to inform a future family-centered rehabilitation program after severe critical illness.
Understanding patient-centredness: contrasting expert versus patient perspectives on vasopressor therapy for shock.
Intensive Care Med. 2016 Sep 13;
Lamontagne F, Cohen D, Herridge M
Early goal directed mobility in the ICU: 'something in the way you move'.
J Thorac Dis. 2016 Aug;8(8):E784-7
Dos Santos CC, Herridge M, Batt J
Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial-PROSPECT: a pilot trial.
Trials. 2016;17:377
Cook DJ, Johnstone J, Marshall JC, Lauzier F, Thabane L, Mehta S, Dodek PM, McIntyre L, Pagliarello J, Henderson W, Taylor RW, Cartin-Ceba R, Golan E, Herridge M, Wood G, Ovakim D, Karachi T, Surette MG, Bowdish DM, Lamarche D, Verschoor CP, Duan EH,...
Variation in diurnal sedation in mechanically ventilated patients who are managed with a sedation protocol alone or a sedation protocol and daily interruption.
Crit Care. 2016;20(1):233
Mehta S, Meade M, Burry L, Mallick R, Katsios C, Fergusson D, Dodek P, Burns K, Herridge M, Devlin JW, Tanios M, Fowler R, Jacka M, Skrobik Y, Olafson K, Cook D, SLEAP Investigators and the Canadian Critical Care Trials Group
Transcriptomic analysis reveals abnormal muscle repair and remodeling in survivors of critical illness with sustained weakness.
Sci Rep. 2016;6:29334
Walsh CJ, Batt J, Herridge MS, Mathur S, Bader GD, Hu P, Dos Santos CC
Determinants of downloads and citations for articles published in intensive care medicine.
Intensive Care Med Exp. 2015 Dec;3(Suppl 1):A863
Timsit JF, Citerio G, Lavilloniere M, Perner A, Smith M, Ruckly S, Bassetti M, Bakker J, Benoit D, Curtis JR, Doig G, Herridge M, Jaber S, Papazian L, Peters M, Singer P, Soares M, Torres A, Viellard-Baron A, Azoulay E
Outcome of Manuscripts Rejected From Intensive Care Medicine: An In Silico Study.
Intensive Care Med Exp. 2015 Dec;3(Suppl 1):A23
Citerio G, Marzorati C, Timsit JF, Perner A, Bakker J, Bassetti M, Benoit D, Curtis JR, Doig GS, Herridge M, Jaber S, Papazian L, Peters MJ, Singer P, Smith M, Soares M, Torres A, Vieillard-Baron A, Azoulay E
Focus on veno-venous ECMO in adults with severe ARDS.
Intensive Care Med. 2016 Jun 7;
Papazian L, Herridge M, Combes A
One-Year Outcomes in Caregivers of Critically Ill Patients.
N Engl J Med. 2016 May 12;374(19):1831-41
Cameron JI, Chu LM, Matte A, Tomlinson G, Chan L, Thomas C, Friedrich JO, Mehta S, Lamontagne F, Levasseur M, Ferguson ND, Adhikari NK, Rudkowski JC, Meggison H, Skrobik Y, Flannery J, Bayley M, Batt J, dos Santos C, Abbey SE, Tan A, Lo V, Mathur S,...
CYCLE pilot: a protocol for a pilot randomised study of early cycle ergometry versus routine physiotherapy in mechanically ventilated patients.
BMJ Open. 2016;6(4):e011659
Kho ME, Molloy AJ, Clarke F, Herridge MS, Koo KK, Rudkowski J, Seely AJ, Pellizzari JR, Tarride JE, Mourtzakis M, Karachi T, Cook DJ, Canadian Critical Care Trials Group

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Scientist, Toronto General Research Institute (TGRI)

Scientist, Division of Experimental Therapeutics - Respiratory & Critical Care, Toronto General Research Institute (TGRI)
Clinician Scientist, Co-Principal Investigator, Program in Outcomes and Rehabilitation After Critical Illness
Professor, Department Medicine, University of Toronto