Marcelo Cypel, MD, MSc, FRCSC

Dr. Cypel's research interests include lung perfusion and transplantation, gene and cell therapy to repair injured organs, and lung cancer. He has developed a successful strategy for ex vivo normothermic preservation of donor lungs (EVLP) enabling the expansion of the donor lung pool worldwide. This platform serves as a foundation for research in preservation and regenerative repair of donor lungs ex vivo, among them gene, drug and light therapies. Specifically, an innovation led by Dr. Cypel is the use of light-based therapies to inactivate Hepatitis C Virus from donor organs. This will have an impact bringing a large number of donor organs not previously available.

Dr. Cypel is a leader in basic and clinical research involving donation after cardiac death (DCD). He had a major role in implementing a DCD clinical protocol in Canada and standardized operating procedures in his lab which allow the group to test different strategies that minimize ischemic time injury.

In thoracic oncology, Dr. Cypel's research is focused on minimally invasive thoracic surgery and the use of in vivo lung perfusion model, a local delivery technique for the treatment of pulmonary metastases. Other current and future research lines include: 1) to study a lung-protective compound that prevents vascular leak during EVLP to improve post-transplantation graft function; 2) to investigate novel oxygen carriers for lung preservation in the transplant scenario; 3) to test a novel bioengineered nanofilm on the luminal surface of blood vessels of the lungs in order to prevent or delay graft rejection; 4) to explore the effects of fusion toxin proteins and monoclonal antibodies that specifically target and inactivate viral infections during EVLP; 5) to treat donor lungs during EVLP with enzymes (glycosidases) that remove blood type A/B antigen therefore lungs will become suitable for ABO incompatible transplant.

Dr. Cypel's main clinical interests include minimally invasive thoracic surgery for lung cancer, treatment of pulmonary metastases, artificial lung devices and lung transplantation.

Am J Transplant. 2019 Mar 19;:
Watanabe Y, Galasso M, Watanabe T, Ali A, Qaqish R, Nakajima D, Taniguchi Y, Pipkin M, Caldarone L, Chen M, Kanou T, Summers C, Ramadan K, Zhang Y, Chan H, Waddell TK, Liu M, Keshavjee S, Del Sorbo L, Cypel M
J Thorac Dis. 2019 Jan;11(1):30-34
Ramadan K, Del Sorbo L, Cypel M
Intensive Care Med. 2019 Feb 25;:
Cypel M, Neyrinck A, Machuca TN
Cancer Immunol Immunother. 2019 Feb 11;:
Nguyen LT, Saibil SD, Sotov V, Le MX, Khoja L, Ghazarian D, Bonilla L, Majeed H, Hogg D, Joshua AM, Crump M, Franke N, Spreafico A, Hansen A, Al-Habeeb A, Leong W, Easson A, Reedijk M, Goldstein DP, McCready D, Yasufuku K, Waddell T, Cypel M, Pierre A,...
Radiology. 2019 Feb 05;:181674
Rodrigues JCL, Pierre AF, Hanneman K, Cabanero M, Kavanagh J, Waddell TK, Chung TB, Pakkal M, Keshavjee S, Cypel M, Yasufuku K, Nguyen ET
Nat Commun. 2019 Jan 29;10(1):481
Galasso M, Feld JJ, Watanabe Y, Pipkin M, Summers C, Ali A, Qaqish R, Chen M, Ribeiro RVP, Ramadan K, Pires L, Bagnato VS, Kurachi C, Cherepanov V, Moonen G, Gazzalle A, Waddell TK, Liu M, Keshavjee S, Wilson BC, Humar A, Cypel M
Eur Respir J. 2019 Jan 17;:
Caldarone L, Mariscal A, Sage A, Khan M, Juvet S, Martinu T, Zamel R, Cypel M, Liu M, Palaniyar N, Keshavjee S
J Cardiothorac Vasc Anesth. 2018 Oct 10;:
Moreno Garijo J, Cypel M, McRae K, Machuca T, Cunningham V, Slinger P
Support Care Cancer. 2018 Nov 14;:
Hirpara DH, Kidane B, Rogalla P, Cypel M, de Perrot M, Keshavjee S, Pierre A, Waddell T, Yasufuku K, Darling GE
J Thorac Cardiovasc Surg. 2018 Oct 06;:
Wang Y, Yeung JC, Hanna WC, Allison F, Paul NS, Waddell TK, Cypel M, de Perrot ME, Yasufuku K, Keshavjee S, Pierre AF, Darling GE

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Surgical Director, UHN Transplant Program
Surgical Director, UHN ECLS Program
Canada Research Chair in Lung Transplantation
Thoracic Surgeon, University Health Network
Associate Professor of Surgery, University of Toronto