Marcelo Cypel, MD, MSc, FRCSC

Dr. Cypel's research interests include lung perfusion and transplantation, gene and cell therapy to repair injured organs, and lung cancer. He has developed a successful strategy for ex vivo normothermic preservation of donor lungs (EVLP) enabling the expansion of the donor lung pool worldwide. This platform serves as a foundation for research in preservation and regenerative repair of donor lungs ex vivo, among them gene, drug and light therapies. Specifically, an innovation led by Dr. Cypel is the use of light-based therapies to inactivate Hepatitis C Virus from donor organs. This will have an impact bringing a large number of donor organs not previously available.

Dr. Cypel is a leader in basic and clinical research involving donation after cardiac death (DCD). He had a major role in implementing a DCD clinical protocol in Canada and standardized operating procedures in his lab which allow the group to test different strategies that minimize ischemic time injury.

In thoracic oncology, Dr. Cypel's research is focused on minimally invasive thoracic surgery and the use of in vivo lung perfusion model, a local delivery technique for the treatment of pulmonary metastases. Other current and future research lines include: 1) to study a lung-protective compound that prevents vascular leak during EVLP to improve post-transplantation graft function; 2) to investigate novel oxygen carriers for lung preservation in the transplant scenario; 3) to test a novel bioengineered nanofilm on the luminal surface of blood vessels of the lungs in order to prevent or delay graft rejection; 4) to explore the effects of fusion toxin proteins and monoclonal antibodies that specifically target and inactivate viral infections during EVLP; 5) to treat donor lungs during EVLP with enzymes (glycosidases) that remove blood type A/B antigen therefore lungs will become suitable for ABO incompatible transplant.

Dr. Cypel's main clinical interests include minimally invasive thoracic surgery for lung cancer, treatment of pulmonary metastases, artificial lung devices and lung transplantation.

Lancet Respir Med. 2019 Oct 09;:
Cypel M, Feld JJ, Galasso M, Pinto Ribeiro RV, Marks N, Kuczynski M, Kumar D, Bahinskaya I, Bagnato VS, Kurachi C, Slutsky AS, Yeung JC, Donahoe L, de Perrot M, Yasufuku K, Pierre A, Binnie M, Chaparro C, Martinu T, Chen M, Tikkanen J, Chow CW, Sidhu A...
J Thorac Cardiovasc Surg. 2019 Sep 09;:
Cypel M, Yeung JC, Donahoe L, Chen M, Zamel R, Hoetzenecker K, Yasufuku K, de Perrot M, Pierre AF, Waddell TK, Keshavjee S
JAMA Surg. 2019 Oct 09;:
Divithotawela C, Cypel M, Martinu T, Singer LG, Binnie M, Chow CW, Chaparro C, Waddell TK, de Perrot M, Pierre A, Yasufuku K, Yeung JC, Donahoe L, Keshavjee S, Tikkanen JM
Ann Thorac Surg. 2019 Oct 03;:
Dos Santos PR, Yeung J, Andrade B, Reeb J, Wada H, Keshavjee S, Cypel M
J Heart Lung Transplant. 2019 Sep 10;:
Heliövaara E, Husain S, Martinu T, Singer LG, Cypel M, Humar A, Keshavjee S, Tikkanen J
J Heart Lung Transplant. 2019 Jul 26;:
Nakajima D, Watanabe Y, Ohsumi A, Pipkin M, Chen M, Mordant P, Kanou T, Saito T, Lam R, Coutinho R, Caldarone L, Juvet S, Martinu T, Iyer RK, Davies JE, Hwang DM, Waddell TK, Cypel M, Liu M, Keshavjee S
J Thorac Cardiovasc Surg. 2019 Jul 02;:
Hoetzenecker K, Cypel M
J Thorac Cardiovasc Surg. 2019 Apr 23;:
Galasso M, Vanderlaan RD, Solomon M, Caldarone C, Keshavjee S, Cypel M, de Perrot M
Curr Opin Organ Transplant. 2019 Jun;24(3):297-304
Ali A, Cypel M
Curr Opin Organ Transplant. 2019 Apr 24;:
Ali A, Cypel M

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Surgical Director, UHN Transplant Program
Surgical Director, UHN ECLS Program
Canada Research Chair in Lung Transplantation
Thoracic Surgeon, University Health Network
Associate Professor of Surgery, University of Toronto