Mansoor Husain

Mansoor Husain, BSc, FRCPC, MD

Our research aims to elucidate the molecular bases of cardiovascular diseases such as hypertension, atherosclerosis and heart failure, with a particular emphasis on identifying therapeutic targets involved in pathophysiology and a mechanism underlying the cardiovascular complications of diabetes. Our approaches encompass both cell culture-based experimental systems and tissue-specific transgenic mouse models of human cardiovascular disease.

More specifically, we study the transcriptional and post-translational regulation of cell cycle- and Ca2+-regulatory genes in vascular smooth muscle cells and the impact of molecular genetic manipulations of these pathways on both the proliferative and contractile phenotypes of vascular smooth muscle cells. We are also interested in defining the roles played by certain vasoactive hormones, enzymes and their downstream signaling pathways in inflammatory disease of the heart and circulatory system. More recently, we have begun to characterize and optimize an in vitro system for the differentiation of fully functional smooth muscle cells and cardiac myocytes from embryonic stem cells, with a view to employ these cells in disease modeling and/or regenerative therapies. We are deeply engaged in understanding the biology of the incretin hormone GLP-1 and its metabolite in the cardiovascular system. We also participate in select international and national clinical trials in this field.

Related Links

Infect Immun. 2017 Jul 03;:
Elphinstone RE, Besla R, Shikatani EA, Lu Z, Hausladen A, Davies M, Robbins CS, Husain M, Stamler JS, Kain KC
Circ Res. 2017 Jun 21;:
Cheng HS, Besla R, Li A, Chen Z, Shikatani EA, Nazari-Jahantigh M, Hammoutène A, Nguyen MA, Geoffrion M, Cai L, Khyzha N, Li T, MacParland SA, Husain M, Cybulsky MI, Boulanger CM, Temel RE, Schober A, Rayner KJ, Robbins C, Fish JE
Clin Sci (Lond). 2017 Apr 19;:
Steinbach SK, Yau TM, Ouzounian M, Abdel-Qadir H, Chandy M, Waddell T, Husain M
Am J Physiol Renal Physiol. 2017 Apr 05;:ajprenal.00043.2017
Rajasekeran H, Lytvyn Y, Bozovic A, Lovshin J, Diamandis E, Cattran D, Husain M, Perkins BA, Advani A, Reich HN, Kulasingam V, Cherney DZ
J Nucl Cardiol. 2016 Sep 23;
Abuzeid W, Iwanochko RM, Wang X, Kim SJ, Husain M, Lee DS
Diabetes. 2016 Apr 5;
Sauvé M, Hui SK, Dinh DD, Foltz WD, Momen A, Nedospasov SA, Offermanns S, Husain M, Kroetsch JT, Lidington D, Bolz SS
Arterioscler Thromb Vasc Biol. 2016 May 12;
Shikatani EA, Chandy M, Besla R, Li CC, Momen A, El-Mounayri O, Robbins CS, Husain M
Am Heart J. 2016 Apr;174:138-46
Lee DS, Husain M, Wang X, Austin PC, Iwanochko RM

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Executive Director, Ted Rogers Centre for Heart Research

Professor, Department of Medicine, University of Toronto