Mansoor Husain

Mansoor Husain, BSc, FRCPC, MD

Our research aims to elucidate the molecular bases of cardiovascular diseases such as hypertension, atherosclerosis and heart failure, with a particular emphasis on identifying therapeutic targets involved in pathophysiology and a mechanism underlying the cardiovascular complications of diabetes. Our approaches encompass both cell culture-based experimental systems and tissue-specific transgenic mouse models of human cardiovascular disease.

More specifically, we study the transcriptional and post-translational regulation of cell cycle- and Ca2+-regulatory genes in vascular smooth muscle cells and the impact of molecular genetic manipulations of these pathways on both the proliferative and contractile phenotypes of vascular smooth muscle cells. We are also interested in defining the roles played by certain vasoactive hormones, enzymes and their downstream signaling pathways in inflammatory disease of the heart and circulatory system. More recently, we have begun to characterize and optimize an in vitro system for the differentiation of fully functional smooth muscle cells and cardiac myocytes from embryonic stem cells, with a view to employ these cells in disease modeling and/or regenerative therapies. We are deeply engaged in understanding the biology of the incretin hormone GLP-1 and its metabolite in the cardiovascular system. We also participate in select international and national clinical trials in this field.
Diabetes. 2016 Apr 5;
Sauvé M, Hui SK, Dinh DD, Foltz WD, Momen A, Nedospasov SA, Offermanns S, Husain M, Kroetsch JT, Lidington D, Bolz SS
Arterioscler Thromb Vasc Biol. 2016 May 12;
Shikatani EA, Chandy M, Besla R, Li CC, Momen A, El-Mounayri O, Robbins CS, Husain M
Am Heart J. 2016 Apr;174:138-46
Lee DS, Husain M, Wang X, Austin PC, Iwanochko RM
Diabetes. 2016 Mar 2;
Cameron-Vendrig A, Reheman A, Siraj MA, Xu XR, Wang Y, Lei X, Afroze T, Shikatani E, El-Mounayri O, Noyan H, Weissleder R, Ni H, Husain M
J Cardiovasc Magn Reson. 2015;17(1):106
Thomas RM, Lim SY, Qiang B, Osherov AB, Ghugre NR, Noyan H, Qi X, Wolff R, Ladouceur-Wodzak M, Berk TA, Butany J, Husain M, Wright GA, Strauss BH
Nat Immunol. 2015 Dec 7;
Ensan S, Li A, Besla R, Degousee N, Cosme J, Roufaiel M, Shikatani EA, El-Maklizi M, Williams JW, Robins L, Li C, Lewis B, Yun TJ, Lee JS, Wieghofer P, Khattar R, Farrokhi K, Byrne J, Ouzounian M, Zavitz CC, Levy GA, Bauer CM, Libby P, Husain M,...
PLoS One. 2015;10(6):e0130658
Noyan H, El-Mounayri O, Isserlin R, Arab S, Momen A, Cheng HS, Wu J, Afroze T, Li RK, Fish JE, Bader GD, Husain M
J Am Soc Nephrol. 2015 Apr 8;
Shah A, Xia L, Masson EA, Gui C, Momen A, Shikatani EA, Husain M, Quaggin S, John R, Fantus IG

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Executive Director, Ted Rogers Centre for Heart Research

Professor, Department of Medicine, University of Toronto