Mansoor Husain, BSc, FRCPC, MD

Our research aims to elucidate the molecular bases of cardiovascular diseases such as hypertension, atherosclerosis and heart failure, with a particular emphasis on identifying therapeutic targets involved in pathophysiology and a mechanism underlying the cardiovascular complications of diabetes. Our approaches encompass both cell culture-based experimental systems and tissue-specific transgenic mouse models of human cardiovascular disease.

More specifically, we study the transcriptional and post-translational regulation of cell cycle- and Ca2+-regulatory genes in vascular smooth muscle cells and the impact of molecular genetic manipulations of these pathways on both the proliferative and contractile phenotypes of vascular smooth muscle cells. We are also interested in defining the roles played by certain vasoactive hormones, enzymes and their downstream signaling pathways in inflammatory disease of the heart and circulatory system. More recently, we have begun to characterize and optimize an in vitro system for the differentiation of fully functional smooth muscle cells and cardiac myocytes from embryonic stem cells, with a view to employ these cells in disease modeling and/or regenerative therapies. We are deeply engaged in understanding the biology of the incretin hormone GLP-1 and its metabolite in the cardiovascular system. We also participate in select international and national clinical trials in this field.
Hypertension. 2019 Jan 14;:HYPERTENSIONAHA11811828
Dingwell LS, Shikatani EA, Besla R, Levy AS, Dinh DD, Momen A, Zhang H, Afroze T, Chen MB, Chiu F, Simmons CA, Billia F, Gommerman JL, John R, Heximer S, Scholey JW, Bolz SS, Robbins CS, Husain M
Nat Immunol. 2019 Jan;20(1):29-39
Dick SA, Macklin JA, Nejat S, Momen A, Clemente-Casares X, Althagafi MG, Chen J, Kantores C, Hosseinzadeh S, Aronoff L, Wong A, Zaman R, Barbu I, Besla R, Lavine KJ, Razani B, Ginhoux F, Husain M, Cybulsky MI, Robbins CS, Epelman S
Diabetes Obes Metab. 2018 Oct 04;:
Bain SC, Mosenzon O, Arechavaleta R, Bogdański P, Comlekci A, Consoli A, Deerochanawong C, Dungan K, Faingold MC, Farkouh ME, Franco DR, Gram J, Guja C, Joshi P, Malek R, Merino-Torres JF, Nauck MA, Pedersen SD, Sheu WH, Silver RJ, Tack CJ, Tandon N,...
PLoS One. 2018;13(8):e0202778
Chandy M, Ishida M, Shikatani EA, El-Mounayri O, Park LC, Afroze T, Wang T, Marsden PA, Husain M
Eur Psychiatry. 2018 Aug 17;54:71-76
Robert P, Lanctôt KL, Agüera-Ortiz L, Aalten P, Bremond F, Defrancesco M, Hanon C, David R, Dubois B, Dujardin K, Husain M, König A, Levy R, Mantua V, Meulien D, Miller D, Moebius HJ, Rasmussen J, Robert G, Ruthirakuhan M, Stella F, Yesavage J, Zeghari...
Curr Diab Rep. 2018 Jun 09;18(7):45
Khat DZ, Husain M
Stem Cells Dev. 2018 May 02;:
Steinbach SK, Wang T, Carruthers MH, Li A, Besla R, Johnston AP, Robbins CS, Husain M
Clin Sci (Lond). 2018 Feb 27;:
Sadi AM, Afroze T, Siraj MA, Momen A, White-Dzuro C, Zarrin-Khat D, Handa S, Ban K, Kabir MG, Trivieri MG, Gros R, Backx P, Husain M
Immunity. 2017 Nov 21;47(5):974-989.e8
Clemente-Casares X, Hosseinzadeh S, Barbu I, Dick SA, Macklin JA, Wang Y, Momen A, Kantores C, Aronoff L, Farno M, Lucas TM, Avery J, Zarrin-Khat D, Elsaesser HJ, Razani B, Lavine KJ, Husain M, Brooks DG, Robbins CS, Cybulsky M, Epelman S
Am J Physiol Heart Circ Physiol. 2017 Oct 06;:ajpheart.00521.2016
Durham K, Chathely K, Mak KC, Momen A, Thomas CT, Zhao YY, MacDonald ME, Curtis JM, Husain M, Trigatti BL


Executive Director, Ted Rogers Centre for Heart Research

Professor, Department of Medicine, University of Toronto