Mamatha Bhat, MD, MSc, FRCPC

Dr. Mamatha Bhat graduated from medical school at McGill University and completed a residency in Internal Medicine and Gastroenterology at the McGill University Health Centre. Next, she completed an MSc in Experimental Medicine, as part of the Royal College Clinician Investigator Program, which was funded by a Resident Physician Health Research Career Training fellowship from the Fonds de Recherche du Quebec – Sante (FRQS). Dr. Bhat also completed a fellowship in Transplant Hepatology at Mayo Clinic in Rochester, Minnesota. She continued her research training at McGill University through a CIHR Fellowship for Health Professionals, during which she studied mRNA translation in hepatocellular carcinoma.

Dr. Bhat is currently a staff Hepatologist and clinician-scientist at UHN's Multi Organ Transplant Program and UofT's Division of Gastroenterology. She is developing a research program to enable precision medicine in hepatocellular carcinoma, non-alcoholic steatohepatitis and liver regeneration in the context of liver transplantation. Dr. Bhat’s research program employs a bench-to-bedside paradigm that connects clinical outcomes with basic research using tools from epidemiology and systems biology, including bioinformatic analysis of ‘omic datasets (e.g., transcriptomic, miRNA, methylation, intestinal microbiome). Her work will contribute to a better understanding of dysregulated gene expression, protein-protein interactions and key pathways that underpin these clinical conditions, as well as the identification of optimal therapeutic targets to treat them. Moreover, she will examine the relationship between ‘omic datasets and clinical outcomes and will validate her findings using patient samples/clinical cohorts, as well as in silico, in vitro and in vivo approaches. Dr. Bhat has assembled a multidisciplinary research team who is conducting projects at the intersection of basic science, informatics and clinical outcomes/epidemiology.

Transpl Int. 2017 Nov;30(11):1140-1149
Aravinthan AD, Barbas AS, Doyle AC, Tazari M, Sapisochin G, Cattral MS, Ghanekar A, McGilvray ID, Selzner M, Greig PD, Bhat M, Selzner N, Grant DR, Lilly LB, Renner EL
Transplant Direct. 2017 Jun;3(6):e158
Barbas AS, Goldaracena N, Dib MJ, Al-Adra DP, Aravinthan AD, Lilly LB, Renner EL, Selzner N, Bhat M, Cattral MS, Ghanekar A, McGilvray ID, Sapisochin G, Selzner M, Greig PD, Grant DR
Clin Transplant. 2017 May 10;:
Kumar D, Patil N, Husain S, Chaparro C, Bhat M, Kim SJ, Humar A
Can J Gastroenterol Hepatol. 2017;2017:4381864
Bhat M, Rollet-Kurhajec KC, Bhat A, Farag A, Deschenes M, Wong P, Ghali P, Sebastiani G
J Hepatol. 2017 Jul;67(1):92-99
Sapisochin G, Barry A, Doherty M, Fischer S, Goldaracena N, Rosales R, Russo M, Beecroft R, Ghanekar A, Bhat M, Brierley J, Greig PD, Knox JJ, Dawson LA, Grant DR
Ann Surg Oncol. 2017 Jul;24(7):1843-1851
Aravinthan AD, Bruni SG, Doyle AC, Thein HH, Goldaracena N, Issachar A, Lilly LB, Selzner N, Bhat M, Sreeharsha B, Selzner M, Ghanekar A, Cattral MS, McGilvray ID, Greig PD, Renner EL, Grant DR, Sapisochin G
Liver Transpl. 2016 Nov;22(11):1501-1508
Selzner M, Goldaracena N, Echeverri J, Kaths JM, Linares I, Selzner N, Serrick C, Marquez M, Sapisochin G, Renner EL, Bhat M, McGilvray ID, Lilly L, Greig PD, Tsien C, Cattral MS, Ghanekar A, Grant DR
J Hepatol. 2017 Feb;66(2):374-381
Bhat M, Ghali P, Dupont B, Hilzenrat R, Tazari M, Roy A, Chaudhury P, Alvarez F, Carrier M, Bilodeau M