Laura A Dawson, MD, FRCPC

The development of high-precision radiation techniques enables radiation to be investigated as a treatment for tumours previously unsuitable for radiotherapy due to proximity to critical adjacent normal tissues. An example is primary and metastatic liver cancer, a site where local therapy with surgery has the potential to cure patients, but the majority of patients are inoperable. A phase I/II study of hypofractionated high-precision radiotherapy for patients with liver cancer is open and, as part of the study, the toxicities and benefits of this treatment are being investigated. The treatment protocol involves the use of high-precision intensity modulated radiation, image guidance and breath hold radiation to minimize liver motion due to breathing.

The role of kV cone beam CT for image guidance is being investigated, as are novel methods of describing normal tissue complication probability following radiotherapy.
Eur J Cancer. 2019 Oct 11;122:42-52
Hall WA, Paulson ES, van der Heide UA, Fuller CD, Raaymakers BW, Lagendijk JJW, Li XA, Jaffray DA, Dawson LA, Erickson B, Verheij M, Harrington KJ, Sahgal A, Lee P, Parikh PJ, Bassetti MF, Robinson CG, Minsky BD, Choudhury A, Tersteeg RJHA, Schultz CJ,...
Cureus. 2019 Jun 30;11(6):e5047
Lee SL, Velec M, Munoz-Schuffenegger P, Stanescu T, Dawson L
Cancer Res. 2019 Sep 01;79(17):4326-4330
Yarchoan M, Agarwal P, Villanueva A, Rao S, Dawson LA, Llovet JM, Finn RS, Groopman JD, El-Serag HB, Monga SP, Wang XW, Karin M, Schwartz RE, Tanabe KK, Roberts LR, Gunaratne PH, Tsung A, Brown KA, Lawrence TS, Salem R, Singal AG, Kim AK, Rabiee A,...
Pract Radiat Oncol. 2019 Sep - Oct;9(5):322-332
Palta M, Godfrey D, Goodman KA, Hoffe S, Dawson LA, Dessert D, Hall WA, Herman JM, Khorana AA, Merchant N, Parekh A, Patton C, Pepek JM, Salama JK, Tuli R, Koong AC
Int J Radiat Oncol Biol Phys. 2019 Sep 01;105(1):230-231
Tsang DS, Craig T, Mishra L, Dawson LA
Clin Oncol (R Coll Radiol). 2019 Aug;31(8):560-569
Lee VHF, Seong J, Yoon SM, Wong TCL, Wang B, Zhang JL, Chiang CL, Ho PPY, Dawson LA
Comput Methods Biomech Biomed Engin. 2019 Mar 18;:1-14
Post A, Dawson L, Hoshizaki TB, Gilchrist MD, Cusimano MD
Comput Methods Biomech Biomed Engin. 2019 Mar 04;:1-13
Post A, Hoshizaki TB, Karton C, Clark JM, Dawson L, Cournoyer J, Taylor K, Oeur RA, Gilchrist MD, Cusimano MD
Pract Radiat Oncol. 2019 Feb 27;:
Dawson LA, Winter KA, Katz AW, Schell MC, Brierley J, Chen Y, Kopek N, Crane CH, Willett CG
Transplantation. 2019 Feb 18;:
Gorgen A, Rosales R, Sadler E, Beecroft R, Knox J, Dawson LA, Ghanekar A, Grant D, Greig PD, Sapisochin G

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Professor, Department of Radiation Oncology, University of Toronto
Staff Radiation Oncologist, Princess Margaret Cancer Centre