Laura A Dawson, MD, FRCPC

The development of high-precision radiation techniques enables radiation to be investigated as a treatment for tumours previously unsuitable for radiotherapy due to proximity to critical adjacent normal tissues. An example is primary and metastatic liver cancer, a site where local therapy with surgery has the potential to cure patients, but the majority of patients are inoperable. A phase I/II study of hypofractionated high-precision radiotherapy for patients with liver cancer is open and, as part of the study, the toxicities and benefits of this treatment are being investigated. The treatment protocol involves the use of high-precision intensity modulated radiation, image guidance and breath hold radiation to minimize liver motion due to breathing.

The role of kV cone beam CT for image guidance is being investigated, as are novel methods of describing normal tissue complication probability following radiotherapy.
Technol Cancer Res Treat. 2018 Jan 01;17:1533033818790217
Schaub SK, Hartvigson PE, Lock MI, Høyer M, Brunner TB, Cardenes HR, Dawson LA, Kim EY, Mayr NA, Lo SS, Apisarnthanarax S
Int J Radiat Oncol Biol Phys. 2018 Jul 15;101(4):900-909
Murray LJ, Sykes J, Brierley J, Kim JJ, Wong RKS, Ringash J, Craig T, Velec M, Lindsay P, Knox JJ, Dawson LA
Oncotarget. 2018 Apr 17;9(29):20439-20450
Hosni A, Han K, Le LW, Ringash J, Brierley J, Wong R, Dinniwell R, Brade A, Dawson LA, Cummings BJ, Krzyzanowska MK, Chen EX, Hedley D, Knox J, Easson AM, Lindsay P, Craig T, Kim J
Pract Radiat Oncol. 2018 Apr 03;:
Chen J, Murray L, Dawson LA, Velec M
Comput Methods Biomech Biomed Engin. 2018 Mar 04;:1-14
Post A, Kendall M, Cournoyer J, Karton C, Oeur RA, Dawson L, Hoshizaki TB
Int J Radiat Oncol Biol Phys. 2018 Jan 06;:
Miften M, Vinogradskiy Y, Moiseenko V, Grimm J, Yorke E, Jackson A, Tomé WA, Ten Haken RK, Ohri N, Méndez Romero A, Goodman KA, Marks LB, Kavanagh B, Dawson LA
J Surg Oncol. 2018 Feb;117(2):213-219
Loveday BPT, Knox JJ, Dawson LA, Metser U, Brade A, Horgan AM, Gallinger S, Greig PD, Moulton CA
Int J Radiat Oncol Biol Phys. 2018 Jan 06;:
Ohri N, Tomé WA, Méndez Romero A, Mifften M, Ten Haken RK, Dawson LA, Grimm J, Yorke E, Jackson A
Adv Radiat Oncol. 2016 Jan-Mar;1(1):43-50
Eccles CL, Tse RV, Hawkins MA, Lee MT, Moseley DJ, Dawson LA
Surg Oncol Clin N Am. 2017 Oct;26(4):647-666
Sim HW, Knox J, Dawson LA

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Professor, Department of Radiation Oncology, University of Toronto
Staff Radiation Oncologist, Princess Margaret Cancer Centre