- To develop a translational research program that characterizes host-parasite interactions responsible for major global health threats such as malaria and HIV; in particular to determine the molecular basis for adverse outcomes in malaria and to translate this knowledge into novel therapeutic interventions.
- To elucidate of the molecular mechanisms of antimalarial drug resistance and develop new therapies to reverse drug resistance.
- To develop molecular diagnostic and epidemiologic tools for the detection and surveillance of emerging diseases, especially those that threaten travelers, migrants, blood safety, and global health and security.
- Travel Medicine: studies examining the risk of acquisition of emerging and resurging infectious diseases, especially those relevant to travel and migration.
- Global Health and equity, knowledge sharing and education: including the transfer of appropriate technologies and the training of research scientists in the developing world, enabling and empowering them to address their own problems in a sustainable fashion.
Prognostic accuracy of sTREM-1-based algorithms in febrile adults presenting to Tanzanian outpatient clinics.
Clin Infect Dis. 2019 May 18;:
Fever in returning travellers and migrants: disease severity markers to improve triage and management.
J Travel Med. 2019 May 16;:
Perspective: L-arginine and L-citrulline Supplementation in Pregnancy: A Potential Strategy to Improve Birth Outcomes in Low-Resource Settings.
Adv Nutr. 2019 May 10;:
Systemic inflammation is associated with malaria and preterm birth in women living with HIV on antiretrovirals and co-trimoxazole.
Sci Rep. 2019 May 01;9(1):6758
Biomarkers of endothelial activation/dysfunction distinguish sub-groups of Ugandan patients with sepsis and differing mortality risks.
JCI Insight. 2019 Apr 23;5:
A Direct from Blood/Plasma Reverse Transcription-Polymerase Chain Reaction for Dengue Virus Detection in Point-of-Care Settings.
Am J Trop Med Hyg. 2019 Apr 15;:
Parasite Immunol. 2019 Jan 31;:e12614
J Travel Med. 2018 Dec 12;:
PLoS Negl Trop Dis. 2018 Nov 13;12(11):e0006951
J Travel Med. 2018 Nov 03;:
Senior Scientist, Toronto General Hospital Research Institute (TGHRI)
Canada Research Chair in Molecular Parasitology
Director, Sandra A. Rotman Laboratories, Sandra Rotman Centre for Global Health
Science Director, Tropical Disease Unit, University Health Network - Toronto General Hospital
Professor of Medicine, University of Toronto
Professor, Lab Medicine and Pathobiology, University of Toronto
Professor, Institute of Medical Sciences, University of Toronto