- To develop a translational research program that characterizes host-parasite interactions responsible for major global health threats such as malaria and HIV; in particular to determine the molecular basis for adverse outcomes in malaria and to translate this knowledge into novel therapeutic interventions.
- To elucidate of the molecular mechanisms of antimalarial drug resistance and develop new therapies to reverse drug resistance.
- To develop molecular diagnostic and epidemiologic tools for the detection and surveillance of emerging diseases, especially those that threaten travelers, migrants, blood safety, and global health and security.
- Travel Medicine: studies examining the risk of acquisition of emerging and resurging infectious diseases, especially those relevant to travel and migration.
- Global Health and equity, knowledge sharing and education: including the transfer of appropriate technologies and the training of research scientists in the developing world, enabling and empowering them to address their own problems in a sustainable fashion.
Kevin C Kain
Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria.
Malar J. 2017 Nov 14;16(1):463
Estradiol Levels Are Altered in Human Immunodeficiency Virus-Infected Pregnant Women Randomized to Efavirenz-Versus Lopinavir/Ritonavir-Based Antiretroviral Therapy.
Clin Infect Dis. 2017 Nov 10;:
Altered angiogenesis as a common mechanism underlying preterm birth, small for gestational age, and stillbirth in women living with HIV.
Am J Obstet Gynecol. 2017 Oct 12;:
Am J Epidemiol. 2017 Sep 01;186(5):603-611
Malar J. 2017 Jul 20;16(1):293
S-Nitrosoglutathione Reductase (GSNOR) Deficiency Confers Improved Survival and Neurological Outcome in Experimental Cerebral Malaria.
Infect Immun. 2017 Jul 03;:
Safety and tolerability of adjunctive rosiglitazone treatment for children with uncomplicated malaria.
Malar J. 2017 May 23;16(1):215
CMAJ. 2017 May 08;189(18):E674
Validation of two multiplex platforms to quantify circulating markers of inflammation and endothelial injury in severe infection.
PLoS One. 2017;12(4):e0175130
CMAJ. 2017 Mar 06;189(9):E334-E340
Senior Scientist, Toronto General Hospital Research Institute (TGHRI)
Canada Research Chair in Molecular Parasitology
Director, Sandra A. Rotman Laboratories, Sandra Rotman Centre for Global Health
Science Director, Tropical Disease Unit, University Health Network - Toronto General Hospital
Professor of Medicine, University of Toronto
Professor, Lab Medicine and Pathobiology, University of Toronto
Professor, Institute of Medical Sciences, University of Toronto