Joseph A Fisher

Joseph A Fisher

Over the last 15 years my laboratory has advanced the science of controlling blood gases in spontaneously breathing and ventilated subjects. We have led the way in applying this to advance the understanding of cardio-respiratory physiology and the control of brain blood flow. We have applied our technology and methods to magnetic resonance imaging (MRI) as diagnostic tests that are capable of assessing the neurological and ocular vascular component of a number neurological and ocular diseases.

Our work has translated into actual products to improve health. Examples include:
  • A small, inexpensive and easy to apply portable device that can eliminate carbon monoxide from the blood as fast as a hyperbaric chamber. The same principle applies to accelerate the elimination through the lungs of any volatile hydrocarbon including solvents, ethanol and inhaled anesthetics.
  • A small, 55 lb self-contained critical care and monitoring system currently used to provide life support to badly injured soldiers during initial resuscitation and evacuation.
  • A precise, versatile anesthetic delivery module for civilian use, but sufficiently rugged to provide anesthesia outside the strict operating room environment, such other locations inside or outside of a hospital. Whereas most anesthetic machines weigh more than 40 kg, our module weighs less than 3 kg.

I have a clinical background in anesthesiology and internal medicine. I have supervised approximately 25 graduate students; have authored or co-authored about 145 peer-reviewed publications; have 30 issued patents; and about a dozen patents pending related to the above mentioned, as well as other, areas.
J Stroke Cerebrovasc Dis. 2017 Sep 26;:
Venkatraghavan L, Poublanc J, Han JS, Sobczyk O, Rozen C, Sam K, Duffin J, Mikulis DJ, Fisher JA
Brain Behav. 2017 Sep;7(9):e00705
van Niftrik CHB, Piccirelli M, Bozinov O, Pangalu A, Fisher JA, Valavanis A, Luft AR, Weller M, Regli L, Fierstra J
J Stroke Cerebrovasc Dis. 2017 Sep 13;:
Ryan CM, Battisti-Charbonney A, Sobczyk O, Mikulis DJ, Duffin J, Fisher JA, Venkatraghavan L
Front Aging Neurosci. 2017;9:274
El-Gabalawy R, Patel R, Kilborn K, Blaney C, Hoban C, Ryner L, Funk D, Legaspi R, Fisher JA, Duffin J, Mikulis DJ, Mutch WAC
Can J Anaesth. 2017 Jul 17;:
Banik S, Fisher JA, McKetton L, Venkatraghavan L
J Nucl Med. 2017 Jun 15;:
Pelletier-Galarneau M, deKemp RA, Hunter CR, Klein R, Klein M, Ironstone J, Fisher JA, Ruddy T
Hum Brain Mapp. 2017 Apr 03;:
Fisher JA, Sobczyk O, Crawley A, Poublanc J, Dufort P, Venkatraghavan L, Sam K, Mikulis D, Duffin J
J Magn Reson Imaging. 2017 Feb 02;:
Para AE, Sam K, Poublanc J, Fisher JA, Crawley AP, Mikulis DJ
J Appl Physiol (1985). 2017 Jan 01;122(1):218-220
Bailey DM, Clark JF, Myer GD, Fisher JA, Swenson ER, Stacey BS, Smith JA, Owens TS, Bailey DM



Professor, Faculty of Medicine, University of Toronto, Canada
Chief Scientist, Thornhill Research Inc.