Jean C.Y. Wang

Jean C.Y. Wang, MD, PhD, FRCPC

Our lab is focused on understanding the biology of normal and leukemic human hematopoietic stem cells in order to develop more effective therapies for AML. Our approach involves xenotransplantation of primary acute myeloid leukemia (AML) patient samples into immune-deficient mouse recipients. This functional assay allows characterization of the relevant stem cells that sustain leukemic growth in AML. Through functional validation of leukemia cell subsets, we have identified a highly prognostic leukemia stem cell (LSC) signature and generated a deep gene expression database which we will explore to identify molecules and pathways important for LSC survival. We also use the xenotransplant model to test the efficacy of novel anti-leukemia agents, including effects against LSCs, and to develop drug response biomarkers for use as stratification tools in the clinic.

The other major area of research is an ongoing collaborative project with Jayne Danska at SickKids on the role of SIRPα in macrophage-mediated clearance of leukemia cells, and development of novel therapeutics to antagonize SIRPα in order to enhance host innate immune surveillance against leukemia.
 
PLoS One. 2017;12(2):e0172648
Smith SJ, Wang JC, Gupta VA, Dowling JJ
Can J Ophthalmol. 2016 Dec;51(6):e173-e175
Belliveau MJ, Wang JC, Nijhawan N, Latta EK, Lee JM
Nature. 2016 Dec 15;540(7633):433-437
Ng SW, Mitchell A, Kennedy JA, Chen WC, McLeod J, Ibrahimova N, Arruda A, Popescu A, Gupta V, Schimmer AD, Schuh AC, Yee KW, Bullinger L, Herold T, Görlich D, Büchner T, Hiddemann W, Berdel WE, Wörmann B, Cheok M, Preudhomme C, Dombret H, Metzeler K,...
Clin Cancer Res. 2016 Nov 17;:
Petrova PS, Viller NN, Wong M, Pang X, Lin GH, Dodge K, Chai V, Chen H, Lee V, House V, Vigo NT, Jin D, Mutukura T, Charbonneau M, Truong T, Viau S, Johnson LD, Linderoth E, Sievers EL, Maleki Vareki S, Figueredo R, Pampillo M, Koropatnick J, Trudel S,...
Leukemia. 2017 Jan;31(1):143-150
Etchin J, Berezovskaya A, Conway AS, Galinsky IA, Stone RM, Baloglu E, Senapedis W, Landesman Y, Kauffman M, Shacham S, Wang JC, Look AT
Infect Immun. 2016 Jul;84(7):2002-11
Ayi K, Lu Z, Serghides L, Ho JM, Finney C, Wang JC, Liles WC, Kain KC
Cancer Cell. 2016 Apr 11;29(4):602-6
Lechman ER, Gentner B, Ng SW, Schoof EM, van Galen P, Kennedy JA, Nucera S, Ciceri F, Kaufmann KB, Takayama N, Dobson SM, Trotman-Grant A, Krivdova G, Elzinga J, Mitchell A, Nilsson B, Hermans KG, Eppert K, Marke R, Isserlin R, Voisin V, Bader GD,...
Cancer Res. 2016 Mar 01;76(5):1214-24
Chen WC, Yuan JS, Xing Y, Mitchell A, Mbong N, Popescu AC, McLeod J, Gerhard G, Kennedy JA, Bogdanoski G, Lauriault S, Perdu S, Merkulova Y, Minden MD, Hogge DE, Guidos C, Dick JE, Wang JC
Cancer Cell. 2016 Feb 08;29(2):214-28
Lechman ER, Gentner B, Ng SW, Schoof EM, van Galen P, Kennedy JA, Nucera S, Ciceri F, Kaufmann KB, Takayama N, Dobson SM, Trotman-Grant A, Krivdova G, Elzinga J, Mitchell A, Nilsson B, Hermans KG, Eppert K, Marke R, Isserlin R, Voisin V, Bader GD,...
Oncology. 2015;89 Suppl 1:25-7
Wang JC

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