Jean C.Y. Wang

Jean C.Y. Wang, MD, PhD, FRCPC

Our lab is focused on understanding the biology of normal and leukemic human hematopoietic stem cells in order to develop more effective therapies for AML. Our approach involves xenotransplantation of primary acute myeloid leukemia (AML) patient samples into immune-deficient mouse recipients. This functional assay allows characterization of the relevant stem cells that sustain leukemic growth in AML. Through functional validation of leukemia cell subsets, we have identified a highly prognostic leukemia stem cell (LSC) signature and generated a deep gene expression database which we will explore to identify molecules and pathways important for LSC survival. We also use the xenotransplant model to test the efficacy of novel anti-leukemia agents, including effects against LSCs, and to develop drug response biomarkers for use as stratification tools in the clinic.

The other major area of research is an ongoing collaborative project with Jayne Danska at SickKids on the role of SIRPα in macrophage-mediated clearance of leukemia cells, and development of novel therapeutics to antagonize SIRPα in order to enhance host innate immune surveillance against leukemia.
Nat Commun. 2016;7:11843
Machiela MJ, Zhou W, Karlins E, Sampson JN, Freedman ND, Yang Q, Hicks B, Dagnall C, Hautman C, Jacobs KB, Abnet CC, Aldrich MC, Amos C, Amundadottir LT, Arslan AA, Beane-Freeman LE, Berndt SI, Black A, Blot WJ, Bock CH, Bracci PM, Brinton LA, Bueno-de...
Leukemia. 2016 May 23;
Etchin J, Berezovskaya A, Conway AS, Galinsky IA, Stone RM, Baloglu E, Senapedis W, Landesman Y, Kauffman M, Shacham S, Wang JC, Look AT
Infect Immun. 2016 Apr 18;
Ayi K, Lu Z, Serghides L, Ho JM, Wang JC, Liles WC, Kain KC
Cancer Res. 2016 Feb 1;
Chen WC, Yuan JS, Xing Y, Mitchell A, Mbong N, Popescu AC, McLeod J, Gerhard G, Kennedy JA, Bogdanoski G, Lauriault S, Perdu S, Merkulova Y, Minden MD, Hogge DE, Guidos C, Dick JE, Wang JC
Cancer Cell. 2016 Jan 20;
Lechman ER, Gentner B, Ng SW, Schoof EM, van Galen P, Kennedy JA, Nucera S, Ciceri F, Kaufmann KB, Takayama N, Dobson SM, Trotman-Grant A, Krivdova G, Elzinga J, Mitchell A, Nilsson B, Hermans KG, Eppert K, Marke R, Isserlin R, Voisin V, Bader GD,...
J Cataract Refract Surg. 2015 Nov;41(11):2394-402
Singh H, Wang JC, Desjardins DC, Baig K, Gagné S, Ahmed II
Oncology. 2015 Nov;89 Suppl 1:25-7
Wang JC
J Natl Cancer Inst. 2015 Dec;107(12)
Sampson JN, Wheeler WA, Yeager M, Panagiotou O, Wang Z, Berndt SI, Lan Q, Abnet CC, Amundadottir LT, Figueroa JD, Landi MT, Mirabello L, Savage SA, Taylor PR, Vivo ID, McGlynn KA, Purdue MP, Rajaraman P, Adami HO, Ahlbom A, Albanes D, Amary MF, An SJ,...
Leukemia. 2015 Jul 23;
Etchin J, Montero J, Berezovskaya A, Le BT, Kentsis A, Christie AL, Conway AS, Chen WC, Reed C, Mansour MR, Ng CE, Adamia S, Rodig SJ, Galinsky IA, Stone RM, Klebanov B, Landesman Y, Kauffman M, Shacham S, Kung AL, Wang JC, Letai A, Look TA