Hong Chang, MD, PhD, FRCPC

Multiple myeloma (MM) is a tumour resulting from clonal expansion of plasma cells and constitutes 10% of hematological malignancies. Survival times in MM are very heterogeneous amongst subgroups with different genetic profiles. The primary focus of my lab is to characterize the genomic aberrations responsible for the initiation and progression of MM, and to identify genetic risk factors that predict clinical outcome in MM patients as well as potential molecular targets for future therapy.

In preclinical studies, we investigate small molecule inhibitors that disrupt p53-MDM2 interactions and induce apoptosis in myeloma cells. We also evaluate novel small molecules that can change the conformation of a mutant p53 to a functional wild-type p53, restoring p53 function as a novel therapeutic strategy, particularly in high-risk MM patients harboring p53 deletions/mutations.
Nat Commun. 2019 Dec 13;10(1):5712
Esfahani MS, Lee LJ, Jeon YJ, Flynn RA, Stehr H, Hui AB, Ishisoko N, Kildebeck E, Newman AM, Bratman SV, Porteus MH, Chang HY, Alizadeh AA, Diehn M
Haematologica. 2019 Nov 28;:
Rastgoo N, Wu J, Liu M, Pourabdollah M, Atenafu EG, Reece D, Chen W, Chang H
Br J Haematol. 2019 Nov 23;:
Jiang G, Atenafu EG, Capo-Chichi JM, Minden MD, Chang H
Eur J Immunol. 2019 Oct;49(10):1457-1973
Cossarizza A, Chang HD, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace WW, Aghaeepour N, Akdis M, Allez M, Almeida LN, Alvisi G, Anderson G, Andrä I, Annunziato F, Anselmo A, Bacher P, Baldari CT, Bari S, Barnaba V, Barros-Martins J, Battistini L,...
Schizophr Res. 2019 Jul 29;:
Kurokawa S, Kishimoto T, Su KP, Chang JP, Chang HC, Yu X, Rodrigues-Silva N, Nielsen J, Unadkat A, Castle D, Haddad PM, Rocha D, Gadelha A, Kaliora S, Petrides G, Agid O, Tazawa Y, Takamiya A, Horigome T, Kane JM
JAMA. 2019 03 26;321(12):1176-1186
Yau TM, Pagani FD, Mancini DM, Chang HL, Lala A, Woo YJ, Acker MA, Selzman CH, Soltesz EG, Kern JA, Maltais S, Charbonneau E, Pan S, Marks ME, Moquete EG, O'Sullivan KL, Taddei-Peters WC, McGowan LK, Green C, Rose EA, Jeffries N, Parides MK, Weisel RD,...
Cancer Epidemiol Biomarkers Prev. 2019 Feb 01;:
Chang H, Yao S, Tritchler D, Hullar MA, Lampe JW, Thompson LU, McCann SE
Biomark Res. 2018;6:34
Tremblay-LeMay R, Rastgoo N, Pourabdollah M, Chang H

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Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto.