- Lineage specific differentiation of embryonic stem (ES) cells in culture
- Development of the hematopoietic, vascular, and cardiac lineages from ES cells
- Commitment of ES cells to endoderm-derived lineages
- Growth and differentiation of human embryonic stem cells
Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast.
Development. 2008 Oct;135(20):3447-58
Cancer Biol Ther. 2008 Sep;7(9):1341-7
Neuro Oncol. 2009 Apr;11(2):102-8
Serial in vivo positive contrast MRI of iron oxide-labeled embryonic stem cell-derived cardiac precursor cells in a mouse model of myocardial infarction.
Magn Reson Med. 2008 Jul;60(1):73-81
Nature. 2008 May 22;453(7194):524-8
Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood.
Cell Stem Cell. 2008 Jan 10;2(1):60-71
Nat Biotechnol. 2007 Dec;25(12):1477-82
Specification of multipotential cardiovascular progenitor cells during embryonic stem cell differentiation and embryonic development.
Trends Cardiovasc Med. 2007 Oct;17(7):240-6
Mouse embryonic stem cell-derived embryoid bodies generate progenitors that integrate long term into renal proximal tubules in vivo.
J Am Soc Nephrol. 2007 Jun;18(6):1709-20
Enhanced proapoptotic effects of tumor necrosis factor-related apoptosis-inducing ligand on temozolomide-resistant glioma cells.
J Neurosurg. 2007 Apr;106(4):646-51
Senior Scientist, Princess Margaret Cancer Centre
Director, McEwen Centre for Regenerative Medicine, University Health Network
Lead Scientist, Centre for Commercialization of Regenerative Medicine
Professor, Department of Medical Biophysics, University of Toronto