- Lineage specific differentiation of embryonic stem (ES) cells in culture
- Development of the hematopoietic, vascular, and cardiac lineages from ES cells
- Commitment of ES cells to endoderm-derived lineages
- Growth and differentiation of human embryonic stem cells
Rational bioprocess design for human pluripotent stem cell expansion and endoderm differentiation based on cellular dynamics.
Biotechnol Bioeng. 2012 Apr;109(4):853-66
Regulated expression and role of c-Myb in the cardiovascular-directed differentiation of mouse embryonic stem cells.
Circ Res. 2012 Jan 20;110(2):253-64
The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells.
Diabetologia. 2012 Feb;55(2):358-71
SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells.
Nat Biotechnol. 2011 Nov;29(11):1011-8
Pdx1 and Ngn3 overexpression enhances pancreatic differentiation of mouse ES cell-derived endoderm population.
PLoS One. 2011;6(9):e24058
Nat Cell Biol. 2011 Sep;13(9):1092-9
An endothelial cell niche induces hepatic specification through dual repression of Wnt and Notch signaling.
Stem Cells. 2011 Feb;29(2):217-28
Nat Biotechnol. 2011 Mar;29(3):267-72
Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines.
Cell Stem Cell. 2011 Feb 4;8(2):228-40
Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells.
Development. 2011 Mar;138(5):861-71
Senior Scientist, Princess Margaret Cancer Centre
Director, McEwen Centre for Regenerative Medicine, University Health Network
Lead Scientist, Centre for Commercialization of Regenerative Medicine
Professor, Department of Medical Biophysics, University of Toronto