Gary F Lewis

Gary F Lewis, MD, FRCPC

The Lewis lab has had a long interest in the mechanisms of various aspects of diabetic dyslipidemia, including postprandial lipemia, High-density Lipoprotein (HDL) lowering and hypertriglyceridemia. We have also had a long standing interest in the interaction between free fatty acids and pancreatic beta cell dysfunction. Previously, we have performed animal and human mechanistic studies but are now focusing exclusively on human studies. In 2002, working in close collaboration with Dr. Khosrow Adeli (U of T), we made the novel observation that the intestine, in addition to the liver, overproduces lipoproteins in insulin resistant states. In our current CIHR-funded work, we are determining the mechanism of intestinal and hepatic lipoprotein overproduction in insulin resistance and type 2 diabetes. We perform integrative, physiological studies in humans, attempting to determine the regulation of intestinal and hepatic lipoprotein particle production by hormones, nutrients and pharmacological agents.  
J Clin Lipidol. 2017 Mar - Apr;11(2):495-506.e3
Maraninchi M, Padilla N, Béliard S, Berthet B, Nogueira JP, Dupont-Roussel J, Mancini J, Bégu-Le Corroller A, Dubois N, Grangeot R, Mattei C, Monclar M, Calabrese A, Guérin C, Desmarchelier C, Nicolay A, Xiao C, Borel P, Lewis GF, Valéro R
Methods Inf Med. 2016 Sep 14;55(5)
Wu HT, Lewis GF, Davila MI, Daubechies I, Porges SW
Cell Rep. 2016 Jun 29;
Revelo XS, Ghazarian M, Chng MH, Luck H, Kim JH, Zeng K, Shi SY, Tsai S, Lei H, Kenkel J, Liu CL, Tangsombatvisit S, Tsui H, Sima C, Xiao C, Shen L, Li X, Jin T, Lewis GF, Woo M, Utz PJ, Glogauer M, Engleman E, Winer S, Winer DA
J Hepatol. 2016 Jun 13;
van Zutphen T, Ciapaite J, Bloks VW, Ackereley C, Gerding A, Jurdzinski A, Allgayer de Moraes R, Zhang L, Wolters JC, Bischoff R, Wanders RJ, Houten SM, Bronte-Tinkew D, Shatseva T, Lewis GF, Groen AK, Reijngoud DJ, Bakker BM, Jonker JW, Kim PK,...
Arterioscler Thromb Vasc Biol. 2016 May 5;
Xiao C, Dash S, Morgantini C, Lewis GF
Adv Nutr. 2016 Mar;7(2):364-74
Jacome-Sosa M, Parks EJ, Bruno RS, Tasali E, Lewis GF, Schneeman BO, Rains TM
Curr Opin Lipidol. 2015 Nov 30;
Dash S, Xiao C, Lewis GF
Can J Diabetes. 2015 Oct 8;
Goyal S, Morita P, Lewis GF, Yu C, Seto E, Cafazzo JA



Director, Banting and Best Diabetes Centre, University of Toronto
Director, Division of Endocrinology and Metabolism, University of Toronto
Professor, Departments of Medicine and Physiology, University of Toronto