Gary F Lewis, MD, FRCPC

The Lewis lab has had a long interest in the mechanisms of various aspects of diabetic dyslipidemia, including postprandial lipemia, High-density Lipoprotein (HDL) lowering and hypertriglyceridemia. We have also had a long standing interest in the interaction between free fatty acids and pancreatic beta cell dysfunction. Previously, we have performed animal and human mechanistic studies but are now focusing exclusively on human studies. In 2002, working in close collaboration with Dr. Khosrow Adeli (U of T), we made the novel observation that the intestine, in addition to the liver, overproduces lipoproteins in insulin resistant states. In our current CIHR-funded work, we are determining the mechanism of intestinal and hepatic lipoprotein overproduction in insulin resistance and type 2 diabetes. We perform integrative, physiological studies in humans, attempting to determine the regulation of intestinal and hepatic lipoprotein particle production by hormones, nutrients and pharmacological agents.  
 
Diabetes Obes Metab. 2018 Mar 14;:
Xiao C, Dash S, Stahel P, Lewis GF
Trends Endocrinol Metab. 2018 Jan 03;:
Xiao C, Stahel P, Carreiro AL, Buhman KK, Lewis GF
Can J Diabetes. 2017 Dec;41(6):571-575
MacCallum L, Lewis GF
Curr Opin Lipidol. 2017 Nov 11;:
Stahel P, Xiao C, Lewis GF
Arterioscler Thromb Vasc Biol. 2017 Jul 27;:
Xiao C, Dash S, Stahel P, Lewis GF
Ann Intern Med. 2017 Jul 25;:
Stahel P, Xiao C, Hegele RA, Lewis GF
Diabetologia. 2017 Jul 20;:
Ivovic A, Oprescu AI, Koulajian K, Mori Y, Eversley JA, Zhang L, Nino-Fong R, Lewis GF, Donath MY, Karin M, Wheeler MB, Ehses J, Volchuk A, Chan CB, Giacca A
J Clin Lipidol. 2017 Mar - Apr;11(2):495-506.e3
Maraninchi M, Padilla N, Béliard S, Berthet B, Nogueira JP, Dupont-Roussel J, Mancini J, Bégu-Le Corroller A, Dubois N, Grangeot R, Mattei C, Monclar M, Calabrese A, Guérin C, Desmarchelier C, Nicolay A, Xiao C, Borel P, Lewis GF, Valéro R

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Director, Banting and Best Diabetes Centre, University of Toronto
Director, Division of Endocrinology and Metabolism, University of Toronto
Professor, Departments of Medicine and Physiology, University of Toronto