The Lewis lab has had a long interest in the mechanisms of various aspects of diabetic dyslipidemia, including postprandial lipemia, High-density Lipoprotein (HDL) lowering and hypertriglyceridemia. We have also had a long standing interest in the interaction between free fatty acids and pancreatic beta cell dysfunction. Previously, we have performed animal and human mechanistic studies but are now focusing exclusively on human studies. In 2002, working in close collaboration with Dr. Khosrow Adeli (U of T), we made the novel observation that the intestine, in addition to the liver, overproduces lipoproteins in insulin resistant states. In our current CIHR-funded work, we are determining the mechanism of intestinal and hepatic lipoprotein overproduction in insulin resistance and type 2 diabetes. We perform integrative, physiological studies in humans, attempting to determine the regulation of intestinal and hepatic lipoprotein particle production by hormones, nutrients and pharmacological agents.
Gary F Lewis
Cell Rep. 2016 Jun 29;
Pharmacological Targeting of the Atherogenic Dyslipidemia Complex: The Next Frontier in CVD Prevention Beyond Lowering LDL Cholesterol.
Diabetes. 2016 Jul;65(7):1767-78
Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction.
J Hepatol. 2016 Jun 13;
Arterioscler Thromb Vasc Biol. 2016 May 5;
Postprandial Metabolism of Macronutrients and Cardiometabolic Risk: Recent Developments, Emerging Concepts, and Future Directions.
Adv Nutr. 2016 Mar;7(2):364-74
Curr Opin Lipidol. 2015 Nov 30;
The Systematic Design of a Behavioural Mobile Health Application for the Self-Management of Type 2 Diabetes.
Can J Diabetes. 2015 Oct 8;
A low protein diet combined with low-dose endotoxin leads to changes in glucose homeostasis in weanling rats.
Am J Physiol Endocrinol Metab. 2015 Jul 7;:ajpendo.00090.2015
Gut Peptides Are Novel Regulators of Intestinal Lipoprotein Secretion: Experimental and Pharmacological Manipulation of Lipoprotein Metabolism.
Diabetes. 2015 Jul;64(7):2310-8
J Clin Endocrinol Metab. 2015 May 28;:jc20151371
Senior Scientist, Toronto General Research Institute (TGRI)
Director, Banting and Best Diabetes Centre, University of Toronto
Director, Division of Endocrinology and Metabolism, University of Toronto
Professor, Departments of Medicine and Physiology, University of Toronto