The Lewis lab has had a long interest in the mechanisms of various aspects of diabetic dyslipidemia, including postprandial lipemia, High-density Lipoprotein (HDL) lowering and hypertriglyceridemia. We have also had a long standing interest in the interaction between free fatty acids and pancreatic beta cell dysfunction. Previously, we have performed animal and human mechanistic studies but are now focusing exclusively on human studies. In 2002, working in close collaboration with Dr. Khosrow Adeli (U of T), we made the novel observation that the intestine, in addition to the liver, overproduces lipoproteins in insulin resistant states. In our current CIHR-funded work, we are determining the mechanism of intestinal and hepatic lipoprotein overproduction in insulin resistance and type 2 diabetes. We perform integrative, physiological studies in humans, attempting to determine the regulation of intestinal and hepatic lipoprotein particle production by hormones, nutrients and pharmacological agents.
Gary F Lewis
Arterioscler Thromb Vasc Biol. 2017 Jul 27;:
Ann Intern Med. 2017 Jul 25;:
Evaluation of the specific effects of intranasal glucagon on circulating glucose and lipid concentrations in healthy males during a pancreatic clamp.
Diabetes Obes Metab. 2017 Jul 20;:
Diabetologia. 2017 Jul 20;:
Impact of bariatric surgery on apolipoprotein C-III levels and lipoprotein distribution in obese human subjects.
J Clin Lipidol. 2017 Mar - Apr;11(2):495-506.e3
JAMA Cardiol. 2017 Apr 05;:
Optimizing Estimates of Instantaneous Heart Rate from Pulse Wave Signals with the Synchrosqueezing Transform.
Methods Inf Med. 2016 Sep 14;55(5)
Cell Rep. 2016 Jun 29;
Pharmacological Targeting of the Atherogenic Dyslipidemia Complex: The Next Frontier in CVD Prevention Beyond Lowering LDL Cholesterol.
Diabetes. 2016 Jul;65(7):1767-78
Senior Scientist, Toronto General Hospital Research Institute (TGHRI)
Director, Banting and Best Diabetes Centre, University of Toronto
Director, Division of Endocrinology and Metabolism, University of Toronto
Professor, Departments of Medicine and Physiology, University of Toronto