Oscillations and dynamic behaviours produced by neuronal circuits are being examined in the context of several neurological diseases today. Indeed, abnormalities in brain circuits and their activities are recognized as a place to focus in untangling brain disorders.  Moreover, it is clear that cellular aspects of circuits need to be included in these examinations as specific cell types have been associated with network dysfunction and neurological disease. Computational models of neurological disease are being developed and these network models necessarily become large and complex when cellular aspects are included. A mechanistic understanding, as can be brought about by mathematical modeling and analyses, is needed. A major challenge is thus how best to bring together experimental, computational and theoretical studies to advance our understanding. 
This is the essence of my research program.

The work in my lab involves: (i) establishing intimate links with experimental studies to allow mathematical models with a neurological and pathophysiological functional basis to be developed, and (ii) simulating and analyzing developed mathematical models to enable insights and predictions to emerge. At present, we have a strong focus on the hippocampus, with a specialization on inhibitory GABAergic cells, and in the context of several physiologically relevant population activity outputs. This is being expanded to include the cortex. Inhibitory cells and networks have been found to play critical roles in learning and memory as well as in pathological conditions such as epilepsy, Alzheimer’s disease and schizophrenia. Our work is highly inter-disciplinary and collaborative by nature. 

Related Links

Ann N Y Acad Sci. 1998 Nov 16;860:266-80
Mulloney B, Skinner FK, Namba H, Hall WM
Curr Opin Neurobiol. 1998 Dec;8(6):725-32
Skinner FK, Mulloney B
J Neurosci. 1998 Nov 15;18(22):9256-68
Zhang Y, Perez Velazquez JL, Tian GF, Wu CP, Skinner FK, Carlen PL, Zhang L
J Comput Neurosci. 1997 Apr;4(2):151-60
Skinner FK, Kopell N, Mulloney B
J Neurophysiol. 1996 Aug;76(2):867-83
Sharp AA, Skinner FK, Marder E
J Comput Neurosci. 1994 Jun;1(1-2):69-87
Skinner FK, Kopell N, Marder E
Biophys J. 1993 Aug;65(2):618-29
Skinner FK, Ward CA, Bardakjian BL
Biophys Chem. 1993 Jan;45(3):253-72
Skinner FK, Ward CA, Bardakjian BL
Biol Cybern. 1993;69(5-6):375-83
Skinner FK, Turrigiano GG, Marder E



Professor, Division of Neurology, Department of Medicine, University of Toronto
Professor, Department of Physiology, University of Toronto