Our lab is focused on several aspects of translational molecular oncology, including the development of biomarkers for head and neck cancers, high throughput screens to identify novel anti-cancer therapeutics and stem cell regenerative therapy. Using DNA, RNA and protein extracted from diagnostic human cancer samples, we are in the process of conducting multi-omic global expression analyses. Preliminary data are very promising, and in addition to identifying multi-dimensional predictive/prognostic signatures for improving cancer patient management, we are also studying their related pathways and biological functions in preclinical models of human cancers. Automated robotic screens are being used to identify corresponding novel anti-cancer compounds, and characterization of these potential new therapeutics is underway. Finally, we are also interested in understanding how adipose derived stem cells may aid in tissue regeneration after treatment with ionizing radiation.
Nat Rev Drug Discov. 2019 Sep 23;:
Zhao X, Kwan JYY, Yip K, Liu PP, Liu FF
Clin Transl Radiat Oncol. 2019 Jul;17:32-39
Lee SL, Cabanero M, Hyrcza M, Butler M, Liu FF, Hansen A, Huang SH, Tsao MS, Song Y, Lu L, Xu W, Chepeha DB, Goldstein DP, Weinreb I, Bratman SV
J Med Imaging Radiat Sci. 2019 Jun;50(2):206-211
Loudon J, Proctor L, Wenz J, Roussos J, Chaudhry N, Moseley D, Zhang B, Yeung I, Liu FF, Wells W
JCO Clin Cancer Inform. 2017 11;1:1-8
Chhin V, Roussos J, Michaelson T, Bana M, Bezjak A, Foxcroft S, Hamilton JL, Liu FF
Int J Radiat Oncol Biol Phys. 2019 Jan 23;:
Beeler WH, Griffith KA, Jones RD, Chapman CH, Holliday EB, Lalani N, Wilson E, Bonner JA, Formenti SC, Hahn SM, Kalnicki S, Liu FF, Movsas B, Thomas CR, Jagsi R
Nat Commun. 2018 Nov 30;9(1):5116
Inoue M, Nakashima R, Enomoto M, Koike Y, Zhao X, Yip K, Huang SH, Waldron JN, Ikura M, Liu FF, Bratman SV
Cell Rep. 2018 Oct 30;25(5):1318-1331.e4
Karamboulas C, Bruce JP, Hope AJ, Meens J, Huang SH, Erdmann N, Hyatt E, Pereira K, Goldstein DP, Weinreb I, Su J, O'Sullivan B, Tiedemann R, Liu FF, Pugh TJ, Bratman SV, Xu W, Ailles L
J Biomed Opt. 2018 Oct;23(10):1-9
Demidov V, Zhao X, Demidova O, Pang HYM, Flueraru C, Liu FF, Vitkin IA

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Professor, Radiation Oncology, University of Toronto
Professor, Medical Biophysics, University of Toronto
Professor, Otolaryngology, University of Toronto
Chief, Radiation Medicine Program, Princess Margaret Cancer Centre
Chair, Radiation Oncology, University of Toronto