Our lab is focused on several aspects of translational molecular oncology, including the development of biomarkers for head and neck cancers, high throughput screens to identify novel anti-cancer therapeutics and stem cell regenerative therapy. Using DNA, RNA and protein extracted from diagnostic human cancer samples, we are in the process of conducting multi-omic global expression analyses. Preliminary data are very promising, and in addition to identifying multi-dimensional predictive/prognostic signatures for improving cancer patient management, we are also studying their related pathways and biological functions in preclinical models of human cancers. Automated robotic screens are being used to identify corresponding novel anti-cancer compounds, and characterization of these potential new therapeutics is underway. Finally, we are also interested in understanding how adipose derived stem cells may aid in tissue regeneration after treatment with ionizing radiation.
Lancet Oncol. 2017 May;18(5):e238
Comorbidity and performance status as independent prognostic factors in patients with head and neck squamous cell carcinoma.
Head Neck. 2016 May;38(5):736-42
Source Code Biol Med. 2017;12:1
JAMA Oncol. 2016 Dec 22;:
Source Code Biol Med. 2016;11:14
Quantitative phase-filtered wavelength-modulated differential photoacoustic radar tumor hypoxia imaging toward early cancer detection.
J Biophotonics. 2016 Oct 19;:
Bone morphogenetic protein 2 (BMP2) induces growth suppression and enhances chemosensitivity of human colon cancer cells.
Cancer Cell Int. 2016;16:77
Prognostic Factors From Computer-Assisted Image Analysis of an Oral Cavity Squamous Cell Carcinoma Tissue Microarray.
Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2S):E579
Patient Experience Survey of Early-Stage Breast Cancer Patients Undergoing Whole-Breast Radiation Therapy.
Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2S):E397
Magnetic Resonance Imaging for Breast Lumpectomy Cavity Delineation: Computed Tomography Comparison and Sequence Variation.
Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2S):E11
Senior Scientist, Princess Margaret Cancer Centre
Professor, Radiation Oncology, University of Toronto
Professor, Medical Biophysics, University of Toronto
Professor, Otolaryngology, University of Toronto
Chief, Radiation Medicine Program, Princess Margaret Cancer Centre
Chair, Radiation Oncology, University of Toronto