Our lab is focused on several aspects of translational molecular oncology, including the development of biomarkers for head and neck cancers, high throughput screens to identify novel anti-cancer therapeutics and stem cell regenerative therapy. Using DNA, RNA and protein extracted from diagnostic human cancer samples, we are in the process of conducting multi-omic global expression analyses. Preliminary data are very promising, and in addition to identifying multi-dimensional predictive/prognostic signatures for improving cancer patient management, we are also studying their related pathways and biological functions in preclinical models of human cancers. Automated robotic screens are being used to identify corresponding novel anti-cancer compounds, and characterization of these potential new therapeutics is underway. Finally, we are also interested in understanding how adipose derived stem cells may aid in tissue regeneration after treatment with ionizing radiation.
The addition of chemotherapy to radiotherapy did not reduce the rate of distant metastases in low-risk HPV-related oropharyngeal cancer in a real-world setting.
Head Neck. 2019 Feb 04;:
Gender, Professional Experiences, and Personal Characteristics of Academic Radiation Oncology Chairs: Data to Inform the Pipeline for the 21st Century.
Int J Radiat Oncol Biol Phys. 2019 Jan 23;:
Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis.
Nat Commun. 2018 Nov 30;9(1):5116
Patient-Derived Xenografts for Prognostication and Personalized Treatment for Head and Neck Squamous Cell Carcinoma.
Cell Rep. 2018 Oct 30;25(5):1318-1331.e4
Preclinical quantitative in-vivo assessment of skin tissue vascularity in radiation-induced fibrosis with optical coherence tomography.
J Biomed Opt. 2018 Oct;23(10):1-9
hsa‑miR‑24 suppresses metastasis in nasopharyngeal carcinoma by regulating the c‑Myc/epithelial‑mesenchymal transition axis.
Oncol Rep. 2018 Sep 07;:
Dysregulation of the MiR-449b target TGFBI alters the TGFβ pathway to induce cisplatin resistance in nasopharyngeal carcinoma.
Oncogenesis. 2018 May 22;7(5):40
Proteomic Analysis of Cancer-Associated Fibroblasts Reveals a Paracrine Role for MFAP5 in Human Oral Tongue Squamous Cell Carcinoma.
J Proteome Res. 2018 May 02;:
Workshop Report for Cancer Research: Defining the Shades of Gy: Utilizing the Biological Consequences of Radiotherapy in the Development of New Treatment Approaches-Meeting Viewpoint.
Cancer Res. 2018 Apr 23;:
Radiomic Biomarkers to Refine Risk Models for Distant Metastasis in HPV-related Oropharyngeal Carcinoma.
Int J Radiat Oncol Biol Phys. 2018 Feb 01;:
Senior Scientist, Princess Margaret Cancer Centre
Professor, Radiation Oncology, University of Toronto
Professor, Medical Biophysics, University of Toronto
Professor, Otolaryngology, University of Toronto
Chief, Radiation Medicine Program, Princess Margaret Cancer Centre
Chair, Radiation Oncology, University of Toronto