Our lab is focused on several aspects of translational molecular oncology, including the development of biomarkers for head and neck cancers, high throughput screens to identify novel anti-cancer therapeutics and stem cell regenerative therapy. Using DNA, RNA and protein extracted from diagnostic human cancer samples, we are in the process of conducting multi-omic global expression analyses. Preliminary data are very promising, and in addition to identifying multi-dimensional predictive/prognostic signatures for improving cancer patient management, we are also studying their related pathways and biological functions in preclinical models of human cancers. Automated robotic screens are being used to identify corresponding novel anti-cancer compounds, and characterization of these potential new therapeutics is underway. Finally, we are also interested in understanding how adipose derived stem cells may aid in tissue regeneration after treatment with ionizing radiation.
Professor, Radiation Oncology, University of Toronto
Professor, Medical Biophysics, University of Toronto
Professor, Otolaryngology, University of Toronto
Chief, Radiation Medicine Program, Princess Margaret Cancer Centre
Chair, Radiation Oncology, University of Toronto