Michael Reedijk, MD, PhD

The Notch signalling cascade is highly conserved and plays a crucial role in stem cell self-renewal, cell fate determination, epithelial cell polarity/adhesion, cell division and apoptosis in organisms from nematodes to vertebrates. Elevated expression of the Notch ligand JAG1, Notch pathway activation and expression of Notch target genes are defining features of poor-prognosis breast cancer.

Currents efforts in the laboratory are directed towards elucidating the mechanism(s) by which activated Notch signalling contributes to breast cancer development. We are using genome-wide approaches including expression array analyses, chromatin immunoprecipitation and a large-scale RNA interference- and chemical compound-based screens to identify novel regulators and targets of Notch activation in breast cancer. The value of identifying Notch regulators and targets is for their ultimate exploitation as biomarkers or therapeutic targets in Notch-activated cancers.
Cancer Immunol Immunother. 2019 Feb 11;:
Nguyen LT, Saibil SD, Sotov V, Le MX, Khoja L, Ghazarian D, Bonilla L, Majeed H, Hogg D, Joshua AM, Crump M, Franke N, Spreafico A, Hansen A, Al-Habeeb A, Leong W, Easson A, Reedijk M, Goldstein DP, McCready D, Yasufuku K, Waddell T, Cypel M, Pierre A,...
Clin Cancer Res. 2018 Jul 31;:
Toker A, Nguyen LT, Stone SC, Yang C, Katz SR, Shaw PA, Clarke BA, Ghazarian DA, Al Habeeb AS, Easson AM, Leong W, McCready D, Reedijk M, Guidos CJ, Pugh TJ, Bernardini MQ, Ohashi PS
Cancer Discov. 2017 Aug 08;:
Shen Q, Cohen B, Zheng W, Rahbar R, Martin B, Murakami K, Lamorte S, Thompson P, Berman H, Zúñiga-Pflücker JC, Ohashi PS, Reedijk M
Oncogene. 2016 Sep 5;
Izrailit J, Jaiswal A, Zheng W, Moran MF, Reedijk M
Breast Cancer Res. 2015 Dec;17(1):540
Dowling RJ, Niraula S, Chang MC, Done SJ, Ennis M, McCready DR, Leong WL, Escallon JM, Reedijk M, Goodwin PJ, Stambolic V
Gynecol Oncol. 2015 Mar 11;
Diaz-Padilla I, Wilson MK, Clarke BA, Hirte HW, Welch SA, Mackay HJ, Biagi JJ, Reedijk M, Weberpals JI, Fleming GF, Wang L, Liu G, Zhou C, Blattler C, Ivy SP, Oza AM
Cancer Immunol Res. 2014 Dec 19;
Rahbar R, Lin A, Ghazarian M, Loo Yau H, Paramathas S, Lang P, Schildknecht A, Elford A, Garcia-Batres C, Martin B, Berman HK, Leong W, McCready D, Reedijk MJ, Done SJ, Miller N, Youngson B, Suh W, Mak TW, Ohashi PS
Br J Cancer. 2013 Aug 20;109(4):943-9
Sahebjam S, Bedard PL, Castonguay V, Chen Z, Reedijk M, Liu G, Cohen B, Zhang WJ, Clarke B, Zhang T, Kamel-Reid S, Chen H, Ivy SP, Razak AR, Oza AM, Chen EX, Hirte HW, McGarrity A, Wang L, Siu LL, Hotte SJ
Invest New Drugs. 2014 Apr;32(2):243-9
Richter S, Bedard PL, Chen EX, Clarke BA, Tran B, Hotte SJ, Stathis A, Hirte HW, Razak AR, Reedijk M, Chen Z, Cohen B, Zhang WJ, Wang L, Ivy SP, Moore MJ, Oza AM, Siu LL, McWhirter E