Dennis Kim

Dennis Kim, MD, PhD

My research is aiming to develop projects of: 1) biomarker discovery using genomics in leukemias and allogeneic stem cell transplantation; and 2) clinical research in chronic myeloid leukemia and graft-versus-host disease after allogeneic stem cell transplantation.

I have also been involved in multiple exome sequencing projects in acute myleoid leukemia (AML) with normal karyotype and secondary AML progressed from antecedent hematologic malignancies, as well as chronic myeloid leukemia (CML). My future direction of genomic research is to integrate multi-omics platforms to investigate leukemia genomes, thus dissecting clonal structures in a refined way.

Not only in translational research, but also in the clinical research field, I have shown significant progress in three ways: 1) clinical database registry; 2) retrospective studies using the database; and 3) generation of prospective clinical trials in CML and in graft-versus-host disease (GVHD) and other post-transplant complications after allogeneic stem cell transplantation.  First of all, I developed a clinical database of allogeneic transplant patients (especially for GVHD and post-transplant complications) and CML patients (especially for treatment outcomes after tyrosine kinase inhibitor therapy). Secondly, I have participated in multiple ongoing clinical retrospective studies generated from the registry database. Thirdly, I am involved in  multiple clinical trials. Currently, I am the principal investigator of a pivotal Canadian tyrosine kinase inhibitor (TKI) discontinuation clinical trial and am also a chair of the correlative part of this trial, entitled "Treatment-free Remission Accomplished with Dasatinib (TRAD)". This is the first Canadian TKI discontinutation trial for the management of CML.
Clin Lymphoma Myeloma Leuk. 2017 Jul 15;:
Aghel N, Lipton JH, Atenafu EG, Kim DDH, Delgado DH
Eur J Haematol. 2017 May 27;:
Bourlon C, Lipton JH, Deotare U, Gupta V, Kim DD, Kuruvilla J, Viswabandya A, Thyagu S, Messner HA, Michelis FV
Eur J Haematol. 2017 Apr 27;:
Poch Martell M, Hamad N, Shin E, Moon JH, Sohn SK, Uhm J, Michelis FV, Viswabandya A, Lipton JH, Messner HA, Kim DDH
Biol Blood Marrow Transplant. 2017 Apr 07;:
Hamilton BK, Rybicki L, Abounader D, Adekola K, Advani A, Aldoss I, Bachanova V, Bashey A, Brown S, DeLima M, Devine S, Flowers CR, Ganguly S, Jagasia M, Kennedy VE, Kim DD, McGuirk J, Pullarkat V, Romee R, Sandhu K, Smith M, Ueda M, Viswabandya A, Vu...
Bone Marrow Transplant. 2017 Mar 06;:
Natori Y, Humar A, Lipton J, Kim DD, Ashton P, Hoschler K, Kumar D
Biol Blood Marrow Transplant. 2017 Feb 27;:
Michelis FV, Kotchetkov R, Grunwald RM, Azeem A, Atenafu EG, Lipton JH, Loach D, Gupta V, Kuruvilla J, Kim DD, Viswabandya A, Deotare U, Messner HA
Bone Marrow Transplant. 2017 Feb 20;:
Bourlon C, Alamoudi S, Kumar D, Viswabandya A, Thyagu S, Michelis FV, Kim DD, Lipton JH, Messner HA, Deotare U
Ann Hematol. 2017 Feb 18;:
Moon JH, Hamad N, Sohn SK, Uhm J, Alam N, Gupta V, Lipton JH, Messner HA, Seftel M, Kuruvilla J, Kim DD
Dis Model Mech. 2017 Jan 12;:
Kim DY, Yu J, Mui RK, Niibori R, Taufique HB, Aslam R, Semple JW, Cordes SP
Leukemia. 2017 Jan 16;:
Kim TH, Tyndel MS, Kim HJ, Ahn JS, Choi SH, Park HJ, Kim YK, Yang DH, Lee JJ, Jung SH, Kim SY, Min YH, Cheong JW, Sohn SK, Moon JH, Choi M, Lee M, Zhang Z, Kim DD