Daniel Winer

Daniel Winer, MD, FRCPC

The goal of our laboratory is to better understand how the immune system influences physiological processes and contributes to disease, with the aim of using this information to develop new translational diagnostics and therapeutics, including preventative vaccination strategies.

Inflammation and adaptive Immunity in insulin resistance and type 2 diabetes.

Our primary research focus is to elucidate immune mediated pathways governing obesity related insulin resistance. Obesity and its major complications, including insulin resistance, are a major global cause of morbidity and mortality, and have reached epidemic proportions. Evidence is mounting that a significant contributing cause of insulin resistance is chronic inflammation in visceral adipose tissue (VAT). This inflammation was initially thought to be driven solely by macrophages of the innate immune system attracted to dying adipocytes in fat. Recently, in collaboration with the Hospital for Sick Children and Stanford University, we have demonstrated that the adaptive immune system, including T cells, B cells and the antibodies they produce, play a significant and active role in regulating this process. This work has introduced a new " autoimmune" component to obesity related insulin resistance, and has led to new ways in thinking about metabolic disease. We continue to investigate immune mediated mechanisms in obesity and diabetes with the aim of translating our findings to help the many people afflicted by these diseases.
Macleans magazine
Los Angeles Times
The Globe and Mail

Cancer Res. 2017 Jun 13;:
Kenkel JA, Tseng WW, Davidson MG, Tolentino L, Choi O, Bhattacharya N, Seeley ES, Winer D, Reticker-Flynn NE, Engleman EG
Sci Immunol. 2017 Apr 21;2(10):
Ghazarian M, Revelo XS, Nøhr MK, Luck H, Zeng K, Lei H, Tsai S, Schroer SA, Park YJ, Chng MHY, Shen L, D'Angelo JA, Horton P, Chapman WC, Brockmeier D, Woo M, Engleman EG, Adeyi O, Hirano N, Jin T, Gehring AJ, Winer S, Winer DA
Nat Commun. 2017 Feb 06;8:14360
Luk CT, Shi SY, Cai EP, Sivasubramaniyam T, Krishnamurthy M, Brunt JJ, Schroer SA, Winer DA, Woo M
Endocr Pathol. 2017 Jan 24;:
Duan K, Asa SL, Winer D, Gelareh Z, Gentili F, Mete O
J Clin Invest. 2017 Jan 03;127(1):33-42
Winer DA, Winer S, Dranse HJ, Lam TK
Immunity. 2016 Aug 29;
Bhattacharya N, Yuan R, Prestwood TR, Penny HL, DiMaio MA, Reticker-Flynn NE, Krois CR, Kenkel JA, Pham TD, Carmi Y, Tolentino L, Choi O, Hulett R, Wang J, Winer DA, Napoli JL, Engleman EG
Cell Rep. 2016 Jun 29;
Revelo XS, Ghazarian M, Chng MH, Luck H, Kim JH, Zeng K, Shi SY, Tsai S, Lei H, Kenkel J, Liu CL, Tangsombatvisit S, Tsui H, Sima C, Xiao C, Shen L, Li X, Jin T, Lewis GF, Woo M, Utz PJ, Glogauer M, Engleman E, Winer S, Winer DA
Endocr Pathol. 2016 May 17;
Hyrcza MD, Winer DA, Shago M, Au K, Zadeh G, Asa SL, Mete O
Cell Metab. 2016 May 10;23(5):763-5
Revelo XS, Winer S, Winer DA
Cell Rep. 2016 Mar 8;
Tattoli I, Killackey SA, Foerster EG, Molinaro R, Maisonneuve C, Rahman MA, Winer S, Winer DA, Streutker CJ, Philpott DJ, Girardin SE

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Assistant Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto​