Christopher T M Chan

Christopher Chan graduated from the Faculty of Medicine, University of Toronto in 1995. After completing his post-graduate training in internal medicine and nephrology at the University of Toronto, he pursued further training in cardiovascular physiology. He joined the Division of Nephrology at the Toronto General Hospital, University Health Network in 2002. He is the Divisional Director of Nephrology and Professor of Medicine at the University Health Network. He also holds the R Fraser Elliott Chair in Home Dialysis.
He has contributed over 150 peer reviewed articles and has written multiple book chapters in the field of home dialysis. He has also co-led the KDIGO consensus meeting in novel approaches in blood purification and has served as chair of the cardiac committee of the Frequent Hemodialysis Network Trials. He is presently a member of the steering committee of the ACTIVE trial.
My main research themes include: (1) cardiovascular effects of nocturnal hemodialysis; (2) effects of uremia on bone marrow biology; and (3) tele-home technology.

My research activities relate to applied clinical research in the field of intensive hemodialysis. I have coordinated and led a network of research teams dedicated to examine the clinical and basic aspects of optimal dialysis delivery. Our research has led to the awareness and clinical application of nocturnal home hemodialysis for patients with refractory hypertension and ventricular dysfunction (recommended by the Canadian Society of Nephrology clinical practice guideline and Kidney Disease Improving Global Outcomes (KDIGO) consensus statement). We have investigated the impact of increased dialysis dose and frequency on anemia management and bone marrow biology. Our work has highlighted the interplay between kidney failure and bone marrow derived stem cells, which are not only required to produce red blood cells but also necessary to maintain vascular repair and regeneration. Through a fruitful collaborative network, our research team has also examined emerging e-Health technologies to assure quality and safety of remote complex care delivery. Most recently, our multi-site virtual ward proposal has received funding to test the utility of tele-home technology in vulnerable home dialysis patients during transitions of care.
JAMA Cardiol. 2018 Jan 10;:
de Boer RA, Nayor M, deFilippi CR, Enserro D, Bhambhani V, Kizer JR, Blaha MJ, Brouwers FP, Cushman M, Lima JAC, Bahrami H, van der Harst P, Wang TJ, Gansevoort RT, Fox CS, Gaggin HK, Kop WJ, Liu K, Vasan RS, Psaty BM, Lee DS, Hillege HL, Bartz TM,...
Clin J Am Soc Nephrol. 2017 Dec 14;:
McCormick BB, Chan CT, ORN Home Dialysis Research Group
Eur J Heart Fail. 2017 Dec 11;:
Bhambhani V, Kizer JR, Lima JAC, van der Harst P, Bahrami H, Nayor M, de Filippi CR, Enserro D, Blaha MJ, Cushman M, Wang TJ, Gansevoort RT, Fox CS, Gaggin HK, Kop WJ, Liu K, Vasan RS, Psaty BM, Lee DS, Brouwers FP, Hillege HL, Bartz TM, Benjamin EJ,...
Nephrology (Carlton). 2017 Dec;22 Suppl 4:3-8
Li PK, Lui SL, Ng JK, Cai GY, Chan CT, Chen HC, Cheung AK, Choi KS, Choong HL, Fan SL, Ong LM, Yu LWL, Yu XQ
Kidney Int. 2017 Aug 23;:
Tennankore KK, Na Y, Wald R, Chan CT, Perl J
Clin J Am Soc Nephrol. 2017 Aug 23;:
Trinh E, Na Y, Sood MM, Chan CT, Perl J
Can J Diabetes. 2017 Aug 16;:
Goldenberg RM, Berall M, Chan CTM, Cherney DZI, Lovshin JA, McFarlane PA, Senior PA, Verma S, Weinstein JJ
J Obstet Gynaecol Can. 2017 Jul 28;:
Wais M, Chan C
Clin J Am Soc Nephrol. 2017 Jul 24;:
Perl J, Na Y, Tennankore KK, Chan CT
Gynecol Endocrinol. 2017 Jul 02;:1-5
Arora R, Chan C, Ye XY, Greenblatt EM