Bryan Coburn

Bryan Coburn, MD, PhD, FRCPC

Dr. Bryan Coburn is a Clinician-Scientist in the Division of Infectious Diseases at the University Health Network.
The pulmonary microbiota in lung disease: The relationship between microbial community structure, age, disease stage, prognosis and severity of lung disease has been increasingly elucidated with the application of next-generation sequencing of the pulmonary microbiome. My laboratory studies the relationship between microbial community structure and disease pathogenesis in a variety of acute and chronic lung diseases to better understand microbial influences on disease pathogenesis and treatment response.

Microbial genomic diagnostics in infectious and non-infectious diseases: The human microbiome is the physiological equivalent of many other human organs or organ systems. Its role in host metabolism, immune responses, pathogen colonization resistance and treatment responsiveness are increasingly well described. We hope to develop and apply microbial genomic assays of microbiome structure and function to clinical medicine as a diagnostic test equivalent to other common tests of organ function.

Therapeutic manipulation of the microbiome: Many infectious and non-infectious diseases involve pathological perturbations of the microbiome - 'dysbiosis'. Treatments that restore a healthy microbiome have the potential to improve disease outcomes. We hope to apply the therapeutic manipulation of the human microbiome to a number of infectious and non-infectious conditions in pre-clinical and clinical models.

Related Links

J Cyst Fibros. 2018 Mar 07;:
Blanchard AC, Rooney AM, Yau Y, Zhang Y, Stapleton PJ, Horton E, Klingel M, Stanojevic S, Ratjen F, Coburn B, Waters V
Trials. 2018 Feb 17;19(1):111
Daneman N, Rishu AH, Pinto R, Aslanian P, Bagshaw SM, Carignan A, Charbonney E, Coburn B, Cook DJ, Detsky ME, Dodek P, Hall R, Kumar A, Lamontagne F, Lauzier F, Marshall JC, Martin CM, McIntyre L, Muscedere J, Reynolds S, Sligl W, Stelfox HT, Wilcox ME...
Clin Infect Dis. 2017 Aug 25;:
MacFadden DR, Daneman N, Coburn B
PLoS One. 2017;12(2):e0171218
Hughes J, Huo X, Falk L, Hurford A, Lan K, Coburn B, Morris A, Wu J
Clin Infect Dis. 2017 Feb 01;64(3):265-271
Hota SS, Sales V, Tomlinson G, Salpeter MJ, McGeer A, Coburn B, Guttman DS, Low DE, Poutanen SM
HIV Clin Trials. 2016 Jul;17(4):147-57
Kim CJ, Walmsley SL, Raboud JM, Kovacs C, Coburn B, Rousseau R, Reinhard R, Rosenes R, Kaul R
MBio. 2015;6(5):e00981-15
Diaz Caballero J, Clark ST, Coburn B, Zhang Y, Wang PW, Donaldson SL, Tullis DE, Yau YC, Waters VJ, Hwang DM, Guttman DS
Sci Rep. 2015;5:10932
Clark ST, Diaz Caballero J, Cheang M, Coburn B, Wang PW, Donaldson SL, Zhang Y, Liu M, Keshavjee S, Yau YC, Waters VJ, Elizabeth Tullis D, Guttman DS, Hwang DM
CMAJ. 2015 Aug 11;187(11):825
Coburn B, Guttman DS
Sci Rep. 2015;5:10241
Coburn B, Wang PW, Diaz Caballero J, Clark ST, Brahma V, Donaldson S, Zhang Y, Surendra A, Gong Y, Elizabeth Tullis D, Yau YC, Waters VJ, Hwang DM, Guttman DS


Assistant Professor, Laboratory Medicine and Pathobiology, University of Toronto