Brenda L Gallie

Brenda L Gallie, MD, FRCPC

My work focused on the rare cancer in children, retinoblastoma, crosses many disciplines in several institutions within the University of Toronto. My basic lab defines genomic changes that drive retinoblastoma and other cancers. I direct the clinical Retinoblastoma Program and the global hub. I lead Retinoblastoma Solutions in the clinical testing and research into mutations that initiate and cause progression of retinoblastoma. Over many years, we have contributed significantly to understanding cancer in general, by revealing the basic molecular processes that go wrong, then applying this knowledge to improve healthcare.

Concerned that our science was applied to only the lucky 8% of retinoblastoma children in developed countries, I initiated an international network to put science and optimal care within reach of the 8,000 children affected per year. The network is developing clinical trials, accessible genetic testing and rapid implementation of science at the point-of-care. The global network is rapidly improving care in Eastern Africa, India and China. For example, we have discovered a new genomic basis for some retinoblastomas, and Toronto-Beijing studies have changed care strategies by revealing high mortality when over-use of chemotherapy for severe intraocular retinoblastoma delays simple curative surgery.
Ophthalmic Genet. 2018 Jan 16;:1-4
Roelofs K, Shaikh F, Astle W, Gallie BL, Soliman SE
Ophthalmology. 2017 Nov 16;:
Zhao J, Li Q, Wu S, Jin L, Ma X, Jin M, Wang Y, Gallie B
Ophthalmic Genet. 2017 Nov 03;:1-3
Soliman SE, Racher H, Lambourne M, Matevski D, MacDonald H, Gallie B
Ophthalmology. 2017 Oct 18;:
Skalet AH, Gombos DS, Gallie BL, Kim JW, Shields CL, Marr BP, Plon SE, Chévez-Barrios P
Hum Brain Mapp. 2017 Sep 30;:
Wong NA, Rafique SA, Kelly KR, Moro SS, Gallie BL, Steeves JKE
Asia Pac J Ophthalmol (Phila). 2017 Mar-Apr;6(2):197-207
Soliman SE, Racher H, Zhang C, MacDonald H, Gallie BL
Ophthalmology. 2017 Mar 15;:
Soliman SE, VandenHoven C, MacKeen LD, Héon E, Gallie BL
Ophthalmic Genet. 2017 Mar 17;:1-3
Soliman SE, Halliday W, Shaikh F, Chan H, Hèon E, Gallie BL
Ophthalmic Genet. 2017 Jan 13;:1-3
Soliman SE, Ulster A, MacDonald H, VandenHoven C, Toi A, Hèon E, Gallie B



Professor, Molecular & Medical Genetics, University of Toronto
Professor, Medical Biophysics, University of Toronto
Professor, Ophthalmology, University of Toronto