Benjamin Haibe-Kains , PhD

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Senior Scientist, Princess Margaret Cancer Centre
https://orcid.org/0000-0002-7684-0079
Keywords: bioinformatics, cancer, genomics, pharmacogenomics, translational research, machine learning
The research performed in the Haibe-Kains Laboratory focuses on the integration of high-throughput data from various sources to simultaneously analyze multiple facets of diseases, with a particular emphasis on cancer. Dr. Haibe-Kains and his team are using publicly available genomic datasets and data generated through his collaboration to better understand the biology underlying diseases and to develop new predictive models in order to significantly improve disease management. Dr. Haibe-Kains's main contributions include several prognostic gene signatures in breast cancer, subtype classification models for ovarian and breast cancers, as well as genomic predictors of drug response in cancer cell lines.

Related Links

Lab Website
An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE).
J Immunother Cancer. 2019 Mar 13;7(1):72
Clouthier DL, Lien SC, Yang SYC, Nguyen LT, Manem VSK, Gray D, Ryczko M, Razak ARA, Lewin J, Lheureux S, Colombo I, Bedard PL, Cescon D, Spreafico A, Butler MO, Hansen AR, Jang RW, Ghai S, Weinreb I, Sotov V, Gadalla R, Noamani B, Guo M, Elston S,...
Dr.VAE: Improving drug response prediction via modeling of drug perturbation effects.
Bioinformatics. 2019 Mar 08;:
Rampášek L, Hidru D, Smirnov P, Haibe-Kains B, Goldenberg A
A Comparative Study of Cluster Detection Algorithms in Protein-Protein Interaction for Drug Target Discovery and Drug Repurposing.
Front Pharmacol. 2019;10:109
Ma J, Wang J, Ghoraie LS, Men X, Haibe-Kains B, Dai P
Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers.
J Clin Invest. 2019 Feb 12;:
Gruosso T, Gigoux M, Manem VSK, Bertos N, Zuo D, Perlitch I, Saleh SMI, Zhao H, Souleimanova M, Johnson RM, Monette A, Ramos VM, Hallett MT, Stagg J, Lapointe R, Omeroglu A, Meterissian S, Buisseret L, Van den Eynden G, Salgado R, Guiot MC, Haibe-Kains...
Network-based approach to identify principal isoforms among four cancer types.
Mol Omics. 2019 Feb 05;:
Ma J, Wang J, Ghoraie LS, Men X, Haibe-Kains B, Dai P
ONECUT2 is a driver of neuroendocrine prostate cancer.
Nat Commun. 2019 01 17;10(1):278
Guo H, Ci X, Ahmed M, Hua JT, Soares F, Lin D, Puca L, Vosoughi A, Xue H, Li E, Su P, Chen S, Nguyen T, Liang Y, Zhang Y, Xu X, Xu J, Sheahan AV, Ba-Alawi W, Zhang S, Mahamud O, Vellanki RN, Gleave M, Bristow RG, Haibe-Kains B, Poirier JT, Rudin CM,...
Whole genomes define concordance of matched primary, xenograft, and organoid models of pancreas cancer.
PLoS Comput Biol. 2019 Jan;15(1):e1006596
Gendoo DMA, Denroche RE, Zhang A, Radulovich N, Jang GH, Lemire M, Fischer S, Chadwick D, Lungu IM, Ibrahimov E, Cao PJ, Stein LD, Wilson JM, Bartlett JMS, Tsao MS, Dhani N, Hedley D, Gallinger S, Haibe-Kains B
Orchestrating a community-developed computational workshop and accompanying training materials.
F1000Res. 2018;7:1656
Davis S, Ramos M, Shepherd L, Turaga N, Geistlinger L, Morgan MT, Haibe-Kains B, Waldron L
Vulnerabilities of radiomic signature development: The need for safeguards.
Radiother Oncol. 2019 Jan;130:2-9
Welch ML, McIntosh C, Haibe-Kains B, Milosevic MF, Wee L, Dekker A, Huang SH, Purdie TG, O'Sullivan B, Aerts HJWL, Jaffray DA
The Antiarrhythmic Drug, Dronedarone, Demonstrates Cytotoxic Effects in Breast Cancer Independent of Thyroid Hormone Receptor Alpha 1 (THRα1) Antagonism.
Sci Rep. 2018 Nov 08;8(1):16562
Elliott MJ, Jerzak KJ, Cockburn JG, Safikhani Z, Gwynne WD, Hassell JA, Bane A, Silvester J, Thu KL, Haibe-Kains B, Mak TW, Cescon DW

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Senior Scientist, Princess Margaret Cancer Centre

Scientific Lead, Data Science Program, Princess Margaret Cancer Center, University Health Network
Scientific Lead, Radiomics Program of the Radiation Medicine Program (RMP), Princess Margaret Cancer Center, University Health Network
Associate Professor, Department of Medical Biophysics, University of Toronto
Adjunct Professor, Department of Computer Science, University of Toronto
Faculty Associate, Ontario Institute of Cancer Research
Faculty Affiliate, Vector Institute