Anthony E Lang

Anthony E Lang, OC, MD, FRCPC, FAAN, FCAHS, FRSC

Dr. Lang is Professor and Director of the Division of Neurology at the University of Toronto where he holds the Jack Clark Chair for Parkinson’s Disease Research. He is the Director of the Morton and Gloria Shulman Movement Disorders Center and the Edmond J. Safra Program in Parkinson’s Disease and holds the Lily Safra Chair in Movement Disorders at the Toronto Western Hospital, University Health Network. He has published over 600 peer-reviewed papers and over 100 book chapters and is one of the most highly cited investigators in the field of Movement Disorders. 

Solving the 'Parkinson Puzzle'

Our clinical research is conducted in the Morton and Gloria Shulman Movement Disorders Clinic and with important support through the Edmond J. Safra Program in Parkinsons Disease and recently the Lily Safra Chair in Movement Disorders.

We are involved in a large number of clinical research trials including pharmacologic studies evaluating a number of drugs at various stages of Parkinson's disease. Several of these trials are in collaboration with the Parkinson Study Group.

The Toronto Western Hospital Movement Disorders Program remains a world leader in the surgical management of Parkinson's disease. Recent studies include evaluation of deep brain stimulation in novel sites or for new indications.

Collaborators in the surgical arm of the program include Drs. Alfonso Fasano and Renato Munhoz in neurology and  Drs. Andres Lozano, Moji Hodaie, Suneil Kalia and Bill Hutchison in neurosurgery.

Neuropsychological and imaging evaluations of patients participating in these studies represent an important component of our collaborative research. Additional neurophysiologic studies in surgical patients as well as in other movement disorders are carried out by Dr. Robert Chen.

Clinical trials are very active in the program. Dr. Susan Fox directs a program in clinical neuropharmacology and early proof of principle studies. Dr. Connie Marras has a PhD in clinical epidemiology and is directing a program in this field as it applies to movement disorders.

We have recently developed a specialty clinic in the ataxias directed by Drs. Elizabeth Slow and Renato Munhoz. Dr. Slow also directs our Palliative Care Program for Parkinsons disease and related movement disorders.

Neuroimaging is an important component of our program and in addition to magnetic resonance imaging we are actively developing a positron-emission tomography program. Dr. Antonio Strafella directs a very active functional imaging research program using positron emission tomography and fMRI.

Molecular and cell biology and clinical genetics of movement disorders including Parkinson's disease is an areas of expanding interest in collaboration with Drs. Peter St George-Hyslop, Ekaterina Rogaeva and Lorraine Kalia.

Finally, we are actively collaborating with Dr. Jonathan Brotchie's laboratory in the study of animal models of movement disorders, particularly levodopa-induced dyskinesias.

This broad based research program is directed at attempting to solve the 'Parkinson puzzle' at many levels including attempts at understanding the cause(s), improving the accuracy of diagnosis preventing/slowing the progression and treating the later stages more effectively.
J Alzheimers Dis. 2017 Jun 27;:
Montero-Odasso M, Pieruccini-Faria F, Bartha R, Black SE, Finger E, Freedman M, Greenberg B, Grimes DA, Hegele RA, Hudson C, Kleinstiver PW, Lang AE, Masellis M, McLaughlin PM, Munoz DP, Strother S, Swartz RH, Symons S, Tartaglia MC, Zinman L, Strong...
Lancet Neurol. 2017 Jul;16(7):552-563
Boxer AL, Yu JT, Golbe LI, Litvan I, Lang AE, Höglinger GU
Lancet Neurol. 2017 Jun 16;:
Liu G, Locascio JJ, Corvol JC, Boot B, Liao Z, Page K, Franco D, Burke K, Jansen IE, Trisini-Lipsanopoulos A, Winder-Rhodes S, Tanner CM, Lang AE, Eberly S, Elbaz A, Brice A, Mangone G, Ravina B, Shoulson I, Cormier-Dequaire F, Heutink P, van Hilten JJ...
PLoS One. 2017;12(6):e0178982
Hayete B, Wuest D, Laramie J, McDonagh P, Church B, Eberly S, Lang A, Marek K, Runge K, Shoulson I, Singleton A, Tanner C, Khalil I, Verma A, Ravina B
Ann Clin Transl Neurol. 2017 Jun;4(6):360-368
Biglan KM, Oakes D, Lang AE, Hauser RA, Hodgeman K, Greco B, Lowell J, Rockhill R, Shoulson I, Venuto C, Young D, Simuni T, Parkinson Study Group STEADY‐PD III Investigators
Mov Disord. 2017 May;32(5):724-725
Marras C, Lang A, van de Warrenburg BP, Sue CM, Tabrizi SJ, Bertram L, Mercimek-Mahmutoglu S, Ebrahimi-Fakhari D, Warner TT, Durr A, Assmann B, Lohmann K, Kostic V, Klein C
Mov Disord. 2017 May 13;:
Respondek G, Kurz C, Arzberger T, Compta Y, Englund E, Ferguson LW, Gelpi E, Giese A, Irwin DJ, Meissner WG, Nilsson C, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Josephs KA, Lang AE, Mollenhauer B, Müller U, Whitwell JL, Antonini A, Bhatia KP,...
Mov Disord. 2017 May 03;:
Höglinger GU, Respondek G, Stamelou M, Kurz C, Josephs KA, Lang AE, Mollenhauer B, Müller U, Nilsson C, Whitwell JL, Arzberger T, Englund E, Gelpi E, Giese A, Irwin DJ, Meissner WG, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Antonini A, Bhatia...
PLoS One. 2017;12(4):e0173944
Butcher NJ, Merico D, Zarrei M, Ogura L, Marshall CR, Chow EWC, Lang AE, Scherer SW, Bassett AS

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Officer of the Order of Canada
Lily Safra Chair in Movement Disorders, University Health Network
Director, Edmond J. Safra Program in Parkinson's Disease, University Health Network & University of Toronto
Jack Clark Chair for Parkinson’s Disease Research, University of Toronto
Professor, Department of Medicine and Institute of Medical Science, University of Toronto