Anthony E Lang, OC, MD, FRCPC, FAAN, FCAHS, FRSC

Dr. Lang is a Professor at the University of Toronto where he holds the Jack Clark Chair for Parkinson’s Disease Research. He is the Director of the Edmond J. Safra Program in Parkinson’s Disease and the Morton and Gloria Shulman Movement Disorders Clinic and the and holds the Lily Safra Chair in Movement Disorders at the Toronto Western Hospital, University Health Network. He has published over 600 peer-reviewed papers and over 100 book chapters and is one of the most highly cited investigators in the field of Movement Disorders. 

Solving the 'Parkinson Puzzle'

Our research studies are conducted in the Edmond J. Safra Program in Parkinson’s Disease and the Morton and Gloria Shulman Movement Disorders Clinic with important support through the Lily Safra Chair in Movement Disorders.

We are involved in a large number of clinical research trials including pharmacologic studies evaluating a number of drugs at various stages of Parkinson's disease. Several of these trials are in collaboration with the Parkinson Study Group.

The Toronto Western Hospital Movement Disorders Program remains a world leader in the surgical management of Parkinson's disease including the evaluation of deep brain stimulation in novel sites or for new indications and the use of MRI-guided Focused Ultrasound.

Collaborators in the surgical arm of the program include Drs. Alfonso Fasano and Renato Munhoz in neurology and  Drs. Andres Lozano, Mojgan Hodaie, Suneil Kalia and Bill Hutchison in neurosurgery.

Neuropsychological and imaging evaluations of patients participating in these studies represent an important component of our collaborative research. Additional neurophysiologic studies in surgical patients as well as in other movement disorders are carried out by Dr. Robert Chen.

Clinical trials are very active in the program. Dr. Susan Fox directs a program in clinical neuropharmacology and early proof of principle studies. Dr. Connie Marras conducts clinical epidemiological studies including evaluating families with genetic forms of various movement disorders and assessing risk factors that could contribute to diseases such as Parkinson’s disease.  

We have recently developed a specialty clinic in the ataxias directed by Drs. Elizabeth Slow and Renato Munhoz.

Neuroimaging is an important component of our program and Dr. Antonio Strafella directs a very active functional imaging research program using positron emission tomography and functional MRI.

Molecular and cell biology and clinical genetics of movement disorders including Parkinson's disease are areas of expanding interest in collaboration with Drs. Peter St George-Hyslop, Ekaterina Rogaeva and Lorraine Kalia.

Finally, we are actively collaborating with Dr. Jonathan Brotchie's laboratory in the study of animal models of movement disorders, particularly levodopa-induced dyskinesias.

This broad-based research program is directed at attempting to solve the 'Parkinson puzzle' at many levels including attempts at understanding the cause(s), improving the accuracy of diagnosis preventing/slowing the progression and treating the later stages more effectively.

J Neurol Sci. 2018 Nov 01;396:33-35
Lizarraga KJ, Heros DO, Adams D, Lang AE, Kanner AM
J Neurol Neurosurg Psychiatry. 2018 Nov 08;:
Fearon C, Espay AJ, Lang AE, Lynch T, Martino D, Morgante F, Quinn NP, Vidailhet M, Fasano A
Mov Disord. 2018 Nov 02;:
Espay AJ, Guskey MT, Norton JC, Coate B, Vizcarra JA, Ballard C, Factor SA, Friedman JH, Lang AE, Larsen NJ, Andersson C, Fredericks D, Weintraub D
Mov Disord Clin Pract. 2018 Jan-Feb;5(1):66-74
Udow SJ, Hobson DE, Kleiner G, Masellis M, Fox SH, Lang AE, Marras C
J Neurol Neurosurg Psychiatry. 2018 Oct 25;:
Desmarais P, Rohrer JD, Nguyen QD, Herrmann N, Stuss DT, Lang AE, Boxer AL, Dickerson BC, Rosen H, van Swieten JC, Meeter LH, Borroni B, Tartaglia MC, Feldman HH, Black SE, Masellis M
Ann Neurol. 2018 Oct 24;:
Espay AJ, Morgante F, Merola A, Fasano A, Marsili L, Fox SH, Bezard E, Picconi B, Calabresi P, Lang AE
Mov Disord. 2018 Oct 19;:
Bally JF, Méneret A, Roze E, Anderson M, Grabli D, Lang AE
J Parkinsons Dis. 2018 Sep 17;:
Arora S, Visanji NP, Mestre TA, Tsanas A, AlDakheel A, Connolly BS, Gasca-Salas C, Kern DS, Jain J, Slow EJ, Faust-Socher A, Lang AE, Little MA, Marras C

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Officer of the Order of Canada
Lily Safra Chair in Movement Disorders, University Health Network
Director, Edmond J. Safra Program in Parkinson's Disease, University Health Network & University of Toronto
Jack Clark Chair for Parkinson’s Disease Research, University of Toronto
Professor, Department of Medicine and Institute of Medical Science, University of Toronto