Andy Kin On Wong, BSc, PhD

Follow Dr. Wong:

I am a medical imaging scientist and epidemiologist. Using this unique combination of skills, I study bones, muscles, joints, and fat in the aging population with particular focus on osteoarthritis, osteoporosis and the interaction of these diseases.

Osteoarthritis affects over 10% of Canadians over age 15, resulting in disability, and some necessitating joint replacement. Among those diagnosed with arthritis, osteoarthritis alone accounts for 37%, within which 29% have knee osteoarthritis. Although knee osteoarthritis is often considered a single disease, there are multiple phenotypes and each are associated with differing risk factors.

Osteoporosis is a silent thief – 1 in 4 women, and 1 in 5 men have osteoporosis but many do not know until they have fractured a bone or when screened with a bone density test. Though, even with a normal bone density scan, many still sustain fractures. More recently, we have been able to quantify bone microarchitecture in greater detail, information which may further improve fracture risk prediction.

A subset of individuals with knee osteoarthritis has weakened bones or a higher bone turnover. By applying bone imaging techniques to osteoarthritis, we could better understand the disease process in this sub-group, and could identify interventions that prevent disease progression or reverse early damage.

Our research projects are focused on:

  1. Understanding the disease process for specific knee osteoarthritis phenotypes: a) in those with knee osteoarthritis and altered bone quality or bone turnover; and b) in those with metabolism-related knee osteoarthritis
  2. Exploring treatment of knee osteoarthritis in those with impaired bone quality using antiresorptive therapies
  3. Determining imaging-based predictors of success in knee arthroscopic surgeries
  4. Innovating novel imaging techniques to discover more pain-sensitive measures
  5. Generating population-based references to enable individual-based diagnostic evaluation for knee osteoarthritis

Related Links

J Bone Miner Res. 2019 Nov 01;:
Wong AK, Chandrakumar A, Whyte R, Reitsma S, Gillick H, Pokhoy A, Papaioannou A, Adachi JD
Lancet Diabetes Endocrinol. 2019 Jan;7(1):34-43
Samelson EJ, Broe KE, Xu H, Yang L, Boyd S, Biver E, Szulc P, Adachi J, Amin S, Atkinson E, Berger C, Burt L, Chapurlat R, Chevalley T, Ferrari S, Goltzman D, Hanley DA, Hannan MT, Khosla S, Liu CT, Lorentzon M, Mellstrom D, Merle B, Nethander M,...
J Clin Densitom. 2018 Sep 22;:
Wong AKO, Szabo E, Erlandson M, Sussman MS, Duggina S, Song A, Reitsma S, Gillick H, Adachi JD, Cheung AM
BMC Geriatr. 2018 01 05;18(1):4
Gajic-Veljanoski O, Papaioannou A, Kennedy C, Ioannidis G, Berger C, Wong AKO, Rockwood K, Kirkland S, Raina P, Thabane L, Adachi JD, CaMos Research Group
J Am Med Dir Assoc. 2017 May 01;18(5):414-419
Li G, Papaioannou A, Thabane L, Levine MAH, Ioannidis G, Wong AKO, Lau A, Adachi JD
J Clin Densitom. 2017 Jan 03;:
Chan AC, Adachi JD, Papaioannou A, Wong AK


Assistant Professor of Epidemiology, Dalla Lana School of Public Health, University of Toronto
Assistant Clinical Professor (Adjunct), Department of Medicine, McMaster University