Andy Kin On Wong

Andy Kin On Wong, BSc, PhD

Follow Dr. Wong:

I am a medical imaging scientist and epidemiologist. Using this unique combination of skills, I study bones, muscles, joints, and fat in the aging population with particular focus on osteoarthritis, osteoporosis and the interaction of these diseases.

Osteoarthritis affects over 10% of Canadians over age 15, resulting in disability, and some necessitating joint replacement. Among those diagnosed with arthritis, osteoarthritis alone accounts for 37%, within which 29% have knee osteoarthritis. Although knee osteoarthritis is often considered a single disease, there are multiple phenotypes and each are associated with differing risk factors.

Osteoporosis is a silent thief – 1 in 4 women, and 1 in 5 men have osteoporosis but many do not know until they have fractured a bone or when screened with a bone density test. Though, even with a normal bone density scan, many still sustain fractures. More recently, we have been able to quantify bone microarchitecture in greater detail, information which may further improve fracture risk prediction.

A subset of individuals with knee osteoarthritis has weakened bones or a higher bone turnover. By applying bone imaging techniques to osteoarthritis, we could better understand the disease process in this sub-group, and could identify interventions that prevent disease progression or reverse early damage.

Our research projects are focused on:

  1. Understanding the disease process for specific knee osteoarthritis phenotypes: a) in those with knee osteoarthritis and altered bone quality or bone turnover; and b) in those with metabolism-related knee osteoarthritis
  2. Exploring treatment of knee osteoarthritis in those with impaired bone quality using antiresorptive therapies
  3. Determining imaging-based predictors of success in knee arthroscopic surgeries
  4. Innovating novel imaging techniques to discover more pain-sensitive measures
  5. Generating population-based references to enable individual-based diagnostic evaluation for knee osteoarthritis

Related Links

BMC Geriatr. 2018 01 05;18(1):4
Gajic-Veljanoski O, Papaioannou A, Kennedy C, Ioannidis G, Berger C, Wong AKO, Rockwood K, Kirkland S, Raina P, Thabane L, Adachi JD, CaMos Research Group
J Am Med Dir Assoc. 2017 May 01;18(5):414-419
Li G, Papaioannou A, Thabane L, Levine MAH, Ioannidis G, Wong AKO, Lau A, Adachi JD
J Clin Densitom. 2017 Jan 03;:
Chan AC, Adachi JD, Papaioannou A, Wong AK
J Clin Densitom. 2017 Apr - Jun;20(2):226-232
Erlandson MC, Wong AKO, Szabo E, Vilayphiou N, Zulliger MA, Adachi JD, Cheung AM
Bioinformatics. 2016 Aug 15;32(16):2427-34
Lee ES, Whelan FJ, Bowdish DM, Wong AK


Assistant Professor of Epidemiology, Dalla Lana School of Public Health, University of Toronto
Assistant Clinical Professor (Adjunct), Department of Medicine, McMaster University