Aaron D Schimmer, PhD, MD, FRCPC

Our lab is focused on developing novel therapeutic strategies that target leukemia and leukemia stem cells. Using chemical and genetic approaches, our laboratory investigates targeting protein synthesis and degradation pathways in the mitochondria and cytoplasm. Mechanistic studies are coupled with preclinical evaluation to understand the biology of leukemia stem cells and highlight therapeutic strategies with potential therapeutic windows. In addition to acting as biological tools, these molecules also serve as leads for potential new treatment strategies. For example, using these approaches, we have demonstrated that acute myeloid leukemia (AML) cells and stem cells have a unique reliance on mitochondrial metabolism and have heightened sensitivity to inhibitors of mitochondrial translation. We have also demonstrated increased lysosomal mass in AML cells and increased sensitivity to lysosome disruption in this disease. To rapidly identify and test new therapeutic strategies in early proof-of-principle clinical trials, the Schimmer lab has also advanced compounds directly from the lab into Phase I clinical trials.
Cell Stem Cell. 2018 Jul 05;23(1):3-4
Schimmer AD
Leukemia. 2018 Jun 08;:
Barghout SH, Patel PS, Wang X, Xu GW, Kavanagh S, Halgas O, Zarabi SF, Gronda M, Hurren R, Jeyaraju DV, MacLean N, Brennan S, Hyer ML, Berger A, Traore T, Milhollen M, Smith AC, Minden MD, Pai EF, Hakem R, Schimmer AD
J Am Dent Assoc. 2018 Mar 30;:
Watson E, Wood RE, Maxymiw WG, Schimmer AD
Leuk Res. 2018 Feb 20;68:22-28
Kavanagh S, Heath E, Hurren R, Gronda M, Barghout SH, Liyanage SU, Siriwardena TP, Claudio J, Zhang T, Sukhai M, Stockley TL, Kamel-Reid S, Rostom A, Lutynski A, Khalaf D, Rydlewski A, Chan SM, Gupta V, Maze D, Sibai H, Schuh AC, Yee K, Minden MD,...
Leuk Res. 2018 Feb 15;67:86-91
Deckert AL, Gheihman G, Nissim R, Chung C, Schimmer AD, Zimmermann C, Rodin G
Blood Adv. 2017 Sep 12;1(20):1729-1738
Spiegel JY, McNamara C, Kennedy JA, Panzarella T, Arruda A, Stockley T, Sukhai M, Thomas M, Bartoszko J, Ho J, Siddiq N, Maze D, Schimmer A, Schuh A, Sibai H, Yee K, Claudio J, Devlin R, Minden MD, Kamel-Reid S, Gupta V
Clin Microbiol Infect. 2017 Nov 11;:
So M, Mamdani M, Morris A, Lau T, Broady R, Deotare U, Grant J, Kim DDH, Schimmer AD, Schuh A, Shajari S, Steinberg M, Bell CM, Husain S
Clin Microbiol Infect. 2017 Sep 29;:
Bhimji A, Bhaskaran A, Singer LG, Kumar D, Humar A, Pavan R, Lipton J, Kuruvilla J, Schuh A, Yee K, Minden MD, Schimmer A, Rotstein C, Keshavjee S, Mazzulli T, Husain S
JCI Insight. 2017 Sep 21;2(18):
Kavanagh S, Murphy T, Law A, Yehudai D, Ho JM, Chan S, Schimmer AD
Leuk Res. 2017 Aug 25;61:39-43
Chen Y, Pourabdollah M, Atenafu EG, Tierens A, Schimmer A, Chang H

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Professor, Department of Medical Biophysics, University of Toronto
Staff Physician, Leukemia Site Group, Princess Margaret Cancer Centre