Aaron D Schimmer, PhD, MD, FRCPC

Our lab is interested in developing new therapeutic strategies for AML (acute myeloid leukemia) that effectively target leukemic stem cells. Using genetic and chemical approaches, including high throughput screens, we identify biological vulnerabilities in the AML cells and stem cells with a focus on mitochondrial and metabolic pathways. Through these efforts, we discover new biological pathways important for the growth and viability of AML and highlight new therapeutic approaches for this disease.
Haematologica. 2018 Dec 20;:
Yehudai D, Liyanage SU, Hurren R, Rizoska B, Albertella M, Gronda M, Jeyaraju DV, Wang X, Barghout SH, MacLean N, Siriwardena TP, Jitkova Y, Targett-Adams P, Schimmer AD
Support Care Cancer. 2018 Dec 08;:
Shaulov A, Rodin G, Popovic G, Caraiscos VB, Le LW, Rydall A, Schimmer AD, Zimmermann C
Nat Commun. 2018 Dec 03;9(1):5132
Bahat A, Goldman A, Zaltsman Y, Khan DH, Halperin C, Amzallag E, Krupalnik V, Mullokandov M, Silberman A, Erez A, Schimmer AD, Hanna JH, Gross A
Cancer Cell. 2018 Nov 12;34(5):695-696
Nachmias B, Schimmer AD
Chemotherapy. 2018 Oct 29;63(4):225-237
Khoury H, He R, Schimmer A, Beadle JR, Hostetler KY, Minden MD
Oncotarget. 2018 Sep 28;9(76):34198-34199
Barghout SH, Schimmer AD
Support Care Cancer. 2018 Oct 19;:
Brandwein JM, Seki JT, Atenafu EG, Rostom A, Lutynski A, Rydlewski A, Schimmer AD, Schuh AC, Gupta V, Yee KWL
Blood Adv. 2018 Oct 23;2(20):2658-2671
McNamara CJ, Panzarella T, Kennedy JA, Arruda A, Claudio JO, Daher-Reyes G, Ho J, Siddiq N, Devlin R, Tsui H, Su J, Stockley T, Sukhai M, Kanwar N, Chan S, Maze D, Schimmer A, Schuh A, Sibai H, Viswabandya A, Yee K, Minden MD, Kamel-Reid S, Gupta V
Psychooncology. 2018 Oct 12;:
Fraser B, Korenblum C, Mah K, Watt S, Malfitano C, Rydall A, Schimmer A, Zimmermann C, Rodin G
Cell Chem Biol. 2018 Aug 16;25(8):1017-1030.e9
Wong KS, Mabanglo MF, Seraphim TV, Mollica A, Mao YQ, Rizzolo K, Leung E, Moutaoufik MT, Hoell L, Phanse S, Goodreid J, Barbosa LRS, Ramos CHI, Babu M, Mennella V, Batey RA, Schimmer AD, Houry WA

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Professor, Department of Medical Biophysics, University of Toronto
Staff Physician, Leukemia Site Group, Princess Margaret Cancer Centre