Aaron D Schimmer, MD, PhD, FRCPC

Our lab is interested in developing new therapeutic strategies for AML (acute myeloid leukemia) that effectively target leukemic stem cells. Using genetic and chemical approaches, including high throughput screens, we identify biological vulnerabilities in the AML cells and stem cells with a focus on mitochondrial and metabolic pathways. Through these efforts, we discover new biological pathways important for the growth and viability of AML and highlight new therapeutic approaches for this disease.
Sci Transl Med. 2019 Oct 30;11(516):
Sharon D, Cathelin S, Mirali S, Di Trani JM, Yanofsky DJ, Keon KA, Rubinstein JL, Schimmer AD, Ketela T, Chan SM
Proteomics. 2019 Oct 16;:e1900139
Botham A, Coyaud E, Nirmalanandhan VS, Gronda M, Hurren R, Maclean N, St-Germain J, Mirali S, Laurent E, Raught B, Schimmer A
Mol Cell Oncol. 2019;6(5):e1620051
Seneviratne AK, Xu M, Schimmer AD
Blood Adv. 2019 Aug 13;3(15):2307-2311
Murphy T, Zou J, Daher-Reyes GS, Arruda A, Gupta V, McNamara CJ, Minden MD, Schimmer AD, Sibai H, Yee KWL, Korulla M, Stockley T, Kamel-Reid S, Maze D, Tierens A, Bratman SV, Schuh AC, Chan SM
Aging (Albany NY). 2019 Jun 25;11(12):3895-3897
Xu M, Seneviratne AK, Schimmer AD
J Med Chem. 2019 Jul 11;62(13):6377-6390
Tan J, Grouleff JJ, Jitkova Y, Diaz DB, Griffith EC, Shao W, Bogdanchikova AF, Poda G, Schimmer AD, Lee RE, Yudin AK
Cell Stem Cell. 2019 Jun 06;24(6):1007
Seneviratne AK, Xu M, Aristizabal Henao JJ, Fajardo VA, Hao Z, Voisin V, Xu GW, Hurren R, Kim S, MacLean N, Wang X, Gronda M, Jeyaraju D, Jitkova Y, Ketela T, Mullokandov M, Sharon D, Thomas G, Chouinard-Watkins R, Hawley JR, Schafer C, Yau HL, Khuchua...
Mol Cancer Ther. 2019 May 15;:
Dai S, Yang S, Hu X, Sun W, Tawa G, Zhu W, Schimmer AD, He C, Fang B, Zhu H, Zheng W
Cancer Cell. 2019 May 13;35(5):721-737.e9
Ishizawa J, Zarabi SF, Davis RE, Halgas O, Nii T, Jitkova Y, Zhao R, St-Germain J, Heese LE, Egan G, Ruvolo VR, Barghout SH, Nishida Y, Hurren R, Ma W, Gronda M, Link T, Wong K, Mabanglo M, Kojima K, Borthakur G, MacLean N, Ma MCJ, Leber AB, Minden MD,...
Support Care Cancer. 2019 Apr 17;:
Rodin G, Malfitano C, Rydall A, Schimmer A, Marmar CM, Mah K, Lo C, Nissim R, Zimmermann C

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Professor, Department of Medical Biophysics, University of Toronto
Staff Physician, Leukemia Site Group, Princess Margaret Cancer Centre