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Robert E W Chen, MA, BChir, MB, MSc
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Senior Scientist
Division of Brain Imaging & Behaviour Systems - Neuroscience
Toronto Western Research Institute (TWRI) |
Keywords: Parkinson's disease, human neurophysiology, motor cortex, transcranial magnetic stimulation, dystonia, plasticity, electroencephalography, deep brain stimulation
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Our laboratory is currently investigating the organization of cortical inhibitory and excitatory pathways in the human motor cortex, pathophysiology of movement disorders, the mechanisms of action of deep brain stimulation as a treatment of movement disorders and cortical plasticity following peripheral injury such as amputation or nerve and muscle transfer.
The techniques used include single pulse, paired pulse and repetitive magnetic brain stimulation; detailed analysis, computer modeling and co-registration with structural MRI images of electroencephaolgraphic (EEG) cortical rhythms, and movement-related cortical potentials.
Additional Appointments
- Professor, Division of Neurology, Department of Medicine, University of Toronto
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Pubmed Publications | | | |
Selected Publications | - Kuriakose R, Saha U, Castillo G, Udupa K, Ni Z, Gunraj C, Mazzella F, Hamani C, Lang AE, Moro E, Lozano AM, Hodaie M, Chen R. The nature and time course of cortical activation following subthalamic stimulation in Parkinson's disease. Cerebral Cortex, in press.
- Ni Z, Anastakis DJ, Gunraj C, Chen R. Reversal of cortical reorganization in human primary motor cortex following thumb reconstruction. Journal of Neurophysiology, published online November 11, 2009.
- Wagle-Shukla A, Ni Z, Gunraj CA, Bahl N, Chen R. Effects of short interval intracortical inhibition and intracortical facilitation on short interval intracortical facilitation in human primary motor cortex. Journal of Physiology 2009, 587: 5565-5678.
- Obhi SS, Matkovich S, Chen R. Changing the ''when'' and ''what'' of intended actions. Journal of Neurophysiology 2009, 102: 2755-2762.
- Udupa K, Ni Z, Gunraj C, Chen R. Interactions between short latency afferent inhibition and long interval intracortical inhibition. Experimental Brain Research 2009, 199: 177-183.
- Barr MS, Farzan F, Rusjan PM, Chen R, Fitzgerald PB, Daskalakis ZJ. Potentiation of gamma oscillatory activity through repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex. Neuropsychopharmacology 2009, 34: 2357-2367.
- Ballanger B, Lozano AM, Moro E, van Eimeren T, Hamani C, Chen R, Cilia R, Houle S, Poon YY, Lang AE and Strafella AP. Cerebral blood flow changes induced by pedunculopontine nucleus stimulation in patients with advanced Parkinson's disease: a [(15)O] H2O PET study. Human Brain Mapping 2009, 30: 3901-3909.
- Leung A, Donohue M, Xu R, Lee R, Lefaucheur JP, Khedr EM, Saitoh Y, Andri-Obadia N, Rollnik J, Wallace M, Chen R. rTMS for suppressing neuropathic pain: A Meta-Analysis. The Journal of Pain, published online May 21 2009.
- Marquez-Chin C, Popovic MR, Cameron T, Lozano AM, Chen R. Control of a neuroprosthesis for grasping using off-line classification of electrocorticographic signals: Case Study. Spinal Cord 2009, 47: 802-808.
- Nelson AJ, Hoque T, Gunraj C, Ni Z, Chen R. Bi-directional interhemispheric inhibition during unimanual sustained contractions. BMC Neuroscience 2009, 10: 31.
- Lim SY, Mason WP, Young NP, Chen R, Bower JH, McKeon A, Pittock SJ, Lang AE. Polymyoclonus, laryngospasm, and cerebellar ataxia associated with adenocarcinoma and multiple neural cation channel autoantibodies. Archives of Neurology 2009, 66: 1285-1287.
- Nelson AJ, Blake DT, Chen R. Digit-specific aberrations in different subregions of the primary somatosensory cortex in Writer's Cramp. Annals of Neurology 2009, 66: 146-154.
- Udupa K, Chen R. Measurement and modulation of brain plasticity of the motor system in humans using transcranial magnetic stimulation. Motor Control 2009, 13: 422-453.
- Chu J, Wagle-Shukla A, Gunraj C, Lang AE, Chen R. Impaired presynaptic inhibition in the motor cortex in Parkinson Disease. Neurology 2009, 72: 842-849.
- Espay AJ Beaton DE, Morgante F, Gunraj CA, Lang AE, Chen R. Impairments of speed and amplitude of movement in Parkinson's disease: a pilot study. Movement Disorders 2009, 23: 1001-1008.
- Kirton A, Gunraj C, Chen R. Neuro-cardiovascular coupling with transcranial magnetic stimulation for diagnosis of vascular compression cranial neuropathy. Canadian Journal Neurological Sciences 2009; 36:83-88.
- Farzan F, Barr M, Wong W, Chen R, Fitzgerald P, Daskalakis ZJ. Suppression of gamma oscillation in the dorsolateral prefrontal cortex following long interval cortical inhibition: a TMS-EEG Study. Neuropsychopharmacology 2009, 34: 1543-1551.
- Ni Z, Gunraj C, Nelson AJ, Yeh I-J, Castillo G, Hoque T, Chen R. Two phases of interhemispheric inhibition between motor related cortical areas and the primary motor cortex in human. Cerebral Cortex 2009, 19: 1654-1665.
- Elahi B, Elahi B, Chen R. Effect of transcranial magnetic stimulation on Parkinson motor function Systematic review of controlled clinical trials. Movement Disorders 2009, 24: 357-363.
- Liu SK, Fitzgerald PB, Daigle M, Chen R, Daskalakis ZJ. The relationship between cortical inhibition, antipsychotic treatment and the symptoms of schizophrenia. Biological Psychiatry 2009, 65: 503-509.
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Primary Office
Toronto Western Hospital
McLaughlin Pavilion
7th Floor Rm 7MCL411
399 Bathurst St.
Toronto, Ontario
Canada M5T 2S8 |
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| 416-603-5207 | (Primary) | | 416-603-5792 | (LAB) | | 416-603-5004 | (FAX) | | 416-603-5424 | (Additional) |
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| Akihiro Yugeta
| | Behzad Elahi |
| Bogdan Neagu |
| Carolyn Gunraj |
| Eric Tsang |
| Kaviraja Udupa |
| Nicolas Phielipp |
| Nina Bahl |
| Rhoda Ortiz |
| Robin Cash |
| Takashi Yoshida |
| Tasnuva Hoque |
| Utpal Saha |
| Zhen Ni |
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