• Nontuberculous mycobacteria

Study Status: active

Institute: Krembil Research Institute

Study Purpose: This study aims to learn why some people continue to have Mycobacterium avium bacteria in their lungs even while taking treatment. Researchers want to find out whether the bacteria stay the same over time or whether people are exposed to new bacteria from their environment, such as their home water supply. This study will compare bacteria collected before, during, and after treatment. It will also compare bacteria found in home water samples.

Background: Mycobacterium avium is a type of bacteria that can cause long-lasting lung infections. Treatment can take many months and may not always clear the infection. In some people, the bacteria return after treatment or remain present during treatment. Researchers think that some people may be continually exposed to the bacteria through household water sources such as showers and faucets.

Study Methods: About 40 adults receiving treatment for Mycobacterium avium lung disease will take part. Researchers will study bacteria from sputum (mucus coughed up from the lungs) and compare them over time using a detailed DNA test called whole genome sequencing. Participants will also collect samples from their showerheads and faucets at home, which will also be studied to detect Mycobacterium avium and by DNA testing if the bacteria is found. We will also ask participants to complete short surveys about their symptoms and quality of life every three months, while receiving their usual care.

Health Conditions: Lungs & Breathing conditions

For a list of Dr. Marras's publications, please visit PubMed or Scopus.

• Director Toronto Western Hospital Nontuberculous Mycobacterial Clinical and Research Program