Stephen Juvet

Stephen Juvet is a respirologist and physician-scientist with the Toronto Lung Transplant Program.  Dr. Juvet obtained his MD in 2002 from the University of Toronto.  He went on to train in internal and respiratory medicine at the University of Toronto.  Dr. Juvet then completed his PhD in T cell biology in the Institute of Medical Science, followed by a postdoctoral fellowship in transplantation immunology at the University of Oxford.  As a lung transplant respirologist, Dr. Juvet is involved in the care of patients before and after lung transplantation.  His research focus is on achieving immunological tolerance in lung transplantation.
Lung transplantation has the poorest outcome of all solid organ transplants, due to a high rate of chronic lung allograft dysfunction (CLAD).  Work in the laboratory is conducted on mouse and rat models of lung transplantation and on human samples. 

Dr. Juvet’s research is focused on three primary areas: 1) Determining how pulmonary antigen-presenting and immunoregulatory cells influence the development of anti-donor responses within the lung and the pathogenesis of CLAD, with the goal of modulating these processes to promote graft acceptance; 2) determining how pulmonary tertiary lymphoid structures are formed following lung transplantation and contribute to CLAD; 3) assessing how ischemia-reperfusion injury and other early allograft events influence the recipient’s immune response to the lung allograft, with a view to intervening at this stage to prevent CLAD development.  Finally, Dr. Juvet is also interested in developing novel immunodiagnostic methods to better predict the outcome of transplantation and the effectiveness of immunosuppressive therapy. 
J Vis Exp. 2017 Apr 19;(122):
Juvet SC, Moshkelgosha S, Sanderson S, Hester J, Wood KJ, Bushell A
J Heart Lung Transplant. 2016 Apr;35(4):518-27
Oishi H, Martinu T, Sato M, Matsuda Y, Hirayama S, Juvet SC, Guan Z, Saito T, Cypel M, Hwang DM, Keller TL, Whitman MR, Liu M, Keshavjee S
Am J Transplant. 2016 May;16(5):1394-407
Juvet SC, Sanderson S, Hester J, Wood KJ, Bushell A
Am J Transplant. 2014 Apr;14(4):750-63
Juvet SC, Whatcott AG, Bushell AR, Wood KJ
PLoS One. 2013;8(6):e65253
Juvet SC, Thomson CW, Kim EY, Han M, Zhang L
Transplantation. 2012 Jun 27;93(12):1212-20
Wagnetz D, Sato M, Hirayama S, Matsuda Y, Juvet SC, Yeung JC, Guan Z, Zhang L, Liu M, Waddell TK, Keshavjee S
J Autoimmun. 2013 May;42:80-93
Juvet SC, Thomson CW, Kim EY, Joe B, Adeyi O, Zhang L
PLoS One. 2012;7(10):e47732
Juvet SC, Han M, Vanama R, Joe B, Kim EY, Zhao FL, Jeon C, Adeyi O, Zhang L
Eur J Immunol. 2011 Sep;41(9):2699-708
Gao JF, McIntyre MS, Juvet SC, Diao J, Li X, Vanama RB, Mak TW, Cattral MS, Zhang L

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Assistant Professor and Clinician-Scientist, Department of Medicine, Division of Respirology and Toronto Lung Transplant Program - University of Toronto