Leonardo Salmena, PhD

Our ongoing scientific interests include investigations of signalling perturbations in the oncogenic PI3-kinase pathway, specifically the function and aberrations of the tumor suppressor PTEN in the context of leukemogenesis. We are currently investigating post-translational mechanisms of PTEN regulation and control of PTEN expression by microRNA.

We have recently identified a novel post-transcriptional mechanism of gene regulation of PTEN mediated through competitive interaction of cellular RNA molecules. These findings have opened a new field of study which embraces the notion that all cellular RNA molecules (coding and non-coding) have the ability to compete for microRNA binding and thereby mediate their relative functions in trans. Future studies include functional analyses of the non-coding transcriptome, its aberrant regulation, and the consequences for human disease and cancer.

We also have a keen and ongoing interest in the generation of innovative genetically modified mouse models. The design of such models is aimed to elucidate and faithfully model the genomic alterations leading to disease and cancer for the purpose of preclinical studies.

Finally, working closely with Dr. Mark Minden, we are intensely investigating the genetic alterations and molecular mechanisms that underlie the pathogenesis of human leukemias, with the aim of identifying potential targets and novel strategies for disease prevention.
Oncotarget. 2019 Oct 29;10(59):6378-6390
Mangialardi EM, Chen K, Salmon B, Vacher J, Salmena L
Oncotarget. 2019 Mar 29;10(25):2475-2483
Zaman T, Sun P, Narod SA, Salmena L, Kotsopoulos J
Cancer Causes Control. 2018 Apr 20;:
Moran O, Zaman T, Eisen A, Demsky R, Blackmore K, Knight JA, Elser C, Ginsburg O, Zbuk K, Yaffe M, Narod SA, Salmena L, Kotsopoulos J
PLoS One. 2018;13(2):e0191510
Dzneladze I, Woolley JF, Rossell C, Han Y, Rashid A, Jain M, Reimand J, Minden MD, Salmena L
Oncotarget. 2016 Nov 22;:
Odén L, Akbari M, Zaman T, Singer CF, Sun P, Narod SA, Salmena L, Kotsopoulos J
Breast Cancer Res. 2016;18(1):87
Chehade R, Pettapiece-Phillips R, Salmena L, Kotlyar M, Jurisica I, Narod SA, Akbari MR, Kotsopoulos J
Methods Mol Biol. 2016;1388:v
Salmena L, Stambolic V
Methods Mol Biol. 2016;1388:39-51
Woolley JF, Salmena L
Methods Mol Biol. 2016;1388:3-11
Salmena L