Kenneth R. Chapman

Kenneth R. Chapman, MSc, MD, FRCPC, FACP, FERS

Clinical Researcher, Krembil Research Institute (Krembil)
Keywords: asthma, respiratory illness, chronic obstructive pulmonary disease (COPD)
Professor Kenneth Chapman the first recipient of the University Health Network's GSK-CIHR Chair in Respiratory Healthcare Delivery. This multi-year award recognizes and encourages his broad program of research designed to assess, improve and disseminate optimal strategies for managing the common respiratory illnesses, asthma and chronic obstructive pulmonary disease (COPD). Dr. Chapman is an internationally respected researcher in the field of asthma, COPD and airway diseases; his publications have appeared in the New England Journal of Medicine and Lancet. The titles of more than 400 publications have ranged from " Emergency medical services for outdoor rock music festivals" to "The effect of posture on thoracoabdominal movements during progressive hyperoxic hypercapnia in conscious man" . With more the 6,000 citations to his work, Professor Chapman is in the top 1% of cited medical researchers.

Dr. Chapman is currently Director of the Asthma and Airway Centre of the University Health Network and Director of the Canadian Registry for Alpha1 Antitrypsin Deficiency. Previously, he was the Canadian Network for Asthma Care. His academic appointments are as Professor of Medicine in the Faculty of Medicine with a cross-appointment to the School of Graduate Studies (Institute of Medical Science). He has supervised graduate students of varied backgrounds at the MSc and PhD levels.
  • Asthma management strategies
    It is now a standard of care that patients with unstable asthma are given a short course of oral steroids in hospital emergency rooms, walk-in clinics and offices to allow their safe discharge home. This strategy was first examined rigorously by Dr. Chapman and his colleagues who published their pivotal study in the New England Journal of Medicine (see below). This was followed by other studies examining the optimal strategies for managing asthma.

    • Chapman KR, Verbeek, PR, White JG, Rebuck AS. Effect of a short course oral prednisone in the prevention of early relapse after the emergency room treatment of acute asthma. N Engl J Med 1991; 324: 788-794.

    • Chapman KR, Kesten S, Szalai JP. Regular versus as-needed use of inhaled salbutamol in asthma control. Lancet 1994; 1379-1382.

    • Hanania NA, Chapman KR, Sturtridge WC, Kesten S. Dose-related decrease in bone density among asthmatic patients treated with inhaled corticosteroids. J Allergy Clin Immunol 1995; 96: 571-579.

    • Chapman KR, Barnes NC, Greening AP, Jones PW, Pedersen S. Single maintenance and reliever therapy (SMART) of asthma: a critical appraisal. Thorax 2010; 65:747-752.

    • Fritscher LG, Marras TK, Bradi AC, Fritscher CC, Balter MS, Chapman KR. Non-tuberculous mycobacterial (NTM) infection as a cause of difficult-to-control asthma: a case control study. Chest 2011 Jan; 139: 23-7.
  • Patient education

    Optimizing asthma treatment outcomes requires studies on patient education, compliance, and control assessment. Recognizing this, Dr. Chapman founded the Canadian Network for Respiratory Care, an organization that manages respiratory educator certification programs for Canada. He remains active on its executive.

    • Hanania NA, Wittman R, Kesten S, Chapman KR. Medical personnnel's knowledge of and ability to use inhaling devices. Chest 1994; 105: 111-116.

    • Chapman KR, Ernst P, Grenville A, Dewland P, Zimmerman S. Control of asthma in Canada: failure to achieve guideline targets. Can Respir J 2001; 35A-40A.

    • Chapman KR, Boulet LP, Rea RM, Franssen E. Sub-optimal asthma control: prevalence, detection and consequences in primary practice. Eur Respir J 2008; 31: 320-325.
  • Chronic obstructive pulmonary disease (COPD)
    Dr. Chapman wrote Canada's first guidelines for the management of COPD and maintains a broad program of research in this area, addressing issues of diagnostic delay, epidemiology and non-invasive monitoring. He is a member of the CanCOLD consortium, a trans-Canadian program of study examining the natural history in a large population-based cohort of patients with COPD. He has addressed issues of gender bias in his work.

    • Chapman KR, Bowie D, Hodder R, Julien M, Kesten S, Newhouse M, Pare PD. Canadian Thoracic Society Concensus Statement on the assessment and management of COPD. Can Med Assoc J 1992; 147: 421-428.

    • Kesten S. Chapman KR. Physician perceptions and management of COPD. Chest 1993; 104: 254-258.

    • Chapman KR, Tashkin DP, Pye DJ. Gender bias in the diagnosis of COPD. Chest 2001; 119: 1691-1695.

    • Chapman KR, Mannino DM, Soriano JB, Vermeire PA, Buist AS, Thun MJ, Connell C, Jemal A, Lee TA, Miravitlles M, Aldington S, Beasley R. Epidemiology and costs of chronic obstructive pulmonary disease. Eur Respir J 2006; 27: 188-207.
  • Alpha1 antitrypsin deficiency
    Dr. Chapman follows a large number of patients with alpha1 antitrypsin deficiency and is considered one of the world's experts in this comparatively rare lung disease. His work reflects both the Canadian perspective (from the Canadian registry) and his collaboration with international colleagues.

    • Chapman KR, Stockley RA, Dawkins C, Wilkes MM, Navickis RJ. Augmentation therapy for α1 antitrypsin deficiency: a meta-analysis. J COPD 2009; 6: 177-184.
Overall and Cardiovascular Safety of Aclidinium Bromide in Patients With COPD: A Pooled Analysis of Six Phase III, Placebo-Controlled, Randomized Studies.
Chronic Obstr Pulm Dis. 2015 Dec 22;3(1):435-445
Chapman KR, Beck E, Alcaide D, Garcia Gil E
QVA149 Improves Lung Function, Dyspnea, and Health Status Independent of Previously Prescribed Medications and COPD Severity: A Subgroup Analysis from the SHINE and ILLUMINATE Studies.
Chronic Obstr Pulm Dis. 2015 Jan 01;2(1):48-60
Chapman KR, Bateman ED, Chen H, Hu H, Fogel R, Banerji D
The Effect of Alpha-1 Proteinase Inhibitor on Biomarkers of Elastin Degradation in Alpha-1 Antitrypsin Deficiency: An Analysis of the RAPID/RAPID Extension Trials.
Chronic Obstr Pulm Dis. 2016 Nov 18;4(1):34-44
Ma S, Lin YY, Cantor JO, Chapman KR, Sandhaus RA, Fries M, Edelman JM, McElvaney G, Turino GM
Quantitative Disease Progression Model of Alpha-1 Proteinase Inhibitor Therapy on CT Lung Density in Patients with Alpha-1 Antitrypsin Deficiency.
Br J Clin Pharmacol. 2017 Jun 29;:
Tortorici MA, Rogers JA, Vit O, Bexon M, Sandhaus RA, Burdon J, Chorostowska-Wynimko J, Thompson P, Stocks J, McElvaney NG, Chapman KR, Edelman JM
Reply to Correspondence Letter Regarding "Blood Eosinophils and Response to Maintenance COPD Treatment: Data from the FLAME Trial".
Am J Respir Crit Care Med. 2017 Jun 26;:
Roche N, Chapman KR, Vogelmeier CF, Herth FJF, Thach C, Fogel R, Olsson P, Patalano F, Banerji D, Wedzicha JA
Blood Eosinophils and Response to Maintenance COPD Treatment: Data from the FLAME Trial.
Am J Respir Crit Care Med. 2017 Mar 09;:
Roche N, Chapman KR, Vogelmeier CF, Herth FJ, Thach C, Fogel R, Olsson P, Patalano F, Banerji D, Wedzicha JA
Long-term efficacy and safety of α1 proteinase inhibitor treatment for emphysema caused by severe α1 antitrypsin deficiency: an open-label extension trial (RAPID-OLE).
Lancet Respir Med. 2016 Dec 01;:
McElvaney NG, Burdon J, Holmes M, Glanville A, Wark PA, Thompson PJ, Hernandez P, Chlumsky J, Teschler H, Ficker JH, Seersholm N, Altraja A, Mäkitaro R, Chorostowska-Wynimko J, Sanak M, Stoicescu PI, Piitulainen E, Vit O, Wencker M, Tortorici MA, Fries...
Findings on Thoracic Computed Tomography Scans and Respiratory Outcomes in Persons with and without Chronic Obstructive Pulmonary Disease: A Population-Based Cohort Study.
PLoS One. 2016;11(11):e0166745
Tan WC, Hague CJ, Leipsic J, Bourbeau J, Zheng L, Li PZ, Sin DD, Coxson HO, Kirby M, Hogg JC, Raju R, Road J, O'Donnell DE, Maltais F, Hernandez P, Cowie R, Chapman KR, Marciniuk DD, FitzGerald JM, Aaron SD, Canadian Respiratory Research Network and...
Improving the Management of COPD in Women.
Chest. 2016 Nov 2;:
Jenkins CR, Chapman KR, Donohue JF, Roche N, Tsiligianni I, Han MK
Practice Effects on Story Memory and List Learning Tests in the Neuropsychological Assessment of Older Adults.
PLoS One. 2016;11(10):e0164492
Gavett BE, Gurnani AS, Saurman JL, Chapman KR, Steinberg EG, Martin B, Chaisson CE, Mez J, Tripodis Y, Stern RA

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Clinical Researcher, Krembil Research Institute (Krembil)

Director, Asthma & Airway Centre, University Health Network
Professor of Medicine, University of Toronto