Herbert P von Schroeder, BSc, MSc, MD, FRCSC

Intercellular Communication Between Osteoblastic Cells and Vascular Cells
The major research interest in my lab is the intercellular communication between osteoblastic cells and vascular cells. It has long been known that bone formation cannot occur without a blood supply. More importantly, cells of the vascular system communicate with osteoblast cells, and the signaling between these two cell types may be the target of certain diseases and drugs including glucocorticoids. Alteration is this signaling axis may result or promote certain pathological conditions of bone including osteoporosis.

Using culture systems consisting of osteoblastic cells and vascular endothelial cells, our investigations have demonstrated that endothelin-1, a vascular polypeptide, stimulates osteoblast differentiation and bone production. This effect is additive to the known stimulatory effects of the steroid dexamethasone, and our microarray experiments have shown that the two factors control osteoblastic cells by unique mechanisms. Present investigations are looking at the roles of VEGF, Osterix and Cbfa1 in this system.
J Hand Surg Eur Vol. 2019 Jul 04;:1753193419859373
Cheng H, Novak CB, Veillette C, von Schroeder HP
Can J Surg. 2019 Mar 22;62(3):1-3
Roy M, Novak CB, Urbach DR, McCabe SJ, von Schroeder HP, Okrainec K
Hand (N Y). 2019 Feb 14;:1558944719828005
Zuo KJ, Saggaf M, von Schroeder HP, Binhammer P
Plast Reconstr Surg. 2019 Feb;143(2):350e-358e
Roy M, Okrainec K, Novak CB, von Schroeder HP, Urbach DR, McCabe SJ
J Hand Surg Am. 2018 Nov 09;:
Novak CB, Li Y, von Schroeder HP, Anastakis DJ, McCabe SJ
World J Surg. 2018 Aug 13;:
Roy M, Corkum JP, Urbach DR, Novak CB, von Schroeder HP, McCabe SJ, Okrainec K
J Hand Surg Am. 2017 Dec 11;:
von Schroeder HP
J Surg Educ. 2017 Mar 22;:
Yeung C, McMillan C, Saun TJ, Sun K, D'hondt V, von Schroeder HP, Martou G, Lee M, Liao E, Binhammer P
J Hand Surg Eur Vol. 2015 Dec 2;
Plant MA, Novak CB, McCabe SJ, von Schroeder HP
J Emerg Med. 2015 Oct 12;
McEvenue G, FitzPatrick F, von Schroeder HP



Associate Professor, Surgery, University of Toronto