Herbert P von Schroeder, BSc, MSc, MD, FRCSC

Intercellular Communication Between Osteoblastic Cells and Vascular Cells
The major research interest in my lab is the intercellular communication between osteoblastic cells and vascular cells. It has long been known that bone formation cannot occur without a blood supply. More importantly, cells of the vascular system communicate with osteoblast cells, and the signaling between these two cell types may be the target of certain diseases and drugs including glucocorticoids. Alteration is this signaling axis may result or promote certain pathological conditions of bone including osteoporosis.

Using culture systems consisting of osteoblastic cells and vascular endothelial cells, our investigations have demonstrated that endothelin-1, a vascular polypeptide, stimulates osteoblast differentiation and bone production. This effect is additive to the known stimulatory effects of the steroid dexamethasone, and our microarray experiments have shown that the two factors control osteoblastic cells by unique mechanisms. Present investigations are looking at the roles of VEGF, Osterix and Cbfa1 in this system.
J Wrist Surg. 2019 Dec;8(6):497-502
Dreckmann SC, von Schroeder HP, Novak CB, Baltzer HL
Can J Surg. 2019 Dec 01;62(6):016218
Armstrong KA, von Schroeder HP, Baxter NN, Zhong T, Huang A, McCabe SJ
Can J Surg. 2019 Sep 23;62(6):016218
Armstrong KA, von Schroeder HP, Baxter NN, Zhong T, Huang A, McCabe SJ
J Hand Surg Eur Vol. 2019 Jul 04;:1753193419859373
Cheng H, Novak CB, Veillette C, von Schroeder HP
Can J Surg. 2019 Mar 22;62(3):1-3
Roy M, Novak CB, Urbach DR, McCabe SJ, von Schroeder HP, Okrainec K
Hand (N Y). 2019 Feb 14;:1558944719828005
Zuo KJ, Saggaf M, von Schroeder HP, Binhammer P
Plast Reconstr Surg. 2019 Feb;143(2):350e-358e
Roy M, Okrainec K, Novak CB, von Schroeder HP, Urbach DR, McCabe SJ
J Hand Surg Am. 2018 Nov 09;:
Novak CB, Li Y, von Schroeder HP, Anastakis DJ, McCabe SJ
World J Surg. 2018 Aug 13;:
Roy M, Corkum JP, Urbach DR, Novak CB, von Schroeder HP, McCabe SJ, Okrainec K



Associate Professor, Surgery, University of Toronto