David Kirsch, MD, PhD

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Dr. Kirsch is a radiation oncologist with expertise caring for patients with bone and soft tissue sarcomas. He has received a number of awards for his research accomplishments and several awards for mentoring including the 2014 Duke University Dean’s Award for Excellence in Mentoring and the 2021 Career Mentoring Award in Basic Translational Science from the Duke University School of Medicine.

Our laboratory utilizes sophisticated genetically engineered experimental models known as GEMMs to study mechanisms of sarcoma development and the response of tumours and normal tissues to radiation therapy alone or in combination with immunotherapy.

Using a combination of GEMMs, cell lines, and human samples, we study mechanisms of sarcoma development, metastasis, and response to therapy. Current projects utilize cutting-edge tools in molecular and cell biology, genetics, genomics, and imaging to study sarcomas initiated by the CIC-DUX4 fusion protein, loss of SMARCB1, and loss of the tumour suppressor genes p53, Rb, and ATRX.

For a list of Dr. Kirsch's publications, please visit PubMedScopus or ORCID.

Head, Radiation Medicine Program, Princess Margaret Cancer Centre
Head, Department of Radiation Oncology, University Health Network
Professor, Departments of Radiation Oncology and Molecular Biophysics, University of Toronto