Bruce A Perkins, MD


 

Dr. Bruce Perkins is Professor of Medicine at the Division of Endocrinology and Metabolism, and the Institute of Health Policy, Management and Evaluation, University of Toronto. He obtained his MD and Internal Medicine training at the University of Toronto, his endocrinology subspecialty training at Harvard University, his Masters of Public Health in Epidemiology at the Harvard School of Public Health, and a research fellowship in epidemiology at the Joslin Diabetes Center.

He serves as a member of the Steering Committee and Chair, Microvascular Complications on Diabetes Canada’s Clinical Practice Guidelines Committee, leads the CIHR/SPOR-funded Diabetes Action Canada Clinical Trials Goal Group, and was the recipient of the Canadian Diabetes Association – Canadian Institutes of Health Research 2015 Young Scientist Award.

My research initiatives focus on using epidemiological techniques to explore the natural history of diabetes complications and novel strategies for their prevention. My major clinical research areas include:
  • The Diagnosis and Prediction of Diabetic Neuropathy.
    Injury to peripheral nerves is the most common diabetes complication but lacks a valid and feasible biomarker to identify early disease and its progression. Dr. Perkins has looked to in vivo Corneal Confocal Microscopy, a novel technique that non-invasively images the health of small nerve fibres that terminate in the cornea of the eye. He leads an NIH-funded consortium project to establish its role as a clinical and research endpoint. [Funding: CDA, JDRF, NIH] 
     
  • Diabetic Kidney Disease Prediction and Identification of Novel Causative Factors and Interventions.

    Dr. Perkins' work has helped to create a new paradigm for nephropathy where early renal function loss, not albuminuria, is the primary disease process leading to advanced kidney disease. Examination of this new model has revealed novel causative factors including uric acid that have been implemented in a NIH-funded international randomized controlled trial led by the Preventing Early Renal Loss (PERL) Consortium. Dr. Perkins' also explores mechanisms of complications by studying people with type 1 diabetes with greater than 50 years of diabetes duration (www.diabeteslongevity.com). [Funding: JDRF, NIH] 

  • Novel Glycemic Intervention for Type 1 Diabetes.

    Despite major advances in the nature and delivery of intensive insulin therapy, only a small proportion of patients achieve their glycemic targets. Dedicated to this fundamental challenge, Dr. Perkins' aggressively examines the use of non-insulin glycemic therapies that are currently available to patients with type 2 diabetes (such as SGLT2 inhibition), and makes novel contributions to existing models for the Artificial Pancreas. [Funding: CDA, CIHR-SPOR, CIHR, Boehringer-Ingelheim] 

J Diabetes Complications. 2019 Jun 20;:107397
Cardinez N, Lovblom LE, Orszag A, Bril V, Cherney DZ, Perkins BA
Can J Diabetes. 2019 Aug 14;:
Ostrovski I, Lovblom LE, Scarr D, Weisman A, Cardinez N, Orszag A, Falappa CM, D'Aoust É, Haidar A, Rabasa-Lhoret R, Legault L, Perkins BA
Can J Diabetes. 2019 Aug 22;:
Brockman NK, Sigal RJ, Kenny GP, Riddell MC, Perkins BA, Yardley JE
Neurol Neuroimmunol Neuroinflamm. 2019 Sep;6(5):
Breiner A, Barnett Tapia C, Lovblom LE, Perkins BA, Katzberg HD, Bril V
Can J Diabetes. 2019 Jun 13;:
Cardinez N, Opsteen C, Perkins BA
Kidney Int Rep. 2019 Jun;4(6):786-796
Scarr D, Bjornstad P, Lovblom LE, Lovshin JA, Boulet G, Lytvyn Y, Farooqi MA, Lai V, Orszag A, Weisman A, Keenan HA, Brent MH, Paul N, Bril V, Cherney DZI, Perkins BA
J Diabetes Complications. 2019 Aug;33(8):547-549
Bjornstad P, Lovshin JA, Lytvyn Y, Lovblom LE, Scarr D, Boulet G, Farooqi MA, Orszag A, Bai JW, Weisman A, Keenan HA, Brent MH, Paul N, Bril V, Perkins BA, Cherney DZI
Diabetes Care. 2019 Jun 08;:
Perkins BA, Rosenstock J, Skyler JS, Laffel LM, Cherney DZ, Mathieu C, Pang C, Wood R, Kinduryte O, George JT, Marquard J, Soleymanlou N
Ren Fail. 2019 Nov;41(1):427-433
Sekercioglu N, Lovblom LE, Bjornstad P, Lovshin JA, Lytvyn Y, Boulet G, Farooqi MA, Orszag A, Lai V, Tse J, Cham L, Keenan HA, Brent MH, Paul N, Bril V, Perkins BA, Cherney DZI
Diabetes. 2019 Aug;68(8):1649-1662
Tang Y, Lenzini PA, Pop-Busui R, Ray PR, Campbell H, Perkins BA, Callaghan B, Wagner MJ, Motsinger-Reif AA, Buse JB, Price TJ, Mychaleckyj JC, Cresci S, Shah H, Doria A

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Professor, Department of Medicine, Division of Endocrinology and Metabolism, University of Toronto
Cross-appointment, Institute of Health Policy, Management and Evaluation, University of Toronto
Staff Endocrinologist, Mount Sinai Hospital and University Health Network, Toronto