Bruce A Perkins, MD


 

Dr. Bruce Perkins is Professor of Medicine at the Division of Endocrinology and Metabolism, and the Institute of Health Policy, Management and Evaluation, University of Toronto. He obtained his MD and Internal Medicine training at the University of Toronto, his endocrinology subspecialty training at Harvard University, his Masters of Public Health in Epidemiology at the Harvard School of Public Health, and a research fellowship in epidemiology at the Joslin Diabetes Center.

He serves as a member of the Steering Committee and Chair, Microvascular Complications on Diabetes Canada’s Clinical Practice Guidelines Committee, leads the CIHR/SPOR-funded Diabetes Action Canada Clinical Trials Goal Group, and was the recipient of the Canadian Diabetes Association – Canadian Institutes of Health Research 2015 Young Scientist Award.

My research initiatives focus on using epidemiological techniques to explore the natural history of diabetes complications and novel strategies for their prevention. My major clinical research areas include:
  • The Diagnosis and Prediction of Diabetic Neuropathy.
    Injury to peripheral nerves is the most common diabetes complication but lacks a valid and feasible biomarker to identify early disease and its progression. Dr. Perkins has looked to in vivo Corneal Confocal Microscopy, a novel technique that non-invasively images the health of small nerve fibres that terminate in the cornea of the eye. He leads an NIH-funded consortium project to establish its role as a clinical and research endpoint. [Funding: CDA, JDRF, NIH] 
     
  • Diabetic Kidney Disease Prediction and Identification of Novel Causative Factors and Interventions.

    Dr. Perkins' work has helped to create a new paradigm for nephropathy where early renal function loss, not albuminuria, is the primary disease process leading to advanced kidney disease. Examination of this new model has revealed novel causative factors including uric acid that have been implemented in a NIH-funded international randomized controlled trial led by the Preventing Early Renal Loss (PERL) Consortium. Dr. Perkins' also explores mechanisms of complications by studying people with type 1 diabetes with greater than 50 years of diabetes duration (www.diabeteslongevity.com). [Funding: JDRF, NIH] 

  • Novel Glycemic Intervention for Type 1 Diabetes.

    Despite major advances in the nature and delivery of intensive insulin therapy, only a small proportion of patients achieve their glycemic targets. Dedicated to this fundamental challenge, Dr. Perkins' aggressively examines the use of non-insulin glycemic therapies that are currently available to patients with type 2 diabetes (such as SGLT2 inhibition), and makes novel contributions to existing models for the Artificial Pancreas. [Funding: CDA, CIHR-SPOR, CIHR, Boehringer-Ingelheim] 

Diabetes Obes Metab. 2019 May 21;:
Weisman A, Tomlinson GA, Lipscombe LL, Perkins BA, Hawker GA
J Diabetes Complications. 2018 Dec 22;:
Alhuzaim ON, Lewis EJH, Lovblom LE, Cardinez M, Scarr D, Boulet G, Weisman A, Lovshin JA, Lytvyn Y, Keenan HA, Brent MH, Paul N, Bril V, Cherney DZI, Perkins BA
Diabetologia. 2019 Jun;62(6):1090-1093
Kopecky C, Lytvyn Y, Domenig O, Antlanger M, Kovarik JJ, Kaltenecker CC, Poglitsch M, Perkins BA, Rye KA, Cherney DZI, Säemann MD
Can J Neurol Sci. 2019 May;46(3):337-341
Abraham A, Katzberg HD, Lovblom LE, Perkins BA, Bril V
Diabetes Care. 2019 May;42(5):883-890
Perkins BA, Bebu I, de Boer IH, Molitch M, Tamborlane W, Lorenzi G, Herman W, White NH, Pop-Busui R, Paterson AD, Orchard T, Cowie C, Lachin JM, Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications ...
Muscle Nerve. 2018 06;57(6):1018-1021
Abraham A, Barnett C, Katzberg HD, Lovblom LE, Perkins BA, Bril V
Am J Kidney Dis. 2019 Feb 22;:
Lytvyn Y, Bjornstad P, Lovshin JA, Boulet G, Farooqi MA, Lai V, Tse J, Cham L, Lovblom LE, Weisman A, Keenan HA, Brent MH, Paul N, Bril V, Advani A, Sochett E, Perkins BA, Cherney DZI
Diabetes Obes Metab. 2019 Feb 13;:
Lytvyn Y, Bjornstad P, Lovshin JA, Singh SK, Boulet G, Farooqi MA, Lai V, Tse J, Cham L, Lovblom LE, Weisman A, Keenan HA, Brent MH, Paul N, Bril V, Advani A, Sochett E, Perkins BA, Cherney DZI
Diabetes Obes Metab. 2019 Feb 08;:
Weisman A, Tomlinson GA, Lipscombe LL, Perkins BA, Hawker GA
Diabetes Care. 2018 Dec 06;:
Lovshin JA, Lytvyn Y, Lovblom LE, Katz A, Boulet G, Bjornstad P, Lai V, Cham L, Tse J, Orszag A, Keenan HA, Paul N, Bril V, Wong DT, McReelis KD, Brent MH, Perkins BA, Cherney DZI

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Professor, Department of Medicine, Division of Endocrinology and Metabolism, University of Toronto
Cross-appointment, Institute of Health Policy, Management and Evaluation, University of Toronto
Staff Endocrinologist, Mount Sinai Hospital and University Health Network, Toronto