Drug Development Program, Princess Margaret Hospital
Ontario Cancer Institute (OCI)
Keywords: phase I clinical trials, molecular targeted agents, clinical trial design and methodology, head and neck malignancies
Developmental Therapeutics and Phase I Clinical Trials of Novel Agents
Dr. Lillian Siu is a Senior Staff Physician in the Division of Medical Oncology and Hematology at Princess Margaret Hospital since 1998, and is a Professor of Medicine at the University of Toronto. Dr. Siu is Director of the Phase I Program and Co-Director of the Robert and Maggie Bras and Family Drug Development Program at Princess Margaret Hospital.
Dr. Siu's major research focus is in the area of new anticancer drug development, particularly with respect to phase I trials and head and neck malignancies. She is the principal investigator of a phase I cooperative agreement U01 award (2008-2013) sponsored by the United States National Cancer Institute, which aims to expedite the access and evaluation of novel anti-cancer agents.
Dr. Siu is the recipient of national and international awards such as the Elsie Winifred Crann Award from the University of Toronto in 2001 and the Michaele C.Christian Award in Oncology Drug Development from the US National Cancer Institute in 2010. Internationally, Dr. Siu has been a member of the AACR International Membership Committee, the ASCO Head and Neck Cancer Scientific Program Subcommittee, and the EORTC Protocol Review Committee. Dr. Siu was the Neuroendocrine Tumor Task Force Chair in the North American Gastrointestinal Intergroup Scientific Steering Committee from 2007-2009; and she was the ASCO Grants Selection Committee Chair in 2009-10. In 2009, Dr. Siu has been awarded a Cancer Care Ontario Tier 1 Chair in Experimental Therapeutics. Dr. Siu has a strong background in clinical trial methodology and has been a member of the Program Committees for both the ECCO/ASCO/AACR workshop in Flims, Switzerland and the AACR/ASCO workshop in Vail, Colorado. Dr. Siu has published over 110 peer-reviewed manuscripts, and she is currently on the Editorial Boards of Journal of Clinical Oncology, European Journal of Cancer, and Cancer Discovery.
Professor of Medicine, University of Toronto
Cancer Care Ontario Research Chair, Experimental Therapeutics