Research at University Health Network
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Fei-Fei Liu, MD, FRCPC
Senior Scientist, Princess Margaret Cancer Centre
Scientific Division Head: Research, Princess Margaret Cancer Centre
Cancer Clinical Research Unit (CCRU), Princess Margaret Cancer Centre
Keywords: Drug discovery, Head & neck cancers, High-throughput screens, miRNA/mRNA global profiling & characterization, Adipose derived stem cell, Radiation induced normal tissue injury, Regenerative medicine 

Research Interests
Our lab is focused on several aspects of translational molecular oncology, including the development of biomarkers for head & neck cancers, high-throughput screens to identify novel anti-cancer therapeutics, and stem cell regenerative therapy. Using DNA, RNA, and protein extracted from diagnostic human cancer samples, we are in the process of conducting multi-omic global expression analyses. Preliminary data are very promising, and in addition to identifying multi-dimensional predictive/prognostic signatures for improving cancer patient management, we are also studying their related pathways and biological functions in preclinical models of human cancers. Automated robotic screens are being used to identify corresponding novel anti-cancer compounds, and characterization of these potential new therapeutics is underway. Finally, we are also interested in understanding how adipose derived stem cells may aid in tissue regeneration after treatment with ionizing radiation.

Additional Appointments
  • Professor, Radiation Oncology, University of Toronto

  • Professor, Medical Biophysics, University of Toronto

  • Professor, Otolaryngology, University of Toronto

  • Staff Radiation Oncologist, Princess Margaret Cancer Centre

  • Dr. Mariano Elia Chair in Head and Neck Oncology

Pubmed Publications
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Selected Publications

  • How C, Hui AB, Alajez NM, Shi W, Boutros PC, Clarke BA, Yan R, Pintilie M, Fyles A, Hedley DW, Hill RP, Milosevic M, Liu FF. MicroRNA-196b Regulates the Homeobox B7-Vascular Endothelial Growth Factor Axis in Cervical Cancer. PLOS ONE. 8(7): e67846, 2013.

  • Hui AB, Lin A, Xu W, Waldron L, Perez-Ordonez B, Weinreb I, Shi W, Bruce J, Huang SH, OSullivan B, Waldron J, Gullane P, Irish JC, Chan K, Liu FF. Potentially prognostic miRNAs in HPV-associated oropharyngeal carcinoma. Clin Cancer Res. 19(8):2154-2162, 2013.

  • Sepiashvili L, Hui A, Ignatchenko V, Shi W, Su S, Xu W, Huang SH, OSullivan B, Waldron J, Irish JC, Perez-Ordonez B, Liu FF, Kislinger T. Potentially novel candidate biomarkers for head and neck squamous cell carcinoma identified using an integrated cell line-based discovery strategy. Mol Cell Proteomics. 11(11):1404-1415, 2012.

  • Ito E, Yue S, Moriyama E, Kim I, Hui A, Shi W, Alajez N, Bhogal N, Li GH, Datti A, Schimmer A, Liu P, Durocher D, Neel B, OSullivan B, Cummings B, Bristow R, Liu FF. Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer. Science Translational Medicine. 3:67ra7, 2011.
Related Webpages
  Fei-Fei Liu
Mailing Address
Primary LAB
Princess Margaret Cancer Centre
610 University Ave
7 7-611
610 University Avenue
Toronto, Ontario
Canada M5G 2M9


Phone Numbers
416.946.4501 x2123(Primary)
416-946-4501, ext. 5620 or 5623 (Lab)(Additional)

Staff and Trainees
Wendy Zhang
Xia Yu
Jian-Hua Li
Barbara L Bachtiary
Nehad M Alajez
Kenneth W Yip
Carlo Bastianutto
Marie C Chia
Willa Shi
Joseph Mocanu
Joseph D Martin

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