Keywords: diabetes, lipoproteins/dyslipidemia, HDL, VLDL, insulin resistance, in vivo human physiology research |
The Lewis lab has had a long interest in the mechanisms of various aspects of diabetic dyslipidemia, including postprandial lipemia, HDL lowering and hypertriglyceridemia. We have also had a long standing interest in the interaction between free fatty acids and pancreatic beta cell dysfunction. Previously we have performed both animal and human mechanistic studies but currently are focusing exclusively on the human. In 2002, working in close collaboration with Dr. Khosrow Adeli (U of T), we made the novel observation that the intestine, in addition to the liver, overproduces lipoproteins in insulin resistant states. In our current CIHR-funded work we are determining the mechanism of intestinal and hepatic lipoprotein overproduction in insulin resistance and Type 2 diabetes. We perform integrative, physiological studies in humans, attempting to determine the regulation of intestinal and hepatic lipoprotein particle production by hormones, nutrients and pharmacological agents.
- Professor, Departments of Medicine and Physiology, University of Toronto
- Director, Banting and Best Diabetes Centre, University of Toronto
- Director, Division of Endocrinology and Metabolism, University of Toronto
- Sun Life Financial Chair in Diabetes
- Drucker Family Chair in Diabetes Research
Toronto Medical Discovery Tower
10th Floor Room 203
101 College St.
Canada M5G 1L7
Toronto General Hospital
Eaton North Wing
12th Floor Room 244
200 Elizabeth St.
Canada M5G 2C4
|Changting Xiao |
|Satya Dash |
|Linda Szeto |
|Brenda Hughes |
|Patricia Harley |
|Kristine Puzeris |