Dr. Hofer obtained his medical degree from the University of Amsterdam in 1992. He then completed his PhD studying tissue oxygen tension as an indicator of tissue perfusion in the Department of Surgical Research, Academic Medical Center, Amsterdam. He obtained his board certification in Plastic Surgery from the Netherlands in 2000 and became the first Plastic Surgeon to be awarded the highly prestigious Dutch Cancer Society clinical fellowship, which funded his one-year Microsurgery Research fellowship at the Bernard O'Brien Institute of Microsurgery at St. Vincent's Hospital and the University of Melbourne in Melbourne, Australia. Dr. Hofer is internationally recognized for his outstanding contributions in the areas of clinical service, education, and research. Prior to becoming the Division's first international candidate to be recruited in over a decade, Dr. Hofer was an Associate Professor in the Department of Plastic and Reconstructive Surgery, Erasmus Medical Center, Rotterdam and the Head of Plastic and Reconstructive Surgical Oncology.
- Innovative Surgical TechniquesMy main clinical research interest is in the development, refinement and evaluation of innovative plastic and reconstructive surgical techniques for the face, head & neck and breast following oncology surgery. An example of the development and refinement of innovative flap procedures is the Deep Inferior Epigastric Perforator Flap (DIEP) breast reconstruction technique, which involves dissection of the skin and fatty tissue in the abdomen to restore the breast mound while maintaining the integrity, function and strength of the donor abdominal site compared to other procedures.
- Tissue EngineeringWhile my clinical research focuses on technical improvements of reconstructive techniques, I am also involved in tissue engineering of adipose tissue and mucosa using living cells in artificial supporting scaffolds to replace missing tissues. This is a technology that uses the patients' own cells in the lab and transplants the engineered living tissue back into the body. We have developed a 3-dimensional tissue engineered mucosa substitute, which we use to study radiation effects. The ultimate goal of this research is to maximize the reconstructive outcomes and quality of life while minimizing the disability caused to the donor tissue sites.
- Functional, Aesthetic and Quality of Life OutcomesI have a strong interest in the functional, aesthetic and quality of life outcomes after reconstructive surgery and have received grant funding for research projects investigating these outcomes. In addition, I am developing prospective, outcomes databases for Breast Restoration as well as Head & Neck Cancer Reconstruction at UHN.
Implications of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) for Breast Cancer Reconstruction: An Update for Surgical Oncologists.
Ann Surg Oncol. 2017 Jul 31;:
Preoperative Computed Tomography Angiogram (CTA) Measurement of Abdominal Muscles is a Valuable Risk Assessment for Bulge Formation after Microsurgical Abdominal Breast Reconstruction.
Plast Reconstr Surg. 2017 Mar 06;:
Predicting Complications in Immediate Alloplastic Breast Reconstruction: How Useful Is the American College of Surgeons National Surgical Quality Improvement Program Surgical Risk Calculator?
Plast Reconstr Surg. 2017 Mar;139(3):532-538
Patient, tumour and treatment factors affect complication rates in soft tissue sarcoma flap reconstruction in a synergistic manner.
Eur J Surg Oncol. 2017 Feb 08;:
Erratum to "Predictors and consequences of intraoperative microvascular problems in autologous breast reconstruction" [J Plast Reconstr Aesthet Surg 69 (2016), 1349-1355].
J Plast Reconstr Aesthet Surg. 2017 Feb;70(2):295
Chronic Postsurgical Pain Outcomes in Breast Reconstruction Patients Receiving Perioperative Transversus Abdominis Plane Catheters at the Donor Site: A Prospective Cohort Follow-up Study.
Pain Pract. 2016 Dec 20;:
Can the ACS-NSQIP surgical risk calculator predict post-operative complications in patients undergoing flap reconstruction following soft tissue sarcoma resection?
J Surg Oncol. 2016 Oct;114(5):570-575
A Comparison of Psychological Response, Body Image, Sexuality, and Quality of Life between Immediate and Delayed Autologous Tissue Breast Reconstruction: A Prospective Long-Term Outcome Study.
Plast Reconstr Surg. 2016 Oct;138(4):772-80
Unfavorable Results After Free Tissue Transfer to Head and Neck: Lessons Based on Experience from the University of Toronto.
Clin Plast Surg. 2016 Oct;43(4):639-51
Can the American College of Surgeons NSQIP surgical risk calculator identify patients at risk of complications following microsurgical breast reconstruction?
J Plast Reconstr Aesthet Surg. 2016 Oct;69(10):1356-62
Cancer Clinical Research Unit (CCRU), Princess Margaret Cancer Centre
Chief, Division of Plastic & Reconstructive Surgery, Department of Surgery and Department of Surgical Oncology, University Health Network
Wharton Chair in Reconstructive Plastic Surgery, Division of Plastic Surgery, University of Toronto
Associate Professor, Surgeon-Investigator, Division of Plastic Surgery, University of Toronto
Associate Member, Institute of Medical Sciences, School of Graduate Studies, University of Toronto