Dr. Hofer obtained his medical degree from the University of Amsterdam in 1992. He then completed his PhD studying tissue oxygen tension as an indicator of tissue perfusion in the Department of Surgical Research, Academic Medical Center, Amsterdam. He obtained his board certification in Plastic Surgery from the Netherlands in 2000 and became the first Plastic Surgeon to be awarded the highly prestigious Dutch Cancer Society clinical fellowship, which funded his one-year Microsurgery Research fellowship at the Bernard O'Brien Institute of Microsurgery at St. Vincent's Hospital and the University of Melbourne in Melbourne, Australia. Dr. Hofer is internationally recognized for his outstanding contributions in the areas of clinical service, education, and research. Prior to becoming the Division's first international candidate to be recruited in over a decade, Dr. Hofer was an Associate Professor in the Department of Plastic and Reconstructive Surgery, Erasmus Medical Center, Rotterdam and the Head of Plastic and Reconstructive Surgical Oncology.
- Innovative Surgical TechniquesMy main clinical research interest is in the development, refinement and evaluation of innovative plastic and reconstructive surgical techniques for the face, head & neck and breast following oncology surgery. An example of the development and refinement of innovative flap procedures is the Deep Inferior Epigastric Perforator Flap (DIEP) breast reconstruction technique, which involves dissection of the skin and fatty tissue in the abdomen to restore the breast mound while maintaining the integrity, function and strength of the donor abdominal site compared to other procedures.
- Tissue EngineeringWhile my clinical research focuses on technical improvements of reconstructive techniques, I am also involved in tissue engineering of adipose tissue and mucosa using living cells in artificial supporting scaffolds to replace missing tissues. This is a technology that uses the patients' own cells in the lab and transplants the engineered living tissue back into the body. We have developed a 3-dimensional tissue engineered mucosa substitute, which we use to study radiation effects. The ultimate goal of this research is to maximize the reconstructive outcomes and quality of life while minimizing the disability caused to the donor tissue sites.
- Functional, Aesthetic and Quality of Life OutcomesI have a strong interest in the functional, aesthetic and quality of life outcomes after reconstructive surgery and have received grant funding for research projects investigating these outcomes. In addition, I am developing prospective, outcomes databases for Breast Restoration as well as Head & Neck Cancer Reconstruction at UHN.
Limited Endothelial Plasticity of Mesenchymal Stem Cells Revealed by Quantitative Phenotypic Comparisons to Representative Endothelial Cell Controls.
Stem Cells Transl Med. 2018 Sep 30;:
Flap choice does not affect complication rates or functional outcomes following extremity soft tissue sarcoma reconstruction.
J Plast Reconstr Aesthet Surg. 2018 Apr 12;:
Dermatol Surg. 2018 Mar 13;:
Aesthetic and functional outcomes of radial forearm flap donor site reconstruction with biosynthetic skin substitutes.
J Plast Reconstr Aesthet Surg. 2018 Feb 13;:
Flap reconstruction does not increase complication rates following surgical resection of extremity soft tissue sarcoma.
Eur J Surg Oncol. 2017 Nov 26;:
Superficial Soft-Tissue Sarcomas Rarely Require Advanced Soft-Tissue Reconstruction following Resection.
Plast Reconstr Surg Glob Open. 2017 Nov;5(11):e1553
Response to "Complications in DIEP Flap Breast Reconstruction after Mastectomy for Breast Cancer: A Prospective Cohort Study Comparing Unilateral and Bilateral Reconstructions".
Ann Surg Oncol. 2017 Nov 16;:
Clin Plast Surg. 2018 Jan;45(1):xiii
Indications and Controversies for Abdominally-Based Complete Autologous Tissue Breast Reconstruction.
Clin Plast Surg. 2018 Jan;45(1):83-91
J Plast Reconstr Aesthet Surg. 2017 Sep 12;:
Cancer Clinical Research Unit (CCRU), Princess Margaret Cancer Centre
Chief, Division of Plastic & Reconstructive Surgery, Department of Surgery and Department of Surgical Oncology, University Health Network
Wharton Chair in Reconstructive Plastic Surgery, Division of Plastic Surgery, University of Toronto
Associate Professor, Surgeon-Investigator, Division of Plastic Surgery, University of Toronto
Associate Member, Institute of Medical Sciences, School of Graduate Studies, University of Toronto