Our research focuses on cell signalling, cancer genetics and molecular oncology mechanisms. We are particularly interested in studying the role of the DNA damage response, NOTCH, WNT and the HIPPO signaling pathways and their role in cancer. Our long-term goal is to contribute to improving diagnosis and therapy for cancer patients.
Nat Commun. 2016;7:12638
The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.
Immunity. 2016 Aug 10;
Oncogene. 2016 Feb 15;
DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration.
Proc Natl Acad Sci U S A. 2014 Oct 27;
Oncogene. 2014 May 26;0
Diabetologia. 2014 Apr;57(4):765-75
Cell Rep. 2013 Dec 26;5(6):1650-63
Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):20982-7
The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival.
J Biol Chem. 2014 Jan 10;289(2):1183-91
J Immunol. 2013 Dec 15;191(12):5840-7
Senior Scientist, Princess Margaret Cancer Centre
Professor, Departments of Medical Biophysics & Immunology, University of Toronto