Razqallah Hakem, PhD

Senior Scientist, Princess Margaret Cancer Centre
Keywords: BRCA1, DNA damage and repair, cancer, cell signalling, tumour suppressors
Our research focuses on cell signalling, cancer genetics and molecular oncology mechanisms. We are particularly interested in studying the role of the DNA damage response, NOTCH, WNT and the HIPPO signaling pathways and their role in cancer. Our long-term goal is to contribute to improving diagnosis and therapy for cancer patients.
Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia.
Leukemia. 2018 Jun 08;:
Barghout SH, Patel PS, Wang X, Xu GW, Kavanagh S, Halgas O, Zarabi SF, Gronda M, Hurren R, Jeyaraju DV, MacLean N, Brennan S, Hyer ML, Berger A, Traore T, Milhollen M, Smith AC, Minden MD, Pai EF, Hakem R, Schimmer AD
RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation.
Nat Commun. 2016;7:12638
Guturi KK, Bohgaki M, Bohgaki T, Srikumar T, Ng D, Kumareswaran R, El Ghamrasni S, Jeon J, Patel P, Eldin MS, Bristow R, Cheung P, Stewart GS, Raught B, Hakem A, Hakem R
The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.
Immunity. 2016 Aug 10;
Alvarez-Diaz S, Dillon CP, Lalaoui N, Tanzer MC, Rodriguez DA, Lin A, Lebois M, Hakem R, Josefsson EC, O'Reilly LA, Silke J, Alexander WS, Green DR, Strasser A
Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation.
Oncogene. 2016 Feb 15;
Ghamrasni SE, Cardoso R, Li L, Guturi KK, Bjerregaard VA, Liu Y, Venkatesan S, Hande MP, Henderson JT, Sanchez O, Hickson ID, Hakem A, Hakem R
DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration.
Proc Natl Acad Sci U S A. 2014 Oct 27;
Kim Y, Tarallo V, Kerur N, Yasuma T, Gelfand BD, Bastos-Carvalho A, Hirano Y, Yasuma R, Mizutani T, Fowler BJ, Li S, Kaneko H, Bogdanovich S, Ambati BK, Hinton DR, Hauswirth WW, Hakem R, Wright C, Ambati J
Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression.
Oncogene. 2014 May 26;0
El Ghamrasni S, Cardoso R, Halaby MJ, Zeegers D, Harding S, Kumareswaran R, Yavorska T, Chami N, Jurisicova A, Sanchez O, Hande MP, Bristow R, Hakem R, Hakem A
The role of caspase-8 in amyloid-induced beta cell death in human and mouse islets.
Diabetologia. 2014 Apr;57(4):765-75
Park YJ, Woo M, Kieffer TJ, Hakem R, Safikhan N, Yang F, Ao Z, Warnock GL, Marzban L
LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction.
Cell Rep. 2013 Dec 26;5(6):1650-63
Li J, Chen X, Ding X, Cheng Y, Zhao B, Lai ZC, Al Hezaimi K, Hakem R, Guan KL, Wang CY
RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.
Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):20982-7
Bohgaki M, Bohgaki T, El Ghamrasni S, Srikumar T, Maire G, Panier S, Fradet-Turcotte A, Stewart GS, Raught B, Hakem A, Hakem R
The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival.
J Biol Chem. 2014 Jan 10;289(2):1183-91
Koenig A, Buskiewicz IA, Fortner KA, Russell JQ, Asaoka T, He YW, Hakem R, Eriksson JE, Budd RC

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Senior Scientist, Princess Margaret Cancer Centre

Professor, Departments of Medical Biophysics & Immunology, University of Toronto