The focus of our research is to characterize novel genetic risk factors, and to unravel mechanisms that regulate cell signaling pathways important for human cancer. In addition, a major effort of our research program is to identify novel strategies that improve cancer therapy.

Currently ongoing projects:
1. BRCA1 and BRCA2 and their role in cancer
2. Role of signaling pathways (e.g. NOTCH, WNT and Hippo) in cancer
3. Crispr screening to identify targets to kill breast, ovarian and other tumor types

Using multidisciplinary approaches and collaborating with scientists, clinicians, pathologists and bioinformatics experts, we focus on our long-term goal “to contribute to better diagnosis and therapy for cancer patients”.

For a list of Dr. Hakem's publications, please visit PubMed, Scopus or ORCID.


Professor, Department of Medical Biophysics, University of Toronto
Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto