Razqallah Hakem

Razqallah Hakem, PhD

Our research focuses on cell signalling, cancer genetics and molecular oncology mechanisms. We are particularly interested in studying the role of the DNA damage response, NOTCH, WNT and the HIPPO signaling pathways and their role in cancer. Our long-term goal is to contribute to improving diagnosis and therapy for cancer patients.
Nat Commun. 2016;7:12638
Guturi KK, Bohgaki M, Bohgaki T, Srikumar T, Ng D, Kumareswaran R, El Ghamrasni S, Jeon J, Patel P, Eldin MS, Bristow R, Cheung P, Stewart GS, Raught B, Hakem A, Hakem R
Immunity. 2016 Aug 10;
Alvarez-Diaz S, Dillon CP, Lalaoui N, Tanzer MC, Rodriguez DA, Lin A, Lebois M, Hakem R, Josefsson EC, O'Reilly LA, Silke J, Alexander WS, Green DR, Strasser A
Oncogene. 2016 Feb 15;
Ghamrasni SE, Cardoso R, Li L, Guturi KK, Bjerregaard VA, Liu Y, Venkatesan S, Hande MP, Henderson JT, Sanchez O, Hickson ID, Hakem A, Hakem R
Proc Natl Acad Sci U S A. 2014 Oct 27;
Kim Y, Tarallo V, Kerur N, Yasuma T, Gelfand BD, Bastos-Carvalho A, Hirano Y, Yasuma R, Mizutani T, Fowler BJ, Li S, Kaneko H, Bogdanovich S, Ambati BK, Hinton DR, Hauswirth WW, Hakem R, Wright C, Ambati J
Oncogene. 2014 May 26;0
El Ghamrasni S, Cardoso R, Halaby MJ, Zeegers D, Harding S, Kumareswaran R, Yavorska T, Chami N, Jurisicova A, Sanchez O, Hande MP, Bristow R, Hakem R, Hakem A
Diabetologia. 2014 Apr;57(4):765-75
Park YJ, Woo M, Kieffer TJ, Hakem R, Safikhan N, Yang F, Ao Z, Warnock GL, Marzban L
Cell Rep. 2013 Dec 26;5(6):1650-63
Li J, Chen X, Ding X, Cheng Y, Zhao B, Lai ZC, Al Hezaimi K, Hakem R, Guan KL, Wang CY
Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):20982-7
Bohgaki M, Bohgaki T, El Ghamrasni S, Srikumar T, Maire G, Panier S, Fradet-Turcotte A, Stewart GS, Raught B, Hakem A, Hakem R
J Biol Chem. 2014 Jan 10;289(2):1183-91
Koenig A, Buskiewicz IA, Fortner KA, Russell JQ, Asaoka T, He YW, Hakem R, Eriksson JE, Budd RC
J Immunol. 2013 Dec 15;191(12):5840-7
Boulianne B, Rojas OL, Haddad D, Zaheen A, Kapelnikov A, Nguyen T, Li C, Hakem R, Gommerman JL, Martin A

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Professor, Departments of Medical Biophysics & Immunology, University of Toronto