Paul Sandor

Paul Sandor, BSc, MD, FRCPC

My research is focused on neurobiology, clinical pharmacology and behavioral treatments of Tourette syndrome (TS) and related neurodevelopmental disorders.

Imaging
We have developed a novel paradigm to visualize brain activation associated with premonitory urge in patients with TS. This method appears to distinguish between those affected by TS and unaffected controls. If confirmed, this would represent the first biological marker for TS.

Psychopharmacology
Currently, we study the effects of clonidine on sleep and aggressive behavior in children with TS. We are also developing pharmacogenetic studies in a TS population.

We are examining the behavioural and imaging correlates of cannabis treatment in patients with treatment resistant TS.

Genetics
With Dr. Cathy Barr, we are members of the International Genetics of Tourette's Syndrome Consortium sponsored by the U.S. Tourette Syndrome Association. We have collected detailed clinical information about nine medium-large pedigrees with three generations affected. We are now pursuing nuclear family sib-pair and trio strategy seeking genes that predispose certain people to TS. To date our group has studied over 600 individuals as our contribution to this effort. Recently we have reported a genetic linkage in a large TS pedigree: Chromosome 5 and Gilles de la Tourette syndrome: Linkage in a large pedigree and association study of six candidates in the region. Laurin N, Wigg KG, Feng Y, Sandor P, Barr CL. Am J Med Genet B Neuropsychiatr Genet. 2009 Jan 5;150B(1):95-103.
Neuron. 2017 May 03;94(3):486-499.e9
Willsey AJ, Fernandez TV, Yu D, King RA, Dietrich A, Xing J, Sanders SJ, Mandell JD, Huang AY, Richer P, Smith L, Dong S, Samocha KE, Tourette International Collaborative Genetics (TIC Genetics), Tourette Syndrome Association International Consortium...
J Psychiatry Neurosci. 2017 Sep;42(5):300-306
Bhikram T, Abi-Jaoude E, Sandor P
Nature. 2016 08 18;536(7616):285-91
Lek M, Karczewski KJ, Minikel EV, Samocha KE, Banks E, Fennell T, O'Donnell-Luria AH, Ware JS, Hill AJ, Cummings BB, Tukiainen T, Birnbaum DP, Kosmicki JA, Duncan LE, Estrada K, Zhao F, Zou J, Pierce-Hoffman E, Berghout J, Cooper DN, Deflaux N,...
Eur Child Adolesc Psychiatry. 2017 Nov 02;:
Greenberg E, Tung ES, Gauvin C, Osiecki L, Yang KG, Curley E, Essa A, Illmann C, Sandor P, Dion Y, Lyon GJ, King RA, Darrow S, Hirschtritt ME, Budman CL, Grados M, Pauls DL, Keuthen NJ, Mathews CA, Scharf JM, Tourette Association of America...
Psychol Med. 2017 Jun 27;:1-15
Hirschtritt ME, Darrow SM, Illmann C, Osiecki L, Grados M, Sandor P, Dion Y, King RA, Pauls D, Budman CL, Cath DC, Greenberg E, Lyon GJ, Yu D, McGrath LM, McMahon WM, Lee PC, Delucchi KL, Scharf JM, Mathews CA
J Am Acad Child Adolesc Psychiatry. 2017 Jul;56(7):610-617.e1
Darrow SM, Grados M, Sandor P, Hirschtritt ME, Illmann C, Osiecki L, Dion Y, King R, Pauls D, Budman CL, Cath DC, Greenberg E, Lyon GJ, McMahon WM, Lee PC, Delucchi KL, Scharf JM, Mathews CA
Neuron. 2017 Jun 21;94(6):1101-1111.e7
Huang AY, Yu D, Davis LK, Sul JH, Tsetsos F, Ramensky V, Zelaya I, Ramos EM, Osiecki L, Chen JA, McGrath LM, Illmann C, Sandor P, Barr CL, Grados M, Singer HS, Nöthen MM, Hebebrand J, King RA, Dion Y, Rouleau G, Budman CL, Depienne C, Worbe Y, Hartmann...
J Neuropsychiatry Clin Neurosci. 2017 May 03;:appineuropsych16110310
Abi-Jaoude E, Chen L, Cheung P, Bhikram T, Sandor P
Am J Psychiatry. 2016 Nov 4;:appiajp201616020240
Darrow SM, Hirschtritt ME, Davis LK, Illmann C, Osiecki L, Grados M, Sandor P, Dion Y, King R, Pauls D, Budman CL, Cath DC, Greenberg E, Lyon GJ, Yu D, McGrath LM, McMahon WM, Lee PC, Delucchi KL, Scharf JM, Mathews CA, Tourette Syndrome Association...
Front Neurosci. 2016;10:428
Alexander J, Potamianou H, Xing J, Deng L, Karagiannidis I, Tsetsos F, Drineas P, Tarnok Z, Rizzo R, Wolanczyk T, Farkas L, Nagy P, Szymanska U, Androutsos C, Tsironi V, Koumoula A, Barta C, TSGeneSEE, Sandor P, Barr CL, Tischfield J, Paschou P, Heiman...

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Professor, Department of Psychiatry, University of Toronto