Johane P Allard

Johane P Allard, MD, FRCPC

Dr. Allard and her staff are experienced in the assessment of nutritional status (assessment of dietary intake, malnutrition, anthropometry) and laboratory measurements related to oxidative stress (plasma vitamin levels, antioxidant potential, lipid peroxidation). Dr. Allard's successful and long-standing collaborations with numerous researchers at UHN, University of Toronto, University of Guelph, Western Ontario University and other institutions across Canada allow her and her team to apply cutting-edge technologies (e.g., microarrays for gene expression, mass spectrometry for lipidomic profiling, Illumina technology and polymerase chain-reaction for intestinal microbiota). Furthermore, Dr. Allard's cooperation with the UHN Transplant Program allows for the inclusion of healthy living liver donors as healthy controls for liver studies.

Dr. Allard's areas of expertise also include inflammatory bowel disease, celiac disease, and short bowel syndrome. In addition, she and her team have conducted studies on patients with HIV infection or chronic Hepatitis C infection, as well as lung- and liver transplant patients.

More information on Dr. Allard's clinical trials can be found in her publications and in the clinical trials registry ClinicalTrials.gov.
  • Non-alcoholic fatty liver disease
    The current focus of Dr. Allard's research is non-alcoholic fatty liver disease (NAFLD). She is interested in a number of nutrition-related factors that could play a role in the development and progression of NAFLD, including:
    • Diet and lifestyle (dietary intake, obesity, physical activity)
    • Bariatric surgery
    • Oxidative stress and antioxidants
    • Lipid profile of liver and other tissues (lipid classes, fatty acid composition)
    • Hepatic gene expression (genes related to oxidative stress, lipid metabolism, insulin resistance)
    • Intestinal microbiota
  • Parenteral nutrition
    Dr. Allard's team is managing the Canadian Home Total Parenteral Nutrition (TPN) Registry, which collects demographic information, medical history and health status of patients in Home TPN programs across Canada. Currently, 7 centers are participating (Alberta Health Services, Edmonton; Alberta Health Services, Calgary; BC Home Parenteral Nutrition Program, Vancouver; Hamilton Health Sciences HPN Program; St. Boniface Hospital, Winnipeg; St. Michael's Hospital, Toronto; University Health Network, Toronto). Data are continuously collected in 2 year follow up intervals and entered into the database through a web interface. Data are analyzed to standardize practice and improve quality of care. As of September 2014, more than 460 patients have been enrolled (currently funded by Baxter Corp., Royal Drugs Ltd., and Calea Inc.). Based on the Home TPN registry, a multicenter randomized controlled trial has been developed to examine the effects of a fish- oil based lipid emulsion on parenteral nutrition-associated liver disease in this population.

    Dr. Allard's team has also recently created a UHN registry for inpatients receiving parenteral nutrition, and is conducting a study comparing the effects of two different lipid emulsions on clinical outcomes in surgical or medical inpatients receiving TPN.
  • Nutrition Care in Canadian Hospitals
    Dr. Allard is one of the co-chairs of the recently founded Canadian Malnutrition Task Force. The aim of the task force is to create a knowledge base and close the gaps between research and practice in the prevention, detection and treatment of malnutrition in Canadians through the continuum of care. Their first studies "Nutrition Care in Canadian Hospitals" and the validation of a malnutrition screening tool were recently conducted at multiple hospitals across Canada, including the University Health Network with Dr. Allard as a site investigator. Results will be presented on the Task Force website (www.nutritioncareincanada.ca).
Sci Rep. 2017 Aug 31;7(1):10277
Bhat M, Pasini E, Copeland J, Angeli M, Husain S, Kumar D, Renner E, Teterina A, Allard J, Guttman DS, Humar A
J Hum Nutr Diet. 2017 May 19;:
Keller H, Payette H, Laporte M, Bernier P, Allard J, Duerksen D, Gramlich L, Jeejeebhoy K
Nutrients. 2017 May 06;9(5):
Bielawska B, Allard JP
Transplant Direct. 2017 Feb;3(2):e127
Allard J, Durand C, Anthony SJ, Dumez V, Hartell D, Hébert MJ, West LJ, Wright L, Fortin MC
Eur J Clin Nutr. 2017 Feb 22;:
Keller H, Laporte M, Payette H, Allard J, Bernier P, Duerksen D, Gramlich L, Jeejeebhoy K
Clin Nutr. 2016 Sep 19;:
Curtis LJ, Bernier P, Jeejeebhoy K, Allard J, Duerksen D, Gramlich L, Laporte M, Keller HH
World J Hepatol. 2016 Sep 28;8(27):1128-1136
Bhat M, Arendt BM, Bhat V, Renner EL, Humar A, Allard JP
J Hum Nutr Diet. 2015 Dec;28(6):546-57
Keller H, Allard J, Vesnaver E, Laporte M, Gramlich L, Bernier P, Davidson B, Duerksen D, Jeejeebhoy K, Payette H
Nutr Diabetes. 2016;6(7):e220
Ma DW, Arendt BM, Hillyer LM, Fung SK, McGilvray I, Guindi M, Allard JP

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Professor of Medicine, University of Toronto
Division Director, Department of Gastroenterology, University of Toronto
Division Head, Gastroenterology, Sunnybrook Health Sciences Centre